10 unknown, 6 completed, 3 withdrawn, 2 recruiting. 9 Phase 2, 7 Not applicable, 2 Phase 1, 2 Phase 3.
Follow Lung Cancer Stage IV: new trials by email Literature Review of Lung Cancer Stage IV trials Research Report on Lung Cancer Stage IV
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Screening for Brain Metastases gadopiclenol (contrast agent), standard contrast agent - Lung Cancer Stage IV, Melanoma Stage IV | Phase 2 | Not yet recruiting | University of Zurich | 180 | 2026-09-01 | 2026-03-25 |
| BL-M14D1 Plus Atezolizumab vs Standard of Care in First-Line Extensive-Stage Small Cell Lung Cancer (BrenDeLL-Lung01) BL-M14D1 and Atezolizumab, Carboplatin+ Etoposide + Atezolizumab followed by Atezolizumab and Lurbinectedin - Small Cell Lung Cancer Extensive Stage, Small-cell Lung Cancer | Phase 3 | Recruiting | SystImmune Inc. | 550 | 2026-08-04 | 2026-10-15 |
| Re-induction of a Systemic Immune Response in Metastatic or Locally Recurrent Lung Cancer Radiation - Lung Cancer Stage IV | Phase 2 | Withdrawn | Maastricht Radiation Oncology | 2024-12-01 | 2024-09-19 | |
| Characteristics of Advanced LUNG CANCER at the tIme of Diagnosis in a Large Italian Cohor Advanced lung cancer patients' group - Lung Cancer Stage IV | Recruiting | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 1000 | 2023-11-01 | 2025-09-02 | |
| Prognostic Value of Combined Approach Based on KEAP1/NFE2L2 Mutations and Pre-therapeutic FDG-PET/CT Radiomic Analysis in Advanced Non-small-cell Lung Cancer PDL1 ≥ 50% Treated With Pembrolizumab (PEMBROMIC) Lung Cancer Stage III, Lung Cancer Stage IV | Unknown | University Hospital, Brest | 75 | 2023-08-01 | 2024-08-09 | |
| Testing Experimental Anti-cancer Drug SLC-391 With an Approved Immunotherapy Drug, Pembrolizumab, for Advanced Lung Cancers SLC-391, pembrolizumab - Lung Cancer, Nonsmall Cell, Lung Cancer Stage IV | Phase 1 / Phase 2 | Terminated | SignalChem Lifesciences Corporation | 36 | 2023-05-31 | 2025-12-18 |
| The Effect of Combined Cryotherapy and Immunotherapy on Systemic T Cell Changes and Clinical Outcomes in Metastatic Non-small Cell Lung Cancer Bronchoscopic cryotherapy, Pembrolizumab, Platinum based chemotherapy - Lung Cancer Stage IV | Not applicable | Unknown | Lithuanian University of Health Sciences | 120 | 2023-04-01 | 2023-08-21 |
| Lazertinib 160mg in EGFR T790M NSCLC Lazertinib - Lung Cancer Stage IV, EGFR T790M | Phase 2 | Unknown | Samsung Medical Center | 117 | 2023-02-01 | 2023-01-27 |
| Psychosocial eHealth in Advanced Lung Cancer E-health ecosystem of stepped psychosocial care, Usual psychosocial care - Lung Cancer, Nonsmall Cell, Stage IIIA, Lung Cancer Non-Small Cell Stage IIIB | Not applicable | Unknown | Institut Català d'Oncologia | 152 | 2022-11-15 | 2023-09-29 |
| Sotorasib in Advanced KRASG12C-mutated Non-small Cell Lung Cancer Patients With Comorbidities sotorasib - Lung Cancer, NSCLC, Stage III | Phase 2 | Unknown | Vestre Viken Hospital Trust | 100 | 2022-05-30 | 2023-11-09 |
| Efficacy of SRT as Salvage Therapy in Patients With Brain Oligo-progression of EGFR-mutant Non-small Cell Lung Cancer After Failure of the Third-generation EGFR-TKIs Aumolertinib Oral Tablet - Lung Cancer Stage IV | Phase 2 | Unknown | Shanghai Cancer Hospital, China | 40 | 2022-01-01 | 2023-03-20 |
| Stereotactic Body Radiotherapy for Lung Lesions With Markerless Tracking (MLT) on the VERO® SBRT System Standard radiotherapy treatment - Lung Cancer, Stereotactic Body Radiotherapy | Withdrawn | Universitair Ziekenhuis Brussel | 2022-01-01 | 2024-12-09 | ||
| Resilience Measurement in Older Adults With Late-Stage Lung Cancer Self System Therapy for Older Adults with Advanced Lung Cancer (SST-LC) Resilience - Lung Cancer Stage III, Lung Cancer Stage IV | Not applicable | Completed | Duke University | 18 | 2021-05-03 | 2024-02-02 |
| Comparing Different Sizes of Small-bore Chest Drains in Malignant Pleural Effusion Seldinger chest drain insertion - Pleural Effusion, Malignant, Lung Cancer Stage IV | Not applicable | Terminated | The University of Hong Kong | 52 | 2020-12-01 | 2025-03-28 |
