7 recruiting, 2 unknown. 4 Phase 2, 1 Early Phase 1, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 4 | Recruiting 3, Unknown 1 |
| Early Phase 1 | 1 | Recruiting 1 |
| Phase 4 | 1 | Unknown 1 |
Follow Histiocytosis, Sinus: new trials by email Literature Review of Histiocytosis, Sinus trials Research Report on Histiocytosis, Sinus
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy and Safety of the RD Regimen(Lenalidomide, Dexamethasone) for Rosai-Dorfman Disease Lenalidomide, Dexamethasone - Rosai-Dorfman Disease | Phase 2 | Recruiting | Cancer Institute and Hospital, Chinese Academy of Medical Sciences | 40 | 2025-04-12 | 2025-09-22 |
| Mirdametinib in Histiocytic Disorders Mirdametinib - Langerhans Cell Histiocytosis (LCH), Juvenile Xanthogranuloma (JXG) | Phase 2 | Recruiting | Children's Hospital Medical Center, Cincinnati | 40 | 2024-02-05 | 2026-09-21 |
| Histiocytic Disorder Follow-up Study Histiocytosis, Langerhans Cell Histiocytosis | Recruiting | University of Alabama at Birmingham | 6000 | 2022-09-01 | 2026-06-12 | |
| In-Human CXCR4 Imaging of Hematologic and Solid Tumors Using [68Ga]-Pentixafor-PET [68Ga]-Pentixafor - Non-Hodgkin Lymphoma, Multiple Myeloma | Early Phase 1 | Recruiting | Memorial Sloan Kettering Cancer Center | 30 | 2021-10-01 | 2026-02-05 |
| Lenalidomide and Dexamethasone for Rosai-Dorfman Disease lenalidomide and dexamethasone - Rosai-Dorfman Disease | Phase 2 | Unknown | Peking Union Medical College Hospital | 16 | 2021-06-08 | 2021-06-16 |
| Cobimetinib in Refractory Langerhans Cell Histiocytosis (LCH), and Other Histiocytic Disorders Cobimetinib - Langerhan's Cell Histiocytosis, Juvenile Xanthogranuloma | Phase 2 | Recruiting | Carl Allen | 90 | 2021-04-19 | 2026-10-26 |
| Registry for Patients With Erdheim-Chester Disease and Other Histiocytoses Erdheim-Chester Disease | Recruiting | Memorial Sloan Kettering Cancer Center | 500 | 2017-10-26 | 2026-01-08 | |
| International Rare Histiocytic Disorders Registry (IRHDR) Registry study - Rare Histiocytic Disorders (RHDs), Erdheim-Chester Disease (ECD) | Recruiting | The Hospital for Sick Children | 400 | 2014-10-01 | 2025-06-24 | |
| Central China Rosai-Dorfman Disease Registry Mycophenolate mofetil combined with oral prednisone - Rosai-Dorfman Disease, Langerhans Cell Histiocytosis | Phase 4 | Unknown | Tongji Hospital | 20 | 2011-10-01 | 2022-03-17 |
Erdheim-Chester Disease (5) · Histiocytosis, Langerhans-Cell (5) · Histiocytic Sarcoma (2) · Xanthogranuloma, Juvenile (2) · Histiocytic Disorders, Malignant (1) · Histiocytosis (1) · Lymphoma, Non-Hodgkin (1) · Multiple Myeloma (1) · Necrobiotic Xanthogranuloma (1) · Neoplasms, Second Primary (1)
Hemic and Lymphatic Diseases (9) · Histiocytosis, Non-Langerhans-Cell (9) · Lymphatic Diseases (9) · Histiocytosis (8) · Lung Diseases (5) · Lung Diseases, Interstitial (5) · Respiratory Tract Diseases (5) · Neoplasms (3) · Neoplasms by Histologic Type (3) · Skin Diseases (3) · Skin and Connective Tissue Diseases (3) · Lymphoproliferative Disorders (2) · Blood Protein Disorders (1) · Cardiovascular Diseases (1) · Collagen Diseases (1)
Dexamethasone (2) · Lenalidomide (2) · 68Ga-pentixafor (1) · Prednisone (1) · cobimetinib (1) · mirdametinib (1)
Memorial Sloan Kettering Cancer Center (2) · Cancer Institute and Hospital, Chinese Academy of Medical Sciences (1) · Carl Allen (1) · Children's Hospital Medical Center, Cincinnati (1) · Peking Union Medical College Hospital (1) · The Hospital for Sick Children (1) · Tongji Hospital (1) · University of Alabama at Birmingham (1)
United States (6) · China (3) · Argentina (1) · Canada (1) · Czechia (1) · Germany (1) · Italy (1) · Netherlands (1) · Poland (1) · Spain (1)
Allison Bartlett, MD (1) · Anton Nosov, MD (1) · Ashish Kumar, MD, PhD (1) · Carl E Allen, MD, PhD (1) · Dao-bin Zhou (1) · Eli Diamond, MD (1) · Gaurav Goyal, MD (1) · Oussama Abla, MD (1) · Xinxin XX Cao, doctor (1)