7 unknown, 6 completed, 3 recruiting, 2 not yet recruiting. 9 Not applicable, 4 Phase 4, 2 Phase 2, 1 Early Phase 1, 1 Phase 1.
Follow Gingival Pigmentation: new trials by email Literature Review of Gingival Pigmentation trials Research Report on Gingival Pigmentation
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Evaluation of the Efficacy of Topical Application of Liquid Nitrogen and Ascorbic Acid in Treatment of Gingival Pigmentation Topical application of ascorbic acid for treatment of gingival pigmentation, Topical application of liquid nitrogen for treatment of gingival pigmentation, Treatment of gingival pigmentation by surgical technique - Gingival Pigmentation, Gingiival Hyperpigmentation | Phase 3 | Enrolling by invitation | Al-Azhar University | 30 | 2026-09-01 | 2026-09-09 |
| Influence of Adjunctive Acids Use on Esthetic Outcomes of Gingival Melanin Depigmentation: A Periodontal-Operative Pilot Randomized Clinical Trial Citric acid - Gingival Pigmentation | Not applicable | Not yet recruiting | Dijlah University | 30 | 2026-08-01 | 2026-07-16 |
| Clinical Evaluation of Microneedling Technique With Topical Application of Silymarin on Gingival Hyperpigmentation in Comparison With Diode Laser and Scalpel Methods. Gingival Depigmentation with Conventional Method, Gingival Depigmentation with Diode Laser, Gingival Depigmentation with Microneedling and Silymarin Application - Gingival Pigmentation, Gingival Hyperpigmentaion | Not applicable | Recruiting | Fayoum University | 30 | 2026-07-01 | 2026-02-13 |
| Reducing Gingival Pigmentation Through Workplace Mitigation in Restaurant Oven Workers Workplace Heat and Air Pollution Mitigation Package, Delayed Workplace Heat and Air Pollution Mitigation Package - Gingival Pigmentation, Occupational Heat Exposure | Phase 4 | Completed | Salah M. Ibrahim | 200 | 2026-01-01 | 2026-09-04 |
| Microneedling With Platelet Rich Plasma Versus Microneedling Alone For Gingival Depigmentation Microneedling will be done with application of Platelet Rich Plasma for depigmentation., Microneedling alone for Gingival Depigmentation. - Gingival Pigmentation | Not applicable | Recruiting | Cairo University | 32 | 2025-10-01 | 2026-01-22 |
| Gingival Hyperpigmentation Treatment Vitamin c and glutathione, Surgical depigmentation - Gingival Pigmentation, Depigmentation | Phase 2 | Recruiting | Cairo University | 30 | 2025-08-01 | 2026-05-19 |
| Efficacy of Microneedling With Vitamin C in Performing Gingival Depigmentation Vitamin C, Microneedling, Diode laser - Gingival Pigmentation | Phase 1 / Phase 2 | Not yet recruiting | Fayoum University | 30 | 2025-07-01 | 2025-07-17 |
| Nano Silver Effect in Rapid Wound Healing Nano Silver Dressing, Non eugenol zinc oxide Dressing - Gingival Pigmentation | Not applicable | Completed | Damascus University | 12 | 2024-06-02 | 2026-04-09 |
| The Adjunctive Role of Vitamin C on Pigment Recurrence (Randomized Clinical and Histological Trial) Injectable applied vitamin C, Topical applied Vitamin C, Surgical depigmentation only - Gingival Pigmentation | Phase 4 | Unknown | Ain Shams University | 24 | 2023-08-01 | 2024-03-15 |
| Comparative Evaluation of Microsurgery vs Diode Laser Technique of Gingival Depigmentation Gingival depigmentation using microsurgery, Gingival Depigmentation using Diode Laser - Gingival Pigmentation, Melanosis | Not applicable | Unknown | Postgraduate Institute of Dental Sciences Rohtak | 22 | 2023-07-01 | 2023-07-05 |
