4 completed, 3 unknown, 1 recruiting. 2 Phase 2, 1 Not applicable, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 2 | Completed 1, Unknown 1 |
| Not applicable | 1 | Unknown 1 |
| Phase 1 | 1 | Unknown 1 |
Follow GBA Gene Mutation: new trials by email Literature Review of GBA Gene Mutation trials Research Report on GBA Gene Mutation
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| High-Dose Ambroxol in GBA1-Related Parkinson Ambroxol Hydrochloride - Parkinson Disease, GBA Gene Mutation | Phase 1 / Phase 2 | Unknown | Agyany Pharma LTD | 40 | 2023-10-24 | 2024-02-08 |
| Drug Discovery for Parkinson's With Mutations in the GBA Gene Biological Sample Collection - Parkinson Disease, Gaucher Disease | Unknown | New York Stem Cell Foundation Research Institute | 60 | 2022-07-15 | 2025-03-03 | |
| Ambroxol as a Disease-modifying Treatment in GBA-PD Ambroxol Hydrochloride, Placebo - Parkinson Disease, GBA Gene Mutation | Phase 2 | Completed | Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta | 65 | 2022-03-09 | 2025-08-14 |
| Evaluation of the Frequency and Severity of Sleep Abnormalities in Patients With Parkinson's Disease Xtrodes home PSG system - Parkinson Disease, GBA Gene Mutation | Not applicable | Unknown | Tel-Aviv Sourasky Medical Center | 240 | 2020-06-01 | 2023-03-10 |
| World Data on Ambroxol for Patients With GD and GBA Related PD Gaucher Disease, Parkinson Disease | Recruiting | Shaare Zedek Medical Center | 300 | 2020-05-06 | 2026-04-29 | |
| The GBA Multimodal Study in Parkinson's Disease PET scan, neuroQWERTY - Parkinson Disease, GBA Gene Mutation | Completed | Pacific Parkinson's Research Centre | 30 | 2019-05-01 | 2026-09-02 | |
| LRRK2, GBA and Other Genetic Biomarkers in Eastern European (Ashkenazi) Jews With and Without Parkinson's Disease Parkinson Disease, LRRK2 | Completed | Icahn School of Medicine at Mount Sinai | 203 | 2019-04-01 | 2025-04-16 | |
| Parkinson Disease and DBS: Cognitive Effects in GBA Mutation Carriers Parkinson, Parkinson Disease | Completed | Rutgers, The State University of New Jersey | 150 | 2017-07-01 | 2026-07-29 |
Parkinson Disease (8) · Gaucher Disease (3) · Parkinsonian Disorders (2) · Cognitive Dysfunction (1) · Genetic Predisposition to Disease (1) · Movement Disorders (1) · Neurodegenerative Diseases (1)
Basal Ganglia Diseases (8) · Brain Diseases (8) · Central Nervous System Diseases (8) · Nervous System Diseases (8) · Synucleinopathies (8) · Movement Disorders (7) · Neurodegenerative Diseases (7) · Parkinsonian Disorders (6) · Brain Diseases, Metabolic (3) · Brain Diseases, Metabolic, Inborn (3) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (3) · Genetic Diseases, Inborn (3) · Lipid Metabolism Disorders (3) · Lipid Metabolism, Inborn Errors (3) · Lipidoses (3)
Ambroxol (1) · Positron-Emission Tomography (1)
Agyany Pharma LTD (1) · Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta (1) · Icahn School of Medicine at Mount Sinai (1) · New York Stem Cell Foundation Research Institute (1) · Pacific Parkinson's Research Centre (1) · Rutgers, The State University of New Jersey (1) · Shaare Zedek Medical Center (1) · Tel-Aviv Sourasky Medical Center (1)
United States (4) · Israel (3) · Canada (1) · Italy (1)
Ari Zimran, MD (2) · A. Jon Stoessl, CM, MD, FRCPC, FCAHS (1) · Anat Mirelman, PhD (1) · Gian Pal (1) · Laura Andres-Martin (1) · Laurie Ozelius, PhD (1) · Michele Matarazzo, MD (1) · Rachel Saunders-Pullman, MD, MPH (1) · Roberto Cilia (1)
K23NS097625 (1), U01NS107016 (1)