4 completed, 1 recruiting, 1 terminated. 2 Phase 2, 2 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 2 | Completed 2 |
| Phase 3 | 2 | Completed 1, Terminated 1 |
Follow Gorlin Syndrome: new trials by email Literature Review of Gorlin Syndrome trials Research Report on Gorlin Syndrome
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy and Safety of Patidegib Gel 2% for Preventing Basal Cell Carcinomas on the Face of Adults With Gorlin Syndrome Patidegib Topical Gel, Patidegib Topical Gel with no active patidegib - Gorlin Syndrome | Phase 3 | Completed | Sol-Gel Technologies, Ltd. | 113 | 2024-03-17 | 2026-09-18 |
| Nevoid Basal Cell Carcinomas in Gorlin Syndrome Active surveillance - Basal Cell Carcinoma, Gorlin Syndrome | Completed | Oslo University Hospital | 7 | 2023-06-01 | 2026-10-09 | |
| Oral Hedgehog Inhibitors in the Treatment of Basal Cell Carcinoma in the Netherlands: a Prospective Registration Study Vismodegib, Sonidegib - Basal Cell Carcinoma, Locally Advanced Basal Cell Carcinoma | Recruiting | Maastricht University Medical Center | 80 | 2021-11-01 | 2025-04-04 | |
| Efficacy, Safety and Pharmacokinetics of Oral LDE225 in Treatment of Patients With Nevoid Basal Cell Carcinoma Syndrome (NBCCS) LDE225, Placebo - Basal Cell Carcinoma, Gorlin Syndrome | Phase 2 | Completed | Novartis Pharmaceuticals | 10 | 2011-04-01 | 2015-10-19 |
| To Determine The Efficacy and Safety of GDC-0449 in Patients With Basal Cell Nevus Syndrome (BCNS) GDC-0449 - Basal Cell Nevus Syndrome, Gorlin Syndrome | Phase 2 | Completed | UCSF Benioff Children's Hospital Oakland | 41 | 2009-08-01 | 2021-01-11 |
| Two Studies to Determine if Verteporfin PDT is Effective & Safe in Treating Multiple Basal Cell Carcinoma of the Skin. verteporfin PDT - Basal Cell Carcinoma, Nevoid Basal Cell Carcinoma Syndrome | Phase 3 | Terminated | QLT Inc. | 2011-03-16 |
Basal Cell Nevus Syndrome (6) · Carcinoma, Basal Cell (4) · Basal cell carcinoma, multiple (1) · Carcinoma (1) · Neoplasms, Basal Cell (1) · Skin Neoplasms (1)
Abnormalities, Multiple (6) · Bone Cysts (6) · Bone Diseases (6) · Bone Diseases, Developmental (6) · Congenital Abnormalities (6) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (6) · Cysts (6) · Genetic Diseases, Inborn (6) · Jaw Cysts (6) · Jaw Diseases (6) · Musculoskeletal Diseases (6) · Neoplasms (6) · Neoplasms by Histologic Type (6) · Neoplasms, Glandular and Epithelial (6) · Neoplastic Syndromes, Hereditary (6)
HhAntag691 (2) · sonidegib (2) · IPI-926 (1) · Watchful Waiting (1)
Maastricht University Medical Center (1) · Novartis Pharmaceuticals (1) · Oslo University Hospital (1) · QLT Inc. (1) · Sol-Gel Technologies, Ltd. (1) · UCSF Benioff Children's Hospital Oakland (1)
Germany (2) · Netherlands (2) · United States (2) · Austria (1) · Belgium (1) · Canada (1) · France (1) · Italy (1) · Norway (1) · Spain (1) · United Kingdom (1)
Ervin Epstein, MD (1) · Herma Neyndorff (1) · K Mosterd, MD, PhD (1) · Kristin Hortemo, MD, PhD (1)
PMID 22670904, PMID 24623282, PMID 27838224
2023 (1)