| Comparative Evaluation of Microsurgery vs Conventional Surgical Technique of Gingival Depigmentation Gingival depigmentation using microsurgery, Conventional surgical depigmentation - Gingival Pigmentation, Melanosis | Not applicable | Unknown | Postgraduate Institute of Dental Sciences Rohtak | 22 | 2023-07-01 | 2023-07-05 |
| Microneedling With Vitamin C Versus Injectable Vitamin C for Depigmentation in Gingival Melanin Hyperpigmentation Microneedling will be done with application of topical vitamin C paste for depigmentation, Vitamin C injection - Gingival Pigmentation | Not applicable | Unknown | Cairo University | 22 | 2023-04-01 | 2023-03-28 |
| Effect of Oxidant Gel and Anti-oxidant Gel on Wound Healing After Gingival Depigmentation blue®m Gel, NBF GINGIVAL GEL®, COE-PAK™ - Gingival Pigmentation | Phase 4 | Unknown | Cairo University | 30 | 2023-02-28 | 2023-05-01 |
| Vitamin C Mesotherapy Versus Diode Laser for the Management of Physiologic Gingival Pigmentation Vitamin C mesotherapy, Diode laser - Gingival Pigmentation | Not applicable | Completed | Hams Hamed Abdelrahman | 26 | 2022-10-22 | 2023-04-27 |
| The Prevalence of Gingival Pigmentation Among a Sample of Adult Egyptian Population. Gingival Pigmentation | Completed | Cairo University | 374 | 2022-10-01 | 2024-07-03 | |
| Gingival Depigmentation Using Diode Laser 940nm Versus 980nm Biolase Epic X 940nm wavelength Diode laser, Doctor smile simpler 980nm wavelength Diode laser - Gingival Pigmentation | Not applicable | Completed | Nourhan M.Aly | 20 | 2021-10-01 | 2023-12-12 |
| Effect of Injectable Platelet Rich Fibrin on Healing and Patient Satisfaction Following Laser Gingival Depigmentation i-PRF, Diode Laser - Gingival Pigmentation | Phase 4 | Completed | Ain Shams University | 8 | 2020-02-20 | 2022-03-17 |
| Effect of Non-eugenol Periodontal Pack With and Without PRF on Post-operative Pain and Wound Healing After Gingival Depigmentation PRF under non-eugenol containing periodontal pack, Non-eugenol containing periodontal pack - Gingival Pigmentation | Early Phase 1 | Unknown | Cairo University | 24 | 2020-01-01 | 2020-07-31 |
| The Association of Blood Haemoglobin and Colour of Gums Blood Haemoglobin - Gingival Pigmentation, Gingivitis | Unknown | KLE Society's Institute of Dental Sciences | 60 | 2019-12-20 | 2019-12-17 |
Vitiligo (3) · Melanosis (2) · Gingivitis (1) · Periodontitis (1)
Pigmentation Disorders (5) · Skin Diseases (5) · Skin and Connective Tissue Diseases (5) · Hypopigmentation (3) · Hyperpigmentation (2) · Gingival Diseases (1) · Infections (1) · Mouth Diseases (1) · Periodontal Diseases (1) · Stomatognathic Diseases (1)
Lasers, Semiconductor (4) · Ascorbic Acid (3) · Percutaneous Collagen Induction (3) · Citric Acid (1) · Coe-Pak (1) · Glutathione (1)
Cairo University (6) · Ain Shams University (2) · Fayoum University (2) · Postgraduate Institute of Dental Sciences Rohtak (2) · Al-Azhar University (1) · Damascus University (1) · Dijlah University (1) · Hams Hamed Abdelrahman (1) · KLE Society's Institute of Dental Sciences (1) · Nourhan M.Aly (1) · Salah M. Ibrahim (1)
Egypt (11) · India (2) · Iraq (1) · Syria (1)
Ara V Seferian, DDS (1) · Gillan I El-Kimary, PhD (1) · Hala K. Abd-El-Gaber, Professor (1) · Ibrahim Hammad Ibrahim, assistant professor (1) · Mona Darhous, PHD (1) · Nayroz Mohammed Tarrad, Professor (1) · Nourhan A Abdullah, Phd (1) · Nourhan M Aly, MSc (1) · Ola Ezzatt (1) · Rehab Ahmed Osman, Lecturer (1) · Sara Esmat, BDS (1) · Souzy K Anwar, PhD (1) · Tarek A Qasim, DDS MSc PhD (1)
PMID 23493062, PMID 36974245, PMID 37990224, PMID 38536994, PMID 38752063, PMID 5948222