3 completed, 2 recruiting. 5 Phase 2, 2 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 5 | Completed 3, Recruiting 2 |
| Phase 3 | 2 | Completed 1, Recruiting 1 |
Follow Lymphatic Malformations: new trials by email Literature Review of Lymphatic Malformations trials Research Report on Lymphatic Malformations
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Phase 2 Study of Mutant-selective PI3Kα Inhibitor, RLY-2608, in Adults and Children With PIK3CA Related Overgrowth Spectrum and Malformations Driven by PIK3CA Mutation (The ReInspire Study) RLY-2608, Placebo - PIK3CA-Related Overgrowth Spectrum (PROS), Lymphatic Malformations | Phase 2 | Recruiting | Relay Therapeutics, Inc. | 277 | 2025-06-13 | 2026-11-12 |
| Alpelisib in Pediatric and Adult Patients With Lymphatic Malformations Associated With a PIK3CA Mutation. Alpelisib, Placebo - Lymphatic Malformations | Phase 2 / Phase 3 | Recruiting | Novartis Pharmaceuticals | 232 | 2023-11-24 | 2026-10-09 |
| Sildenafil for the Treatment of Lymphatic Malformations Sildenafil 20 mg tablets, Placebo tablets (resembling Revatio) - Lymphatic Malformations, Lymphatic Diseases | Phase 2 | Completed | Stanford University | 22 | 2015-05-23 | 2022-11-17 |
| OK432 (Picibanil) in the Treatment of Lymphatic Malformations OK432 - Lymphatic Malformations | Phase 2 | Completed | Richard JH Smith | 275 | 2005-10-05 | 2021-11-23 |
| Study of Picibanil (OK432) Sclerotherapy in Children With Macrocystic Lymphatic Malformations picibanil - Lymphatic Malformations | Phase 2 / Phase 3 | Completed | University of Iowa | 150 | 2000-04-01 | 2015-03-25 |
Lymphatic Abnormalities (5) · Lymphangioma (2) · Lymphangioma, Cystic (2) · Congenital Lipomatous Overgrowth, Vascular Malformations, and Epidermal Nevi (1) · Klippel-Trenaunay-Weber Syndrome (1) · Lymphatic Diseases (1) · Megalencephaly cutis marmorata telangiectatica congenita (1) · Vascular Malformations (1)
Congenital Abnormalities (5) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (5) · Hemic and Lymphatic Diseases (5) · Lymphatic Diseases (4) · Neoplasm, Lymphatic Tissue (2) · Neoplasms (2) · Neoplasms by Histologic Type (2) · Angiomatosis (1) · Cardiovascular Abnormalities (1) · Cardiovascular Diseases (1) · Vascular Diseases (1)
Picibanil (2) · Alpelisib (1) · Sildenafil Citrate (1)
Novartis Pharmaceuticals (1) · Relay Therapeutics, Inc. (1) · Richard JH Smith (1) · Stanford University (1) · University of Iowa (1)
United States (5) · Australia (2) · Belgium (2) · France (2) · Germany (2) · Italy (2) · Spain (2) · United Kingdom (2) · Argentina (1) · Czechia (1) · Ireland (1) · Netherlands (1) · Norway (1) · Switzerland (1)
Joyce Teng, MD, PhD (1) · Richard J Smith (1) · Richard JH Smith, MD (1)
2023 (1)