15 completed, 5 recruiting, 5 unknown, 3 not yet recruiting. 13 Not applicable, 6 Phase 1, 6 Phase 2, 1 Phase 3.
Follow Nut Hypersensitivity: new trials by email Literature Review of Nut Hypersensitivity trials Research Report on Nut Hypersensitivity
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| UNC Cashew Sublingual Immunotherapy Cashew sublingual immunotherapy, Placebo sublingual immunotherapy - Cashew Nut Allergy, Tree Nut Allergies | Phase 2 | Not yet recruiting | University of North Carolina, Chapel Hill | 45 | 2027-03-01 | 2026-10-20 |
| A Randomized Controlled Trial of Oral Immunotherapy Versus Allergen Avoidance in Children Under 2 Years With Food Allergy Oral immunotheraphy (OIT) - Food Allergy in Children, Oral Immunotherapy for Food Allergy | Not applicable | Not yet recruiting | Copenhagen Studies on Asthma in Childhood | 120 | 2026-09-01 | 2026-09-17 |
| Multi-Food Oral Immunotherapy for Peanut and Tree Nuts Multi-Food Oral Immunotherapy (Multi-OIT) with Peanut and Tree Nuts Proteins, Standard of Care (Elimination Diet) - Food Allergies, Food Allergy in Children | Not applicable | Not yet recruiting | Medical University of Warsaw | 39 | 2026-09-01 | 2026-08-13 |
| A Phase 1 Study of Cizutamig in IgE Mediated Diseases Cizutamig - IgE-Mediated Hypersensitivity, IgE Mediated Food Allergy | Phase 1 | Withdrawn | Candid Therapeutics | 2026-04-01 | 2026-07-22 | |
| The NACHO Trial (Nut Allergy Children OIT) Cashew nut oral immunotherapy - Oral Immunotherapy for Food Allergy, Tree Nut Allergy | Not applicable | Recruiting | HUS Skin and Allergy Hospital | 45 | 2024-09-13 | 2025-04-16 |
| Thresholds In Food Allergy evaluaTion And predictioN Oral food challenge - Tree Nut Allergy, Food Allergy | Recruiting | Hamilton Health Sciences Corporation | 2000 | 2023-11-01 | 2024-06-03 | |
| Understanding the Immune System's Role in Tree Nut and Peanut Allergies: Key Biomarkers for Diagnosis and Treatment Monitoring and Treatment Targets Food Allergy, Food Allergy in Children | Active not recruiting | Luxembourg Institute of Health | 90 | 2023-10-02 | 2025-12-02 | |
| TRADE Trial - Tree Nut Immunotherapy Route Development and Evaluation Food - Tree Nut Allergy, Food Allergy | Not applicable | Recruiting | Hamilton Health Sciences Corporation | 60 | 2023-09-01 | 2024-06-03 |
| Efficacy and Safety of Oral Cashew Nut Immunotherapy in Children (CAJESITO) No intervention - Allergy;Food, Allergy, Nut | Unknown | Central Hospital, Nancy, France | 40 | 2023-05-10 | 2023-04-24 | |
| Development of Peanut, Sesame, and Tree Nut Allergy in Polish Children at High Risk of Food Allergy Assessment of peanut, tree nuts and sesame allergy - Atopic Dermatitis, Food Allergy | Unknown | Medical University of Warsaw | 240 | 2023-04-17 | 2023-04-19 | |
| The Clinical Impact of the Basophil Activation Test to Diagnose Food Allergy Basophil activation test (BAT), Oral food challenge (OFC) - Food Allergy, Food Allergy in Infants | Not applicable | Unknown | King's College London | 398 | 2023-01-13 | 2023-09-06 |
| Immune-supportive Diet and Gut Permeability in Allergic Children Immune-supportive diet, Standard care - Peanut Allergy, Nut Allergy | Not applicable | Recruiting | Onze Lieve Vrouwe Gasthuis | 132 | 2022-09-08 | 2025-05-01 |
| Open-label Extension Study of ADP101 ADP101 - Food Allergy | Phase 1 / Phase 2 | Terminated | Alladapt Immunotherapeutics, Inc. | 45 | 2022-03-14 | 2024-03-26 |
| Preventing Anaphylaxis With Acalabrutinib Acalabrutinib - Food Allergy, Food Allergy Peanut | Phase 2 | Completed | Johns Hopkins University | 10 | 2021-12-16 | 2023-09-28 |
