24 completed, 13 recruiting, 9 active not recruiting, 8 unknown. 12 Phase 2, 9 Phase 3, 8 Not applicable, 8 Phase 1, 4 Phase 4.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Smart Analysis and Decision-Making for Emerging Infectious Diseases Multi-Agent Integrated Smart Toolkit for Emerging Infectious Diseases, Routine Practices - Emerging Infectious Diseases, COVID-19 | Not applicable | Enrolling by invitation | Peking University | 108 | 2026-08-10 | 2026-08-19 |
| Assessment of Immune Memory - Humoral and Cellular - in mPOX-infected Patients : an Ancillary Study of the ANRS0258s MOSAIC Cohort blood sampling - Mpox (Monkeypox) | Not applicable | Not yet recruiting | ANRS, Emerging Infectious Diseases | 60 | 2026-07-01 | 2026-05-18 |
| Performance Evaluation of Mpox Molecular POC Diagnostics MPOX IVD test - Monkey Pox | Completed | Foundation for Innovative New Diagnostics, Switzerland | 80 | 2026-06-18 | 2026-09-04 | |
| Mpox Biology, Outcome, Transmission and Epidemiology - Tracking the Immune Response After mpoX vaCcination (MBOTE-TRAXX): Clinical Study to Monitor the Immunological Response Following Mpox Vaccination in the City of Kinshasa, Democratic Republic of the Congo blood sample collection - Mpox | Phase 4 | Active not recruiting | Institute of Tropical Medicine, Belgium | 300 | 2026-05-15 | 2026-06-11 |
| Validation of SDS-EDTA-Treated Chromatography Paper Strips for Mpox Sampling and Transport in DRC SDS-EDTA-treated chromatography strip - Mpox | Recruiting | Universitaire Ziekenhuizen KU Leuven | 150 | 2026-05-01 | 2026-06-11 | |
| Understanding MPXV Viral Clearance, Transmission Dynamics, and Mpox Vaccine Effectiveness in West Africa : Guinea Mpox (Monkeypox), Monkeypox | Not yet recruiting | London School of Hygiene and Tropical Medicine | 992 | 2026-04-16 | 2026-04-16 | |
| A Randomized Clinical Trial Investigating the Safety, Reactogenicity, and Immunogenicity After Immunization With an mRNA-based Mpox Vaccine Candidate in Africa BNT166a, Placebo - Mpox (Monkeypox), Smallpox | Phase 2 | Recruiting | BioNTech SE | 310 | 2026-02-20 | 2026-08-11 |
| Prospective Follow-up After MVA-BN Booster Vaccination Monkeypox (Mpox) | Not yet recruiting | Institute of Tropical Medicine, Belgium | 95 | 2026-01-15 | 2026-01-20 | |
| Evaluate the Safety and Immunogenicity of the MVA-SIBP Vaccine in the Democratic Republic of the Congo MVA-SIBP low dose, MVA-SIBP high dose, MVA-BN - Monkeypox (Mpox) | Phase 2 | Not yet recruiting | Shanghai Institute Of Biological Products | 180 | 2025-12-31 | 2025-11-28 |
| Evaluation of Effectiveness and Safety of LC16m8 Mpox Vaccine in the Democratic Republic of Congo (DRC) LC16m8 - Mpox (Monkeypox), Mpox | Recruiting | International Vaccine Institute | 11990 | 2025-12-03 | 2026-08-31 | |
| Investigating MPXV Viral Clearance in Mpox Cases and Secondary Attack Rate in Contacts Mpox (Monkeypox) | Completed | Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia | 550 | 2025-10-31 | 2026-05-01 | |
| Comparability Trial of the MVA-BN Vaccine Manufactured in Different Production Cells Jynneos, MVA-BN (Quail) - Monkeypox (Mpox) | Phase 2 | Active not recruiting | Bavarian Nordic | 970 | 2025-10-27 | 2026-04-08 |
| Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of BSY001 After Single/Multiple Doses. BSY001 for Injection (37.5mg), BSY001 for Injection (75 mg), BSY001 for Injection (150 mg) - Smallpox, Cowpox | Phase 1 | Recruiting | China National Biotec Group Company Limited | 76 | 2025-08-28 | 2026-01-29 |
| Neutralizing Power of Serum Antibodies - 2 Sample collection (blood and optional nasal swab) - COVID-19, SARS-CoV-2 Viraemia | Not applicable | Recruiting | Centre Hospitalier Régional d'Orléans | 30 | 2025-08-22 | 2025-12-19 |
| An Immunogenicity and Safety Trial of MVA-BN in Adults Living With HIV for the Prevention of Mpox Infection, in Kinshasa, DRC Mpox vaccination with MVA-BN - Mpox (Monkeypox) | Phase 2 | Active not recruiting | Institute of Tropical Medicine, Belgium | 600 | 2025-08-04 | 2026-05-19 |
