1353 completed, 473 terminated, 375 recruiting, 237 active not recruiting. 2838 Phase 1, 960 Phase 2.
Follow Neuroectodermal Tumors: new trials by email Literature Review of Neuroectodermal Tumors trials Research Report on Neuroectodermal Tumors
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Phase 1/2 Study Evaluating the Safety, PK/PD, and Clinical Activity of Oral JBI-778 in Patients With Brain Metastases, Leptomeningeal Disease, or Recurrent High Grade Glioma JBI-778 - Brain Metastases From Solid Tumors, Leptomeningeal Disease | Phase 1 / Phase 2 | Not yet recruiting | Jubilant Therapeutics Inc. | 113 | 2028-04-01 | 2026-08-07 |
| GD2IL18CART Combined With Bevacizumab for Relapsed and Refractory GD2-positive Solid Tumors Chimeric Antigen Receptor (CAR) Therapy Infusion, Bevacizumab (Avastin) - Neuroblastoma (NBL), Ewing Sarcoma | Phase 1 | Not yet recruiting | Universität Münster | 30 | 2027-10-01 | 2026-11-03 |
| Combination Immunotherapy Targeting Melanoma Antigen-specific CAR T, CTL and DCvac to treat melanoma. - Melanoma | Phase 1 / Phase 2 | Not yet recruiting | Shenzhen Geno-Immune Medical Institute | 30 | 2027-06-30 | 2026-10-30 |
| H3K27M-specific Immune Effector Cells Targeting DMG/DIPG H3K27M-EIEs - Diffuse Midline Glioma or Diffuse Intrinsic Pontine Glioma | Phase 1 / Phase 2 | Not yet recruiting | Shenzhen Geno-Immune Medical Institute | 30 | 2027-06-30 | 2026-10-30 |
| Testing the Addition of Iberdomide to Therapy in People With Neuroblastoma That Has Come Back, Not Responded to Treatment, or Gotten Worse Bone Marrow Aspiration, Bone Marrow Biopsy, Computed Tomography - Recurrent Ganglioneuroblastoma, Recurrent Neuroblastoma | Phase 1 / Phase 2 | Recruiting | National Cancer Institute (NCI) | 76 | 2027-06-25 | 2026-11-06 |
| Metronomic Temozolomide With Dexbrompheniramine for Recurrent High-Grade Glioma/Glioblastoma Dexbrompheniramine, Temozolomide - High Grade Glioma, Glioblastoma | Phase 1 / Phase 2 | Not yet recruiting | University of Nebraska | 41 | 2027-06-01 | 2026-10-05 |
| DLL3 CAR-T Therapy Targeting Brain Tumors 4SCAR DLL3 T cells - Glioblastoma of Cerebellum | Phase 1 / Phase 2 | Not yet recruiting | Shenzhen Geno-Immune Medical Institute | 30 | 2027-06-01 | 2026-11-02 |
| Combination ADI-PEG 20, TMZ, and RT for Treatment of Newly Diagnosed High-grade Glioma (HGG) ADI-PEG 20 (Arginine deiminase pegylated), Temozolomide (TMZ), Standard of Care Radiation Therapy (RT) - Glioblastoma, High-Grade Glioma (WHO III-IV) | Phase 1 / Phase 2 | Not yet recruiting | Sabine Mueller, MD, PhD | 97 | 2027-06-01 | 2026-11-09 |
| FPS-ZM1 With or Without Dexamethasone for Controlling Post Operative Cerebral Edema in Patients With Glioblastoma Biospecimen Collection, Computed Tomography, Dexamethasone - Glioblastoma, Malignant Glioma | Phase 1 | Not yet recruiting | City of Hope Medical Center | 24 | 2027-02-17 | 2026-08-27 |
| Locoregional Administration of TIL and Lymphodepletion in Patients With Melanoma and Liver Metastases Autologous Tumor Infiltrating Lymphocytes, Melphalan, Interleukin-2 - Uveal Melanoma, Metastatic Cutaneous Melanoma | Phase 1 | Not yet recruiting | Vastra Gotaland Region | 6 | 2027-01-31 | 2026-09-09 |
