11 completed, 6 terminated, 3 unknown. 8 Phase 2, 6 Phase 1, 3 Not applicable, 2 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 8 | Terminated 4, Completed 3, Unknown 1 |
| Phase 1 | 6 | Completed 3, Terminated 2, Unknown 1 |
| Not applicable | 3 | Completed 2, Terminated 1 |
| Phase 3 | 2 | Completed 1, Unknown 1 |
Follow Leukemia, Lymphoblastic, Acute: new trials by email Literature Review of Leukemia, Lymphoblastic, Acute trials Research Report on Leukemia, Lymphoblastic, Acute
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Optimal Methods of Disease Detection in Children and Young Adults With Acute Lymphoblastic Leukemia in the Pediatric Oncology Branch Leukemia, Lymphoblastic, Acute, ALL, Childhood | Completed | National Cancer Institute (NCI) | 150 | 2018-08-02 | 2022-06-01 | |
| Cladribine Dose Escalation in Conditioning Regimen Prior to Allo-HSCT for Refractory Acute Leukemia and Myelodysplastic Syndromes Fludarabine-Cladribine-Busulfan conditioning regimen - Leukemia, Myeloid, Acute, Leukemia, Lymphoblastic, Acute | Phase 1 | Unknown | Institut Paoli-Calmettes | 29 | 2018-04-28 | 2018-06-28 |
| Observation of the Effect of Chemotherapy Combined With Tyrosinase Inhibitor on the Reactivation of CMV and EBV in Patients With Acute Lymphoblastic Leukemia TKIs - Leukemia, Lymphoblastic, Acute | Unknown | Nanfang Hospital, Southern Medical University | 100 | 2017-11-01 | 2017-11-08 | |
| Phase I, Dose Escalation Study of Decitabine Decitabine - Leukemia, Lymphoblastic, Acute, Leukemia, Myeloid Acute | Phase 1 | Completed | University of Florida | 3 | 2014-10-01 | 2018-10-15 |
| Use of Saline-Washed Platelet and Red Cell Transfusions in Adult Acute Leukemia Leukemia, Myeloid, Acute, Leukemia, Lymphoblastic, Acute | Completed | University of Rochester | 100 | 2011-03-01 | 2017-04-11 | |
| EZN-3042 Administered With Re-induction Chemotherapy in Children With Relapsed Acute Lymphoblastic Leukemia (ALL) EZN-3042, Cytarabine, Doxorubicin - Lymphoblastic Leukemia, Acute, Lymphoblastic Leukemia, Acute, Childhood | Phase 1 | Terminated | Therapeutic Advances in Childhood Leukemia Consortium | 6 | 2010-08-24 | 2024-02-01 |
| Clofarabine With Cytarabine for Patients With Minimal Residual Disease Positive Leukemia Clofarabine, Cytarabine intravenous, Methotrexate - Minimal Residual Disease, Leukemia, Lymphoblastic, Acute | Phase 2 | Terminated | Therapeutic Advances in Childhood Leukemia Consortium | 2 | 2010-08-01 | 2021-10-26 |
| MSC and HSC Coinfusion in Mismatched Minitransplants Mesenchymal stem cells, Isotonic solution - Leukemia, Myeloid, Acute, Leukemia, Lymphoblastic, Acute | Phase 2 | Terminated | University of Liege | 39 | 2010-07-01 | 2021-09-08 |
| Effects of Methylphenidate on Attention Deficits in Childhood Cancer Survivors Methylphenidate, Placebo - ALL, Childhood, Leukemia, Lymphoblastic | Not applicable | Terminated | University of Minnesota | 1 | 2010-05-01 | 2015-03-27 |
| Unrelated Double Umbilical Cord Blood Units Transplantation Stem cell Transplantation - Leukemia, Myeloid, Acute, Leukemia, Lymphoblastic, Acute | Phase 2 / Phase 3 | Unknown | Tehran University of Medical Sciences | 10 | 2009-11-01 | 2012-06-04 |
| Pilot Study of Unrelated Cord Blood Transplantation Thiotepa, Fludarabine, Intravenous busulphan - Leukemia, Myeloid, Acute, Myelodysplastic Syndromes | Phase 2 | Terminated | King's College Hospital NHS Trust | 40 | 2009-09-01 | 2015-02-11 |
| Mismatched Donor Lymphocyte Infusions for Relapsed Disease Following Allogeneic Stem Cell Transplantation Miltenyi Magnetic cell sorter for CD3 - Leukemia, Myeloid, Acute, Leukemia, Lymphoblastic, Acute | Not applicable | Completed | National Heart, Lung, and Blood Institute (NHLBI) | 8 | 2009-02-01 | 2020-10-27 |
| Transplantation of Umbilical Cord Blood Following Chemotherapy for Blood Cancers Ex vivo expansion of cord blood - Acute Myeloid Leukemia, Leukemia, Lymphoblastic, Acute | Phase 1 / Phase 2 | Terminated | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 3 | 2007-12-20 | 2020-02-18 |
| "Geriatric Assessment Adapted" Therapy for Ph- ALL Elderly Patients Geriatric assessment adapted therapy, Stem cells autotransplantation - Leukemia, Lymphoblastic, Acute | Phase 2 | Completed | Gruppo Italiano Malattie EMatologiche dell'Adulto | 102 | 2007-11-01 | 2022-10-12 |
