4 completed, 4 unknown, 2 active not recruiting, 1 not yet recruiting. 2 Phase 1, 1 Not applicable, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 2 | Completed 1, Not yet recruiting 1 |
| Not applicable | 1 | Unknown 1 |
| Phase 2 | 1 | Unknown 1 |
Follow High-Grade Squamous Intraepithelial Lesions: new trials by email Literature Review of High-Grade Squamous Intraepithelial Lesions trials Research Report on High-Grade Squamous Intraepithelial Lesions
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Use of ACU-D1 in HPV Associated Vulvar and Perianal Lesions in People With HIV Dose Level 1 ACU-D1 ointment, Dose Level 2 ACU-D1 ointment, Dose Level 3 ACU-D1 ointment - Human Papilloma Virus, Human Immunodeficiency Virus | Phase 1 | Not yet recruiting | Emory University | 9 | 2026-12-01 | 2026-08-18 |
| Anal High-risk HPV, HSIL, and Microbiome Among Hispanic Peoples Living With HIV (PLWH) Biospecimen Collection, Questionnaires - Human Immunodeficiency Virus, Human Papillomavirus-Related Anal Squamous Cell Carcinoma | Active not recruiting | University of California, San Francisco | 217 | 2024-10-31 | 2026-08-20 | |
| Laser Ablation in the Treatment of High-grade Cervical Lesions laser ablation, LEEP or Conization - High-Grade Squamous Intraepithelial Lesions | Not applicable | Unknown | Peking Union Medical College Hospital | 308 | 2024-05-01 | 2024-03-27 |
| Association Between Surgical Timing and Route of Total Hysterectomy After LEEP and Perioperative Risk in Patients With Cervical HSIL surgical timing and operation path - High-Grade Squamous Intraepithelial Lesions | Completed | Sichuan Cancer Hospital and Research Institute | 826 | 2023-10-01 | 2024-03-22 | |
| Primary Cervical Cancer Screening by Self-sampling HPV Test Human Papillomavirus Infection, Cervical Cancer | Active not recruiting | Peking University People's Hospital | 17875 | 2022-11-19 | 2023-12-21 | |
| Clinical Evaluation of Detection of High Risk HPV in Urine Human Papillomavirus Infection, Cervical Cancer | Unknown | Peking University People's Hospital | 1000 | 2021-09-15 | 2022-01-27 | |
| Conservative Management in Patients Diagnosed With Grade 2 or Grade 3 CIN High-Grade Squamous Intraepithelial Lesions, Neoplasm Regression, Spontaneous | Unknown | Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau | 104 | 2019-10-14 | 2019-10-04 | |
| Preventing Invasive Cervical Cancer: The Importance of Expectant Management in Young Women With High-grade Pre-cancerous Lesions Data extraction from medical files, Immunohistochemistry - High-Grade Squamous Intraepithelial Lesions | Completed | Catherine Vanpachterbeke | 100 | 2019-03-01 | 2022-07-20 | |
| Evaluation of Thioldisulfide Balance in Cervical Preinvasive Lesions Disulphide(μmol/L), Total Oxidant Capacity(μmolH2O2Equiv/L) - Oxidative Stress, Low Grade Squamous Intraepithelial Lesion | Completed | Muğla Sıtkı Koçman University | 300 | 2018-09-20 | 2020-02-06 | |
| Study of Topical ABI-1968 in Subjects With Precancerous Cervical Lesions From Human Papillomavirus (HPV) Infection ABI-1968 - HSIL, HSIL of Cervix | Phase 1 | Completed | Antiva Biosciences | 16 | 2018-01-01 | 2019-07-10 |
| Safety and Efficacy Study of TVGV-1 Vaccine to Treat HPV Induced Cervical HSIL TVGV-1, GPI-0100, Placebo - Human Papillomavirus, High-Grade Squamous Intraepithelial Lesions | Phase 2 | Unknown | THEVAX Genetics Vaccine | 10 | 2015-11-01 | 2017-10-25 |
Squamous Intraepithelial Lesions (11) · Uterine Cervical Dysplasia (4) · Papillomavirus Infections (3) · Uterine Cervical Neoplasms (3) · Acquired Immunodeficiency Syndrome (2) · Adenocarcinoma in Situ (2) · Atypical Squamous Cells of the Cervix (2) · Disease Progression (1) · Neoplasm Regression, Spontaneous (1) · Neoplasms (1)
Morphological and Microscopic Findings (11) · Pathological Conditions, Signs and Symptoms (11) · Genital Diseases (7) · Urogenital Diseases (7) · Communicable Diseases (5) · Infections (5) · Sexually Transmitted Diseases (5) · Sexually Transmitted Diseases, Viral (5) · Virus Diseases (5) · Female Urogenital Diseases (4) · Female Urogenital Diseases and Pregnancy Complications (4) · Genital Diseases, Female (4) · Neoplasms (4) · Precancerous Conditions (4) · Uterine Cervical Diseases (4)
Adjuvants, Pharmaceutic (1) · Antigens (1) · Conization (1) · GPI0100 (1) · Immunohistochemistry (1) · Laser Therapy (1) · Specimen Handling (1) · Surveys and Questionnaires (1)
Peking University People's Hospital (2) · Antiva Biosciences (1) · Catherine Vanpachterbeke (1) · Emory University (1) · Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau (1) · Muğla Sıtkı Koçman University (1) · Peking Union Medical College Hospital (1) · Sichuan Cancer Hospital and Research Institute (1) · THEVAX Genetics Vaccine (1) · University of California, San Francisco (1)
United States (4) · China (3) · Australia (1) · Belgium (1) · Mexico (1) · Puerto Rico (1) · Spain (1) · Turkey (Türkiye) (1)
Dengfeng Wang, Ph.D (1) · Frank L Douglas, PhD, MD (1) · Georges Salem Wehbe, MD (1) · Joel Palefsky, MD (1) · Lan Zhu, MD (1) · Lisa Flowers, MD, MPH (1)
PMID 24118526, PMID 24458427, PMID 27526956, PMID 33394202, PMID 35689493
U54CA242646 (1)