17 active not recruiting. 17 Phase 3, 3 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 17 | Active not recruiting 17 |
| Phase 2 | 3 | Active not recruiting 3 |
Follow Precursor Cell Lymphoblastic Leukemia-Lymphoma: new trials by email Literature Review of Precursor Cell Lymphoblastic Leukemia-Lymphoma trials Research Report on Precursor Cell Lymphoblastic Leukemia-Lymphoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| PD-1 Inhibitors +Venetoclax+CAG Regimens in R/R T-ALL PD-1 Inhibitors - Acute T Lymphoblastic Leukemia (T-ALL) | Phase 3 | Active not recruiting | Fujian Medical University Union Hospital | 40 | 2025-05-01 | 2026-04-21 |
| Preventing of GVHD With Post-transplantation Cyclophosphamide, Abatacept, Vedolizumab and Baricitinib at Children and Young Adults With Hemoblastosis Baricitinib - Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia | Phase 2 / Phase 3 | Active not recruiting | Federal Research Institute of Pediatric Hematology, Oncology and Immunology | 150 | 2023-12-01 | 2024-08-23 |
| Studying the Effect of Levocarnitine in Protecting the Liver From Chemotherapy for Leukemia or Lymphoma Biospecimen Collection, Calaspargase Pegol, Levocarnitine - B Acute Lymphoblastic Leukemia, B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1 | Phase 3 | Active not recruiting | Children's Oncology Group | 440 | 2023-08-24 | 2026-08-21 |
| Mismatched Related Donor Versus Matched Unrelated Donor Stem Cell Transplantation for Children, Adolescents, and Young Adults With Acute Leukemia or Myelodysplastic Syndrome Biospecimen Collection, Bone Marrow Aspiration, Busulfan - Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia | Phase 3 | Active not recruiting | Children's Oncology Group | 66 | 2023-03-15 | 2026-07-30 |
| Preventing of GVHD With Post-transplantation Cyclophosphamide, Abatacept, Vedolizumab and Calcineurin Inhibitor at Patients With Hemoblastosis GVHD prevention: post-transplantation cyclophosphamide, abatacept, vedolizumab, calcineurin inhibitor - Acute Lymphoblastic Leukemia, Myeloblastic Leukemia | Phase 3 | Active not recruiting | Federal Research Institute of Pediatric Hematology, Oncology and Immunology | 56 | 2022-08-23 | 2023-09-28 |
| Precision-T: A Randomized Study of Orca-T in Recipients Undergoing Allogeneic Transplantation for Hematologic Malignancies Orca-T, Standard-of-Care - Acute Myeloid Leukemia, Acute Lymphoid Leukemia | Phase 3 | Active not recruiting | Orca Biosystems, Inc. | 187 | 2022-06-21 | 2026-03-04 |
| Investigation of Remimazolam in Children Undergoing Sedation for Medical Procedures Remimazolam - Pediatric ALL | Phase 2 / Phase 3 | Active not recruiting | Acacia Pharma Ltd | 100 | 2021-11-15 | 2025-07-01 |
| Sequential Treatment With Ponatinib and Blinatumomab vs Chemotherapy and Imatinib in Newly Diagnosed Adult Ph+ ALL Ponatinib + Blinatumomab, Chemotherapy + Imatinib - Acute Lymphoblastic Leukemia (Philadelphia Chromosome Positive), ALL, Adult | Phase 3 | Active not recruiting | Gruppo Italiano Malattie EMatologiche dell'Adulto | 236 | 2021-09-08 | 2025-01-23 |
| An Extension Study of Venetoclax for Subjects Who Have Completed a Prior Venetoclax Clinical Trial Venetoclax - Chronic Lymphocytic Leukemia, Acute Myeloid Leukemia | Phase 3 | Active not recruiting | AbbVie | 165 | 2019-09-06 | 2026-05-13 |
| A Study to Investigate Blinatumomab in Combination With Chemotherapy in Patients With Newly Diagnosed B-Lymphoblastic Leukemia Asparaginase Erwinia chrysanthemi, Blinatumomab, Cyclophosphamide - B Acute Lymphoblastic Leukemia, B Lymphoblastic Lymphoma | Phase 3 | Active not recruiting | National Cancer Institute (NCI) | 6720 | 2019-07-03 | 2026-11-02 |
| Imatinib Mesylate and Combination Chemotherapy in Treating Patients With Newly Diagnosed Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia Allogeneic Hematopoietic Stem Cell Transplantation, Calaspargase Pegol, Cyclophosphamide - Acute Lymphoblastic Leukemia, B Acute Lymphoblastic Leukemia | Phase 3 | Active not recruiting | Children's Oncology Group | 352 | 2017-08-08 | 2026-10-05 |
| Total Therapy XVII for Newly Diagnosed Patients With Acute Lymphoblastic Leukemia and Lymphoma Prednisone, Vincristine, Daunorubicin - Acute Lymphoblastic Leukemia, Acute Lymphoblastic Lymphoma | Phase 2 / Phase 3 | Active not recruiting | St. Jude Children's Research Hospital | 790 | 2017-03-29 | 2026-06-17 |
| Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Children and Adolescents Pegaspargase, Erwinia asparaginase, Cyclophosphamide - Acute Lymphoblastic Leukemia, Pediatric | Phase 3 | Active not recruiting | Dana-Farber Cancer Institute | 560 | 2017-03-03 | 2026-07-16 |
| A French Protocol for the Treatment of Acute Lymphoblastic Leukemia (ALL) in Children and Adolescents pegaspargase 1250 IU/m2 x 2, pegaspargase 2500 IU/m2 x 1 - Acute Lymphoblastic Leukemia | Phase 3 | Active not recruiting | Assistance Publique - Hôpitaux de Paris | 2044 | 2016-09-19 | 2025-09-16 |
| LBL-2016 for Children or Adolescents in China Prednisone,Vincristine, Pegylated-asparaginase, Cytarabine, Cyclophosphamide, Daunorubicin, 6-mercaptopurine, 6-mercaptopurine,Methotrexate, Dexamethasone,Vincristine, Pegylated-asparaginase, Cytarabine, Cyclophosphamide, Doxorubicin, 6-mercaptopurine - Lymphoblastic Lymphoma | Phase 3 | Active not recruiting | Children's Cancer Group, China | 150 | 2016-01-01 | 2026-03-18 |
| Combination Chemotherapy With or Without Bortezomib in Treating Younger Patients With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia or Stage II-IV T-Cell Lymphoblastic Lymphoma Bortezomib, Cyclophosphamide, Cytarabine - Adult T Acute Lymphoblastic Leukemia, Ann Arbor Stage II Adult Lymphoblastic Lymphoma | Phase 3 | Active not recruiting | National Cancer Institute (NCI) | 847 | 2014-10-04 | 2026-10-21 |
| Combination Chemotherapy With or Without Blinatumomab in Treating Patients With Newly Diagnosed BCR-ABL-Negative B Lineage Acute Lymphoblastic Leukemia Allogeneic Hematopoietic Stem Cell Transplantation, Biospecimen Collection, Blinatumomab - Acute Lymphoblastic Leukemia, B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative | Phase 3 | Active not recruiting | National Cancer Institute (NCI) | 488 | 2014-05-19 | 2026-09-21 |
Leukemia, Biphenotypic, Acute (6) · Burkitt Lymphoma (4) · Leukemia, Myeloid, Acute (4) · Myelodysplastic Syndromes (4) · Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (4) · Lymphoma (3) · Down Syndrome (1) · Graft vs Host Disease (1) · Leukemia (1) · Leukemia, Lymphocytic, Chronic, B-Cell (1) · Leukemia, Myelomonocytic, Acute (1) · Leukemia, Myelomonocytic, Juvenile (1) · Lymphoma, Non-Hodgkin (1) · Multiple Myeloma (1)
Hematologic Diseases (17) · Hemic and Lymphatic Diseases (17) · Immune System Diseases (17) · Immunoproliferative Disorders (17) · Leukemia, Lymphoid (17) · Lymphatic Diseases (17) · Lymphoproliferative Disorders (17) · Neoplasms by Histologic Type (17) · Leukemia (16) · Neoplasms (16) · Leukemia, Myeloid (5) · Lymphoma (5) · Bone Marrow Diseases (4) · DNA Virus Infections (4) · Epstein-Barr Virus Infections (4)
Cyclophosphamide (9) · pegaspargase (9) · Cytarabine (8) · Methotrexate (8) · Dexamethasone (7) · Mercaptopurine (7) · Vincristine (7) · Calcium Dobesilate (6) · Doxorubicin (6) · Etoposide (6) · Asparaginase (5) · Daunorubicin (5) · Leucovorin (5) · merphos (5) · Prednisone (4)
Children's Oncology Group (3) · National Cancer Institute (NCI) (3) · Federal Research Institute of Pediatric Hematology, Oncology and Immunology (2) · AbbVie (1) · Acacia Pharma Ltd (1) · Assistance Publique - Hôpitaux de Paris (1) · Children's Cancer Group, China (1) · Dana-Farber Cancer Institute (1) · Fujian Medical University Union Hospital (1) · Gruppo Italiano Malattie EMatologiche dell'Adulto (1) · Orca Biosystems, Inc. (1) · St. Jude Children's Research Hospital (1)
United States (11) · Canada (8) · Australia (6) · New Zealand (4) · France (3) · Puerto Rico (3) · Russia (3) · Austria (2) · Belgium (2) · China (2) · Denmark (2) · Hong Kong (2) · Israel (2) · Italy (2) · Sweden (2)
Andrea Biondi (1) · David T Teachey (1) · Etan Orgel (1) · Heather J Symons (1) · Hiroto Inaba, MD, PhD (1) · Lewis B Silverman (1) · Mark R Litzow (1) · Melissa Burns, MD (1) · Shaoyuan Wang, Pro (1) · Sumit Gupta (1) · Yi-Jin Gao, M.D. (1)
PMID 10627444, PMID 16421426, PMID 17003366, PMID 19433688, PMID 23389497, PMID 24344215, PMID 26887549, PMID 32589970, PMID 33844429, PMID 34933343, PMID 35271306, PMID 35478711, PMID 36603187, PMID 38457359, PMID 39047240, PMID 39651791, PMID 40905823, PMID 41385341, PMID 41469545, PMID 42154791, PMID 42806776, PMID 42832396, PMID 42874102
U10CA180886 (4), 2017 (1), U10CA021115 (1), U10CA098543 (1), U10CA180820 (1), U24CA196172 (1), U24CA196173 (1), UG1CA189955 (1)