| Epidemiological and Clinical Characteristics of Human Mpox Outbreak in Equateur Province in the Democratic Republic of Congo (Part3) Mpox (Monkeypox) | Enrolling by invitation | Osaka Metropolitan University | 144 | 2025-07-31 | 2025-05-29 | |
| Phase 3 Maternal Safety & Immunogenicity Trial of MVA-BN® in DRC MVA-BN standard regimen, MVA-BN standard regimen (Administered as PEP) - Neonate, Maternal Transmission | Phase 3 | Active not recruiting | Jean-Pierre Van geertruyden | 359 | 2025-06-23 | 2026-01-30 |
| Phase 3 Infant Safety & Immunogenicity Trial of MVA-BN® in DRC MVA-BN standard regimen, MVA-BN half-dose regimen - Mpox (Monkeypox), Vaccination | Phase 3 | Active not recruiting | Jean-Pierre Van geertruyden | 344 | 2025-05-29 | 2026-04-29 |
| Evaluation of Long-term Immunogenicity of a Boost Dose of MVA-BN Vaccine Monkeypox | Recruiting | Assistance Publique - Hôpitaux de Paris | 90 | 2025-05-07 | 2025-05-15 | |
| Epidemiological and Pathophysiological Insights Through a Cross-sectional Survey (EPIC) Monkeypox (Mpox) | Recruiting | Institute of Tropical Medicine, Belgium | 1000 | 2025-03-28 | 2025-05-02 |
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Mpox, Monkeypox (72) · Smallpox (11) · Cowpox (4) · HIV Infections (3) · Infections (3) · Poxviridae Infections (3) · COVID-19 (2) · Vaccinia (2) · Acquired Immunodeficiency Syndrome (1) · Chikungunya Fever (1) · Coitus (1) · Colorectal Neoplasms (1) · Communicable Diseases, Emerging (1) · DNA Virus Infections (1) · Dengue (1)
Animal Diseases (72) · Primate Diseases (72) · DNA Virus Infections (71) · Virus Diseases (71) · Infections (69) · Poxviridae Infections (69) · RNA Virus Infections (5) · Communicable Diseases (4) · Blood-Borne Infections (3) · Genital Diseases (3) · Immune System Diseases (3) · Immunologic Deficiency Syndromes (3) · Lentivirus Infections (3) · Retroviridae Infections (3)
smallpox and monkeypox vaccine modified vaccinia ankara-bavarian nordic (10) · tecovirimat (8) · Blood Specimen Collection (4) · Smallpox Vaccine (2) · Surveys and Questionnaires (2) · smallpox vaccine LC16m8 (2) · Injections (1) · MVA vaccine (1) · NIOCH-14 (1) · Sampling Studies (1) · Specimen Handling (1) · Standard of Care (1) · Vaccination (1)
Institute of Tropical Medicine, Belgium (9) · National Institute of Allergy and Infectious Diseases (NIAID) (7) · Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia (4) · ANRS, Emerging Infectious Diseases (3) · Assistance Publique - Hôpitaux de Paris (3) · Federal Budgetary Research Institution State Research Center of Virology and Biotechnology "Vector" (3) · Osaka Metropolitan University (3) · Bavarian Nordic (2) · BioNTech SE (2) · Centers for Disease Control and Prevention (2) · Institut Pasteur (2) · Jean-Pierre Van geertruyden (2) · Shanghai Institute Of Biological Products (2) · Unity Health Toronto (2) · Beni-Suef University (1)
Democratic Republic of the Congo (22) · United States (11) · France (7) · Spain (6) · Belgium (4) · China (4) · United Kingdom (4) · Brazil (3) · Canada (3) · Russia (3) · Uganda (3) · Argentina (2) · Mexico (2) · Netherlands (2) · Nigeria (2)
Laurens Liesenborghs, MD (3) · Vladimir I. Kuzubov, PhD (3) · Jean-Jacques Muyembe-Tamfum, MD PhD (2) · Yasutoshi Kido, Professor (2) · Agam Rao, MD (1) · Angelica Kottkamp, MD (1) · Brian Epling, MD (1) · Christine Hughes, PhD (1) · Christopher Green (1) · Christopher Meadows, FRCP FRCA (1) · Darrell HS Tan, MD (1) · Deborah Watson-Jones, PhD (1) · Edward M Choi, PhD (1)
PMID 36263798, PMID 42372625, PMID 30445121, PMID 37212312, PMID 38366591, PMID 40162783, PMID 40239067, PMID 40245474, PMID 41319397, PMID 41688920, PMID 41740032, PMID 41819114, PMID 41819117, PMID 42209512, PMID 42235570, PMID 42521300, PMID 42532635