5 recruiting, 4 not yet recruiting, 1 completed, 1 withdrawn. 4 Not applicable, 3 Phase 1, 2 Phase 2, 1 Early Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 4 | Recruiting 2, Completed 1, Not yet recruiting 1 |
| Phase 1 | 3 | Recruiting 2, Withdrawn 1 |
| Phase 2 | 2 | Not yet recruiting 1, Recruiting 1 |
| Early Phase 1 | 1 | Not yet recruiting 1 |
Follow Malignant Pleural Effusions (Mpe): new trials by email Literature Review of Malignant Pleural Effusions (Mpe) trials Research Report on Malignant Pleural Effusions (Mpe)
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Union-LC-MPE Cohort:A Multicenter Cohort Study on Diagnosis and Prognosis of Malignant Pleural Effusion in Lung Cance Malignant Pleural Effusions (Mpe), Lung Cancer (Diagnosis) | Not yet recruiting | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | 3000 | 2026-10-01 | 2026-10-20 | |
| Safety and Feasibility of Medical Thoracoscopy Using Single-use Flexible Bronchoscope Versus SemiRigid Pleuroscope in Pleural Effusion Single-Use Flexible Bronchoscope, Semi-Rigid Pleuroscope - Malignant Pleural Effusions (Mpe), Medical Thoracoscopy | Not applicable | Recruiting | National University of Malaysia | 36 | 2026-08-20 | 2026-09-11 |
| A Phase II Study to Evaluate JMKX000197 Injection Versus Cisplatin in the Treatment of Malignant Pleural Effusion JMKX000197, Cisplatin - Malignant Pleural Effusions (Mpe) | Phase 2 | Not yet recruiting | Shanghai Jeyou Pharmaceutical Co., Ltd. | 120 | 2026-08-17 | 2026-06-16 |
| Xuan Yin Ning Plus Bevacizumab for Malignant Pleural Effusion Treatment with Xuanyin Ning Formula combined with intrapleural injection of bevacizumab via chest tube drainage, Placebo granules plus chest tube drainage and intrapleural bevacizumab injection - Malignant Pleural Effusions (Mpe) | Not applicable | Not yet recruiting | Shanghai Chest Hospital | 308 | 2026-06-01 | 2026-07-01 |
| First-in-Human Expanded Cohort Study of Intrapleural Administration of TolueneSulfonamide in Patients With Malignant Pleural Effusion Intrapleural administration of TolueneSulfonamide, Intrapleural administration of normal saline injection - Malignant Pleural Effusions (Mpe), Non Small Cell Lung Cancer | Phase 1 / Phase 2 | Recruiting | Gang Hou | 105 | 2026-04-24 | 2026-05-15 |
| ARMSTRONG - Air entRainMent vS sTandard tReatment in nOn-expandable luNG Air Entrainment - intentional introduction of the atmospheric air into the pleural space. - Non-expandable Lung, Trapped Lung | Not applicable | Recruiting | Cambridge University Hospitals NHS Foundation Trust | 41 | 2025-04-14 | 2025-05-07 |
| The Outcome of Inserting Intercostal Tube or Pleurodesis for Malignant Pleural Effusion Intercostal chest tube, Pleurodesis - Malignant Pleural Effusions (Mpe) | Early Phase 1 | Not yet recruiting | Assiut University | 20 | 2024-12-30 | 2024-12-19 |
| A Phase Ib Study of JMKX000197 Injection in the Treatment of Malignant Pleural Effusion JMKX000197, Tube thoracostomy drainage - Malignant Pleural Effusions (Mpe) | Phase 1 | Recruiting | Jemincare | 30 | 2024-12-28 | 2025-04-04 |
| Phase I Evaluation of Immunotoxin LMB-100 Administered by Normothermic, Intrapleural Perfusion Following Cytoreductive Surgery in Participants With Pleural Mesotheliomas, or Pleural Effusions From Cancers Expressing Mesothelin Cytoreductive surgery, LMB-100, Immunohistochemical Assay for Mesothelin - Malignant Pleural Mesotheliomas (Mpm), Malignant Pleural Effusions (Mpe) | Phase 1 | Withdrawn | National Cancer Institute (NCI) | 2024-01-31 | 2024-02-02 | |
| Impact of Pleural Manometry on the Assessment and Treatment of Malignant Pleural Effusion: A Pilot Clinical Trial Pleural manometry - Malignant Pleural Effusions (Mpe) | Not applicable | Completed | Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau | 55 | 2023-07-28 | 2026-10-16 |
| Ex Vivo Drug Response Profiling and Outcome Prediction in Lung Adenocarcinoma Non-Interventional Study - Lung Adenocarcinoma, Malignant Pleural Effusions (Mpe) | Recruiting | Sheba Medical Center | 400 | 2023-06-14 | 2026-06-23 |
Myeloproliferative Disorder, Chronic, with Eosinophilia (11) · Pleural Effusion, Malignant (11) · Lung Neoplasms (2) · Pleural Effusion (2) · Adenocarcinoma of Lung (1) · Carcinoma (1) · Carcinoma, Non-Small-Cell Lung (1) · Disease (1) · Mesothelioma, Malignant (1)
Neoplasms (11) · Neoplasms by Site (11) · Pleural Diseases (11) · Pleural Neoplasms (11) · Respiratory Tract Diseases (11) · Respiratory Tract Neoplasms (11) · Thoracic Neoplasms (11) · Pleural Effusion (9) · Lung Diseases (4) · Lung Neoplasms (2) · Neoplasms by Histologic Type (2) · Neoplasms, Glandular and Epithelial (2) · Adenocarcinoma (1) · Adenoma (1) · Bronchial Neoplasms (1)
Cisplatin (1) · Cytoreduction Surgical Procedures (1) · LMB-100 (1) · Pleurodesis (1) · Therapeutics (1)
Assiut University (1) · Cambridge University Hospitals NHS Foundation Trust (1) · Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau (1) · Gang Hou (1) · Jemincare (1) · National Cancer Institute (NCI) (1) · National University of Malaysia (1) · Shanghai Chest Hospital (1) · Shanghai Jeyou Pharmaceutical Co., Ltd. (1) · Sheba Medical Center (1) · Union Hospital, Tongji Medical College, Huazhong University of Science and Technology (1)
China (5) · Egypt (1) · Israel (1) · Malaysia (1) · Spain (1) · United Kingdom (1) · United States (1)
David S Schrump, M.D. (1) · Gang Hou, PhD (1) · Jie Wang (1) · Mohamed Faisal Abdul Hamid, MBBS(IIUM) (1) · Ning Li (1)