2 recruiting, 1 completed. 2 Phase 1, 1 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 2 | Completed 1, Recruiting 1 |
| Not applicable | 1 | Recruiting 1 |
Follow Leptomeningeal Disease (LMD): new trials by email Literature Review of Leptomeningeal Disease (LMD) trials Research Report on Leptomeningeal Disease (LMD)
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study of SX-682 in Combination With Proton Craniospinal Irradiation (pCSI) in People With Leptomeningeal Disease SX-682, Proton Craniospinal Irradiation (pCSI) - Leptomeningeal Disease (LMD) | Phase 1 | Recruiting | Memorial Sloan Kettering Cancer Center | 40 | 2026-09-04 | 2026-09-11 |
| Exploring the Feasibility of Cerebrospinal Fluid (CSF) and Blood Plasma Liquid Biopsy in Patients With Metastatic Solid Tumours and Primary Central Nervous System (CNS) Tumours: A Pilot Study One time CSF and blood sample - Solid Tumor Malignancies, Brain Metastasases | Not applicable | Recruiting | Sunnybrook Health Sciences Centre | 60 | 2025-12-12 | 2026-07-31 |
| A Study to Assess the Safety and Tolerability of AZD1390 Given With Radiation Therapy in Patients With Brain Cancer Radiation Therapy, AZD1390 - Recurrent Glioblastoma Multiforme, Primary Glioblastoma Multiforme | Phase 1 | Completed | AstraZeneca | 159 | 2018-04-02 | 2026-10-15 |
Meningeal Neoplasms (3) · Brain Neoplasms (1) · Glioblastoma (1) · Hereditary Sensory and Autonomic Neuropathies (1) · Inhibition, Psychological (1)
Central Nervous System Neoplasms (3) · Neoplasms (3) · Neoplasms by Site (3) · Nervous System Diseases (3) · Nervous System Neoplasms (3) · Astrocytoma (1) · Behavior (1) · Brain Diseases (1) · Central Nervous System Diseases (1) · Congenital Abnormalities (1) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (1) · Genetic Diseases, Inborn (1) · Glioma (1) · Heredodegenerative Disorders, Nervous System (1) · Neoplasms by Histologic Type (1)
AZD1390 (1) · Blood Specimen Collection (1) · Radiotherapy (1)
AstraZeneca (1) · Memorial Sloan Kettering Cancer Center (1) · Sunnybrook Health Sciences Centre (1)
United States (2) · Canada (1) · Japan (1) · United Kingdom (1)
Anthony Chalmers (1) · Brandon Imber (1) · Deborah Forst (1) · Jan Drappatz (1) · Kazuhiko Mishima (1) · Louise Murray (1) · Mariza Daras (1) · Monica Chen, MD (1) · Patrick Wen (1) · Rajesh Jena (1) · Yoshiki Arakawa (1) · Yoshitaka Narita (1)
2017 (1)