| Dasatinib and Low Intensity Chemotherapy for Ph+ Acute Lymphoblastic Leukemia Dasatinib - Leukemia, Lymphoblastic, Acute | Phase 2 | Completed | Versailles Hospital | 71 | 2007-08-01 | 2016-09-05 |
| Myeloablative Hematopoietic Progenitor Cell Transplantation (HPCT) for Pediatric Malignancies Myeloablative Chemotherapy Regimen for Lymphoid Malignancies or Cord Blood Unit Recipients, Myeloablative Chemotherapy Regimen for Non-Cord Blood Unit Recipients with Myeloid Malignancies, Hematopoietic Progenitor Cell Transplantation (HPCT) - Leukemia, Myelogenous, Chronic, Leukemia, Lymphoblastic, Acute | Completed | Ann & Robert H Lurie Children's Hospital of Chicago | 81 | 2007-03-26 | 2025-03-07 | |
| Feasibility of Haploidentical Hematopoietic Stem Cell Transplantation Using CAMPATH-1H Haploidentical hematopoietic stem cell transplantation, Busulfan, Cyclophosphamide - Leukemia, Myeloid, Acute, Leukemia, Lymphoblastic, Acute | Phase 1 | Completed | Tehran University of Medical Sciences | 10 | 2006-09-01 | 2008-11-18 |
| Study Evaluating AMD3100 for Transplantation of Sibling Donor Stem Cells in Patients With Hematological Malignancies AMD3100, Stem Cell Transplant - Leukemia, Myeloid, Acute, Leukemia, Myelogenous, Chronic | Phase 1 / Phase 2 | Completed | Washington University School of Medicine | 92 | 2004-05-01 | 2017-06-06 |
| A Severity-Adapted Clinical Trial of Diminished Bone Mineral Density in Acute Lymphoblastic Leukemia Survivors Calcium carbonate (Tums), vitamin D, Placebo - Leukemia, Lymphoblastic, Acute, Osteoporosis | Phase 3 | Completed | St. Jude Children's Research Hospital | 429 | 2000-07-01 | 2017-05-10 |
| Immunoablative Mini Transplant (Hematopoietic Peripheral Blood Stem Cell Transplant [HPBSC]) Immunoablative Hematopoietic PBSC Transplant, Busulfan pharmacokinetics, Central Nervous System (CNS) prophylaxis radiation - Tumors, Malignant Melanoma | Not applicable | Completed | Ann & Robert H Lurie Children's Hospital of Chicago | 68 | 2000-03-10 | 2019-08-30 |
Precursor Cell Lymphoblastic Leukemia-Lymphoma (20) · Leukemia, Myeloid, Acute (13) · Leukemia, Myelogenous, Chronic, BCR-ABL Positive (7) · Myelodysplastic Syndromes (7) · Leukemia, Lymphocytic, Chronic, B-Cell (4) · Hodgkin Disease (3) · Leukemia (3) · Lymphoma, Non-Hodgkin (3) · Recurrence (3) · Hematologic Neoplasms (2) · Multiple Myeloma (2) · Neoplasm, Residual (2) · Brain Neoplasms (1) · Graft vs Host Disease (1) · Leukemia, Myelomonocytic, Juvenile (1)
Hematologic Diseases (20) · Hemic and Lymphatic Diseases (20) · Immune System Diseases (20) · Immunoproliferative Disorders (20) · Leukemia, Lymphoid (20) · Lymphatic Diseases (20) · Lymphoproliferative Disorders (20) · Neoplasms by Histologic Type (20) · Neoplasms (19) · Leukemia (17) · Leukemia, Myeloid (13) · Pathologic Processes (12) · Pathological Conditions, Signs and Symptoms (12) · Disease Attributes (11) · Bone Marrow Diseases (10)
Methotrexate (3) · Busulfan (2) · Cyclophosphamide (2) · Cyclosporine (2) · Cytarabine (2) · Dasatinib (2) · Stem Cell Transplantation (2) · Alemtuzumab (1) · Calcium Carbonate (1) · Clofarabine (1) · Cortisone (1) · Decitabine (1) · Doxorubicin (1) · EZN 3042 (1) · Hydrocortisone (1)
Ann & Robert H Lurie Children's Hospital of Chicago (2) · Tehran University of Medical Sciences (2) · Therapeutic Advances in Childhood Leukemia Consortium (2) · Gruppo Italiano Malattie EMatologiche dell'Adulto (1) · Institut Paoli-Calmettes (1) · King's College Hospital NHS Trust (1) · Nanfang Hospital, Southern Medical University (1) · National Cancer Institute (NCI) (1) · National Heart, Lung, and Blood Institute (NHLBI) (1) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (1) · St. Jude Children's Research Hospital (1) · University of Florida (1) · University of Liege (1) · University of Minnesota (1) · University of Rochester (1)
United States (12) · Belgium (2) · France (2) · Iran (2) · Italy (2) · Australia (1) · China (1) · Germany (1) · United Kingdom (1)
Alicia Kunin-Batson, Ph.D. (1) · Allen R. Chen, MD,PhD. MHS (1) · Amir Ali Hamidieh, MD (1) · Antonio Pagliuca, MBBS, MA, FRCP, FRCPath (1) · Ardeshir Ghavamzadeh, MD (1) · Augustin Ferrant, MD, PhD (1) · Blythe Thomson, MD (1) · Carlos Graux, MD, PhD (1) · Chantal Doyen, MD, PhD (1) · Chantal Lechanteur, PhD (1) · Dominik Selleslag, MD, PhD (1) · Dominique Bron, MD, PhD (1) · Elizabeth Raetz, MD (1) · Etienne Baudoux, MD (1) · Evelyne Willems, MD (1)