| NG101m Adjuvant Therapy in Glioblastoma Patients Intensity-modulated radiation therapy, Temozolomide, NG101m - Glioblastoma Multiforme | Phase 1 / Phase 2 | Not yet recruiting | NeuGATE Theranostics | 52 | 2027-01-01 | 2025-10-21 |
| A Multicenter Safety and Immunogenicity Window-of-opportunity Phase 1 Interventional Trial Assessing the Combination of IDH1 Vaccine (IDH1-vac) and Vorasidenib in Adult Patients With Recurrent IDH1R132H-mutant Astrocytoma, Grade 2 - 4 (iVOCAL) IDH1R132H-vac, Vorasidenib 40 mg Oral Tablet, Aldara - Imiquimod 5% - Recurrent IDH1R132H-mutant Astrocytoma, Grade 2 - 4 | Phase 1 | Not yet recruiting | Heidelberg University | 45 | 2027-01-01 | 2026-10-16 |
| Locoregional or Systemic Administration of Autologous Tumor Infiltrating Lymphocytes in Patients With Metastatic Melanoma Autologous Tumor Infiltrating Lymphocytes (TIL), Melphalan, Interleukin-2 - Metastatic Uveal Melanoma, Metastatic Cutaneous Melanoma | Phase 1 | Not yet recruiting | Vastra Gotaland Region | 18 | 2027-01-01 | 2026-09-09 |
| CM93 Treatment in Subjects With Epidermal Growth Factor Receptor (EGFR)-Modified Recurrent Glioblastoma (rGBM) CM93 - Glioblastoma | Phase 1 | Not yet recruiting | Crimson Biopharm Inc. | 72 | 2027-01-01 | 2024-08-21 |
| Study of ACC-1898 in Adult Participants With Advanced Solid Tumors ACC-1898 - Hepatocellular Carcinoma, Renal Cell Carcinoma | Phase 1 | Not yet recruiting | AccSalus Biosciences, Inc. | 40 | 2027-01-01 | 2026-10-28 |
| IL-8 Receptor-modified CD70 CAR T Cell Therapy in CD70+ Newly Diagnosed and Recurrent Pediatric High-grade Glioma (pHGG) and Newly Diagnosed Diffuse Intrinsic Pontine Glioma (ndDIPG) Ex-Vivo expanded autologous IL-8 receptor (CXCR2) modified CD70 CAR (8R-70CAR) T cells - High-grade Glioma, Diffuse Intrinsic Pontine Glioma | Phase 1 | Not yet recruiting | University of Florida | 24 | 2027-01-01 | 2026-10-30 |
| 4SCAR-T Therapy Targeting GD2, PSMA and CD276 for Treating Neuroblastoma GD2, PSMA and CD276 CAR-T cells - Neuroblastoma | Phase 1 / Phase 2 | Not yet recruiting | Shenzhen Geno-Immune Medical Institute | 100 | 2026-12-31 | 2026-10-30 |
| Immune Modulatory DC Vaccine Against Brain Tumor Immunomodulatory DC vaccine to target DIPG and GBM - Diffuse Intrinsic Pontine Glioma or Glioblastoma | Phase 1 | Not yet recruiting | Shenzhen Geno-Immune Medical Institute | 10 | 2026-12-31 | 2026-10-30 |
| Circadian-Optimized Light Therapy for the Treatment of Patients With Advanced Melanoma Receiving Tumor-Infiltrating Lymphocyte Therapy Biospecimen Collection, Internet-Based Intervention, Medical Device Usage and Evaluation - Advanced Cutaneous Melanoma, Clinical Stage III Cutaneous Melanoma AJCC v8 | Phase 1 | Not yet recruiting | City of Hope Medical Center | 8 | 2026-12-23 | 2026-06-05 |
| Testing the Combination of Anti-cancer Drugs Actimab-A and Cemiplimab (REGN2810) to Improve Outcomes for Patients With Recurrent Glioblastoma Actinium Ac 225 Lintuzumab, Biospecimen Collection, Cemiplimab - Recurrent Glioblastoma, IDH-Wildtype, Recurrent Gliosarcoma | Phase 1 | Not yet recruiting | National Cancer Institute (NCI) | 30 | 2026-12-04 | 2026-06-12 |
Showing 20 of 2838. Sign in to see all of them.