| Self-System Therapy for Older Adults With Lung Cancer Self-System Therapy for Older Adults with Advanced Lung Cancer (SST-LC) - Lung Cancer Stage III, Lung Cancer Stage IV | Not applicable | Completed | Duke University | 30 | 2020-04-02 | 2022-08-03 |
| Liver Toxicity in Lung Cancer Patients Treated With Immune-checkpoint Inhibitors. No intervention due to observational methods of study - Lung Cancer Stage IV, Lung Cancer, Non-small Cell | Unknown | Western Sydney Local Health District | 500 | 2020-01-07 | 2022-01-21 | |
| Personalizing Immune Checkpoint Inhibitor Therapy Blood and tumor tissue analysis, Clinical response. - Lung Cancer Stage IV | Withdrawn | Holy Cross Hospital, Maryland | 2019-02-01 | 2020-09-24 | ||
| Nivolumab and Temozolomide in Treating Patients With Recurrent or Refractory Small-Cell Lung Cancer or Advanced Neuroendocrine Cancer Nivolumab, Temozolomide - Grade I Neuroendocrine Carcinoma, Grade II Neuroendocrine Carcinoma | Phase 2 | Completed | Dwight Owen | 55 | 2018-12-31 | 2026-08-18 |
| A Study of SHR-1210 in Combination With Carboplatin + Paclitaxel in Subjects With Squamous NSCLC SHR-1210, The placebo - Lung Cancer Squamous Cell, Lung Cancer Stage IV | Phase 3 | Unknown | Jiangsu HengRui Medicine Co., Ltd. | 390 | 2018-11-09 | 2021-03-15 |
| Feasibility of a Web-based Patient Reported Outcome Symptom Monitoring Application in Danish Lung Cancer Patients Weekly questionnaires - Lung Cancer Stage IV | Not applicable | Completed | Regional Hospital West Jutland | 20 | 2018-05-01 | 2018-08-29 |
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Lung Neoplasms (24) · Carcinoma, Non-Small-Cell Lung (6) · Neoplasms (2) · Small Cell Lung Carcinoma (2) · Adenocarcinoma of Lung (1) · Behavior (1) · Carcinoma, Neuroendocrine (1) · Carcinoma, Small Cell (1) · Hepatitis (1) · Lung Diseases (1) · Melanoma (1) · Neuroendocrine Tumors (1) · Patient Participation (1) · Pleural Effusion, Malignant (1)
Neoplasms by Site (24) · Respiratory Tract Diseases (24) · Respiratory Tract Neoplasms (24) · Thoracic Neoplasms (24) · Lung Diseases (23) · Neoplasms (22) · Bronchial Neoplasms (8) · Carcinoma, Bronchogenic (8) · Neoplasms by Histologic Type (4) · Carcinoma (3) · Neoplasms, Glandular and Epithelial (3) · Adenocarcinoma (2) · Neoplasms, Germ Cell and Embryonal (2) · Neoplasms, Nerve Tissue (2) · Neuroectodermal Tumors (2)
Aging (2) · Radiosurgery (2) · pembrolizumab (2) · Blood Specimen Collection (1) · Carboplatin (1) · Contrast Media (1) · EC regimen (1) · Erlotinib Hydrochloride (1) · Etoposide (1) · Nivolumab (1) · PM 01183 (1) · Platinum Compounds (1) · Radiation (1) · Temozolomide (1) · atezolizumab (1)
Duke University (2) · CancerCare Manitoba (1) · Dwight Owen (1) · Fondazione Policlinico Universitario Agostino Gemelli IRCCS (1) · Holy Cross Hospital, Maryland (1) · Institut Català d'Oncologia (1) · Jiangsu HengRui Medicine Co., Ltd. (1) · Lithuanian University of Health Sciences (1) · Maastricht Radiation Oncology (1) · Memorial Sloan Kettering Cancer Center (1) · Regional Hospital West Jutland (1) · Samsung Medical Center (1) · Shanghai Cancer Hospital, China (1) · Sichuan Cancer Hospital and Research Institute (1) · SignalChem Lifesciences Corporation (1)
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Katherine Ramos, Ph.D. (2) · Caicun Zhou, MD, PhD (1) · Christine Collen, MD (1) · Cristian Ochoa, PhD (1) · Dirk De Ruysscher, MD, PhD (1) · Dwight Owen, MD, MS (1) · Golo Ahlenstiel, Professor (1) · Helena Yu, MD (1) · Jianjun Zou, MD, PhD (1) · Junliang Cai, MD (1) · Mark De Ridder, MD, PhD (1) · Mei Sze Macy Lui, MD (1) · Odd Terje Brustugun, MD, PhD (1) · Rasmus Friis, MD (1) · Rocco Trisolini (1)
PMID 11451810, PMID 20696688, PMID 25874452, PMID 26720026, PMID 28344925, PMID 31917762, PMID 32554725, PMID 33234490, PMID 34923163, PMID 34980131, PMID 35278845, PMID 37273934, PMID 40940906, PMID 41471387