| Low Dose Multi-Nut Oral Immunotherapy in Pre-schoolers With a Multi-Nut Allergy Multi-nut OIT - Allergy, Nut | Not applicable | Completed | Murdoch Childrens Research Institute | 12 | 2021-11-16 | 2026-02-06 |
| Accidental Reactions in Peanut/Tree Nut Allergic Children Peanut and Tree Nut Allergy | Completed | University Hospital, Lille | 147 | 2021-09-22 | 2025-12-26 | |
| The TreEat Study- Can Early Introduction of Tree Nuts Prevent Tree Nut Allergy in Infants With Peanut Allergy Home introduction, Multi Nut oral food challenge - Food Allergy in Infants, Nut Allergy | Phase 3 | Completed | Murdoch Childrens Research Institute | 212 | 2021-06-01 | 2026-02-19 |
| ADP101 for Oral Immunotherapy in Food-Allergic Children and Adults Low dose ADP101, High dose ADP101, Pooled Placebo - Food Allergy | Phase 1 / Phase 2 | Completed | Alladapt Immunotherapeutics, Inc. | 73 | 2021-04-20 | 2024-05-16 |
| Efficiency And Tolerance Of Hazelnut Oral Immunotherapy Protocol In Hazelnut Allergic Children Clinical and biological characteristics - Allergy, Nut, Pediatric ALL | Completed | Hospices Civils de Lyon | 70 | 2021-03-01 | 2021-09-17 | |
| Re-Introducing Nuts in Allergic Patients Procedure A, Procedure B, Control group - Tree Nut Allergy | Unknown | National and Kapodistrian University of Athens | 60 | 2019-07-16 | 2024-04-02 |
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Food Hypersensitivity (21) · Peanut Hypersensitivity (16) · Egg Hypersensitivity (7) · Milk Hypersensitivity (7) · Hypersensitivity (5) · Anaphylaxis (3) · Disease (3) · Hypersensitivity, Immediate (3) · Wheat Hypersensitivity (3) · Dermatitis, Atopic (2) · Immune System Diseases (2) · Shellfish Hypersensitivity (2) · Anxiety Disorders (1) · Asthma (1)
Nut and Peanut Hypersensitivity (32) · Immune System Diseases (31) · Hypersensitivity, Immediate (30) · Hypersensitivity (28) · Food Hypersensitivity (12) · Pathologic Processes (3) · Pathological Conditions, Signs and Symptoms (3) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (2) · Dermatitis (2) · Genetic Diseases, Inborn (2) · Skin Diseases (2) · Skin Diseases, Eczematous (2) · Skin Diseases, Genetic (2) · Skin and Connective Tissue Diseases (2) · Bronchial Diseases (1)
Basophil Degranulation Test (2) · Standard of Care (2) · Control Groups (1) · Dietary Supplements (1) · Educational Status (1) · Egg Proteins (1) · Elimination Diets (1) · Food (1) · Immunotherapy (1) · Milk (1) · Patch Tests (1) · acalabrutinib (1)
Alladapt Immunotherapeutics, Inc. (2) · Hamilton Health Sciences Corporation (2) · Helsinki University Central Hospital (2) · King's College London (2) · Lille Catholic University (2) · Medical University of Warsaw (2) · Murdoch Childrens Research Institute (2) · University of North Carolina, Chapel Hill (2) · Bayside Health (1) · Beth Israel Deaconess Medical Center (1) · Candid Therapeutics (1) · Central Hospital, Nancy, France (1) · Copenhagen Studies on Asthma in Childhood (1) · HUS Skin and Allergy Hospital (1) · Hospices Civils de Lyon (1)
United States (8) · Australia (4) · Canada (3) · Finland (3) · France (2) · Poland (2) · United Kingdom (2) · Denmark (1) · Greece (1) · Luxembourg (1) · Netherlands (1) · Switzerland (1)
Derek Chu, MD PhD FRCPC (2) · Mei-Lun Wang, MD (2) · Alexandra Santos, MD PhD (1) · Alexandra Santos, MD, PhD (1) · Annette Kuehn (1) · Christine Sauvage, MD (1) · Creina S Stockley, PhD (1) · Edwin H Kim, MD (1) · Edwin Kim, MD (1) · Jennifer M Rolland, PhD (1) · Kirsten Perrett, MBBS FRACP (1) · Kirsten Perrett, MD. PhD (1) · Marek Kulus, MD, Prof. (1)
PMID 27916627, PMID 31437325, PMID 33217410, PMID 35007745, PMID 35150723, PMID 35386644, PMID 36974653, PMID 37384412, PMID 37973545, PMID 38157981, PMID 40808324
UL1TR001082 (1)