6 completed, 3 active not recruiting, 1 not yet recruiting, 1 recruiting. 12 Phase 2, 2 Phase 1, 2 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 12 | Completed 6, Active not recruiting 3, Not yet recruiting 1, Recruiting 1, Unknown 1 |
| Phase 1 | 2 | Completed 2 |
| Phase 3 | 2 | Completed 1, Unknown 1 |
Follow Mpox, Monkeypox: new trials by email Literature Review of Mpox, Monkeypox trials Research Report on Mpox, Monkeypox
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Randomized Clinical Trial Investigating the Safety, Reactogenicity, and Immunogenicity After Immunization With an mRNA-based Mpox Vaccine Candidate in Africa BNT166a, Placebo - Mpox (Monkeypox), Smallpox | Phase 2 | Recruiting | BioNTech SE | 310 | 2026-02-20 | 2026-08-11 |
| Evaluate the Safety and Immunogenicity of the MVA-SIBP Vaccine in the Democratic Republic of the Congo MVA-SIBP low dose, MVA-SIBP high dose, MVA-BN - Monkeypox (Mpox) | Phase 2 | Not yet recruiting | Shanghai Institute Of Biological Products | 180 | 2025-12-31 | 2025-11-28 |
| Comparability Trial of the MVA-BN Vaccine Manufactured in Different Production Cells Jynneos, MVA-BN (Quail) - Monkeypox (Mpox) | Phase 2 | Active not recruiting | Bavarian Nordic | 970 | 2025-10-27 | 2026-04-08 |
| An Immunogenicity and Safety Trial of MVA-BN in Adults Living With HIV for the Prevention of Mpox Infection, in Kinshasa, DRC Mpox vaccination with MVA-BN - Mpox (Monkeypox) | Phase 2 | Active not recruiting | Institute of Tropical Medicine, Belgium | 600 | 2025-08-04 | 2026-05-19 |
| Open-label, Multicenter Immunogenicity and Safety Study of MVA-BN Vaccine in Children From 2 Years to Less Than 12 Years of Age Compared to Adults for the Prevention of Smallpox, Mpox, and Related Orthopoxvirus Infections MVA-BN - Monkeypox (Mpox) | Phase 2 | Active not recruiting | Bavarian Nordic | 460 | 2024-10-21 | 2025-11-24 |
| A Clinical Study Investigating the Safety and Immune Responses After Immunization With Investigational Monkeypox Vaccines BNT166a - Monkeypox | Phase 1 / Phase 2 | Completed | BioNTech SE | 96 | 2023-09-21 | 2026-09-15 |
| A Study to Investigate The Safety, Tolerability, And Immune Response of a Range of Doses of mRNA-1769 Compared With Placebo in Healthy Participants From ≥18 Years of Age to <50 Years of Age mRNA-1769, Placebo - Smallpox, Mpox | Phase 1 / Phase 2 | Completed | ModernaTX, Inc. | 351 | 2023-08-15 | 2025-07-16 |
| A Phase 2 Randomized Multisite Trial to Inform Public Health Strategies Involving the Use of MVA-BN Vaccine for Mpox JYNNEOS - Monkeypox | Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 450 | 2023-03-22 | 2026-03-27 |
| Tecovirimat for Treatment of Monkeypox Virus Tecovirimat Oral Capsule, Placebo - Monkeypox | Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 597 | 2022-10-10 | 2025-10-09 |
| Trial to Evaluate the Immunogenicity of Dose Reduction Strategies of the MVA-BN Monkeypox Vaccine JYNNEOS - Monkeypox | Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 229 | 2022-09-09 | 2026-04-16 |
| Study on Immunogenicity, Reactogenicity and Safety of the VACΔ6 Vaccine in Volunteers Aged 18-60 Years VAC∆6 vaccine (10⁷ PFU), VAC∆6 vaccine (10⁶ PFU), Live Smallpox Vaccine - Smallpox, Monkeypox | Phase 2 / Phase 3 | Completed | Federal Budgetary Research Institution State Research Center of Virology and Biotechnology "Vector" | 334 | 2021-10-01 | 2023-05-06 |
| FOS Immunohistochemical Staining of Colorectal Cancer and Its Adjacent Tissues Immunohistochemical staining with anti-FOS - Colorectal Cancer, Monkey Pox | Phase 2 / Phase 3 | Unknown | xiaoliang Huang | 120 | 2020-12-01 | 2023-01-26 |
Smallpox (3) · Colorectal Neoplasms (1) · Cowpox (1) · Poxviridae Infections (1)
Animal Diseases (12) · DNA Virus Infections (12) · Infections (12) · Primate Diseases (12) · Rodent Diseases (12) · Virus Diseases (12) · Poxviridae Infections (11) · Colonic Diseases (1) · Digestive System Diseases (1) · Digestive System Neoplasms (1) · Gastrointestinal Diseases (1) · Gastrointestinal Neoplasms (1) · Intestinal Diseases (1) · Intestinal Neoplasms (1) · Neoplasms (1)
smallpox and monkeypox vaccine modified vaccinia ankara-bavarian nordic (6) · tecovirimat (1)
National Institute of Allergy and Infectious Diseases (NIAID) (3) · Bavarian Nordic (2) · BioNTech SE (2) · Federal Budgetary Research Institution State Research Center of Virology and Biotechnology "Vector" (1) · Institute of Tropical Medicine, Belgium (1) · ModernaTX, Inc. (1) · Shanghai Institute Of Biological Products (1) · xiaoliang Huang (1)
Democratic Republic of the Congo (4) · United States (4) · United Kingdom (2) · China (1) · Puerto Rico (1) · Russia (1) · South Africa (1) · Uganda (1)
Hypolite Muhindo Mavoko (1) · Irina V Krasil'nikova, PhD (1) · Jean-Jacques Muyembe-Tamfum, MD PhD (1) · Laurens Liesenborghs, MD (1) · Vladimir I. Kuzubov, PhD (1)
PMID 38366591, PMID 40239067, PMID 41319397, PMID 42235570, PMID 42372625, PMID 42532635