Melanoma (1215) · Glioblastoma (818) · Glioma (492) · Brain Neoplasms (382) · Carcinoma, Non-Small-Cell Lung (335) · Astrocytoma (315) · Neoplasms (290) · Neuroblastoma (260) · Gliosarcoma (247) · Carcinoma, Renal Cell (218) · Neoplasm Metastasis (212) · Central Nervous System Neoplasms (208) · Oligodendroglioma (192) · Breast Neoplasms (181) · Colorectal Neoplasms (174)
Neoplasms, Nerve Tissue (2829) · Neoplasms by Histologic Type (2828) · Neoplasms, Germ Cell and Embryonal (2807) · Neoplasms (2548) · Neoplasms by Site (1957) · Neoplasms, Glandular and Epithelial (1890) · Neoplasms, Neuroepithelial (1438) · Neuroendocrine Tumors (1365) · Skin and Connective Tissue Diseases (1286) · Skin Diseases (1284) · Nevi and Melanomas (1256) · Skin Neoplasms (1177) · Glioma (691) · Nervous System Diseases (612)
Temozolomide (259) · pembrolizumab (203) · Nivolumab (156) · Cyclophosphamide (146) · Radiotherapy (136) · Ipilimumab (125) · Bevacizumab (77) · fludarabine (68) · aldesleukin (65) · Interleukin-2 (63) · Radiation (63) · Magnetic Resonance Spectroscopy (60) · Carboplatin (56) · Irinotecan (52) · Specimen Handling (44)
National Cancer Institute (NCI) (225) · M.D. Anderson Cancer Center (87) · Memorial Sloan Kettering Cancer Center (46) · Novartis Pharmaceuticals (46) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (35) · Pfizer (28) · City of Hope Medical Center (27) · Duke University (27) · Hoffmann-La Roche (27) · Dana-Farber Cancer Institute (26) · H. Lee Moffitt Cancer Center and Research Institute (25) · Children's Oncology Group (23) · Mayo Clinic (23) · St. Jude Children's Research Hospital (22) · Jonsson Comprehensive Cancer Center (21)
United States (2065) · China (199) · Spain (191) · France (188) · Australia (181) · Canada (169) · United Kingdom (147) · Germany (146) · Italy (112) · Netherlands (96) · Belgium (81) · Switzerland (79) · South Korea (68) · Japan (59) · Israel (49)
Steven A Rosenberg, M.D. (11) · John Boockvar, MD (8) · Annick Desjardins, MD (7) · Daniel Landi, MD (7) · Steven A. Rosenberg, MD, PhD (7)
PMID 31401903, PMID 36648215, PMID 24577748, PMID 32747469, PMID 35468680, PMID 12749708, PMID 19171714, PMID 22256804, PMID 22658127, PMID 23377664, PMID 23545055, PMID 23676418, PMID 23724867, PMID 24983357, PMID 25837513, PMID 32078016, PMID 32350119, PMID 34132224, PMID 34171339, PMID 34311780, PMID 36746511, PMID 37072349, PMID 37082579, PMID 37142373, PMID 37640679, PMID 37934000, PMID 38172595, PMID 39462179, PMID 39504507, PMID 40721981, PMID 41218853, PMID 41920422, PMID 42580817, PMID 10394416, PMID 10797354, PMID 10811235, PMID 10890744, PMID 11118469, PMID 11410496, PMID 11595689, PMID 11874634, PMID 12039921, PMID 12091876, PMID 12218188, PMID 12573762, PMID 12576434, PMID 12675312, PMID 12684398, PMID 12721262, PMID 12749710
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