5 completed, 3 recruiting, 1 terminated. 1 Phase 3, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 1 | Completed 1 |
| Phase 4 | 1 | Recruiting 1 |
Follow Factor VIII Deficiency: new trials by email Literature Review of Factor VIII Deficiency trials Research Report on Factor VIII Deficiency
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efanesoctocog Alfa Prophylaxis in Patients With Hemophilia A With Synovial Hypertrophy Efanesoctocog alfa - Factor VIII Deficiency | Phase 4 | Recruiting | Sanofi | 35 | 2025-09-23 | 2026-10-15 |
| Genetic Factors of the Desmopressin Response in Carriers of Hemophilia A Desmopressin - Carrier of Hemophilia A, Desmopressin | Completed | Groupe Maladies hémorragiques de Bretagne | 361 | 2022-01-01 | 2023-08-31 | |
| ATHN Transcends: A Natural History Study of Non-Neoplastic Hematologic Disorders Hematologic Disorder, Bleeding Disorder | Recruiting | American Thrombosis and Hemostasis Network | 3000 | 2020-09-30 | 2026-08-17 | |
| A Phase 3 Open-label Interventional Study of Intravenous Recombinant Coagulation Factor VIII Fc-von Willebrand Factor-XTEN Fusion Protein, Efanesoctocog Alfa (BIVV001), in Patients With Severe Hemophilia A efanesoctocog alfa (BIVV001) - Factor VIII Deficiency | Phase 3 | Completed | Bioverativ, a Sanofi company | 159 | 2019-11-19 | 2025-09-17 |
| Lead-in Study to Collect Prospective Efficacy and Safety Data of Current FVIII Prophylaxis Replacement Therapy in Adult Hemophilia A Participants Standard of Care FVIII Replacement therapy - Blood Coagulation Disorder, Blood Coagulation Disorders, Inherited | Completed | Spark Therapeutics, Inc. | 25 | 2019-01-21 | 2023-07-10 | |
| Pharmacokinetic Characterization of the Hemophilia A Population in Spain Using myPKFiT® octocog alfa, rurioctocog alfa pegol - Hemophilia A, Hemophilia | Completed | Spanish Society of Thrombosis and Haemostasis | 50 | 2016-11-11 | 2023-06-08 | |
| A Study Comparing Factor Level and Inhibitor Titer Testing Results Drawn From Central Venous Lines and Venipuncture Peripheral Vein Blood draw - Hemophilia A, Factor VIII Deficiency | Terminated | Children's Mercy Hospital Kansas City | 3 | 2014-11-01 | 2021-01-06 | |
| The European Paediatric Network for Haemophilia Management ( PedNet Registry) Factor VIII Deficiency, Factor IX Deficiency | Recruiting | PedNet Haemophilia Research Foundation | 4000 | 2014-06-01 | 2025-09-16 | |
| An Institutional Pilot Study to Investigate Physical Activity Patterns in Boys With Hemophilia Accelerometer - Hemophilia A, Hemophilia B | Completed | The Hospital for Sick Children | 66 | 2013-09-01 | 2016-12-14 |
Hemophilia A (9) · Hemophilia B (4) · Hematologic Diseases (2) · Anemia, Sickle Cell (1) · Blood Coagulation Disorders (1) · Blood Coagulation Disorders, Inherited (1) · Blood Platelet Disorders (1) · Coagulation Protein Disorders (1) · Connective Tissue Diseases (1) · Genetic Diseases, Inborn (1) · Genetic Diseases, X-Linked (1) · Hemarthrosis (1) · Hemorrhagic Disorders (1) · Hemostatic Disorders (1) · Motor Activity (1)
Congenital, Hereditary, and Neonatal Diseases and Abnormalities (9) · Hemic and Lymphatic Diseases (9) · Blood Coagulation Disorders (8) · Blood Coagulation Disorders, Inherited (8) · Coagulation Protein Disorders (8) · Genetic Diseases, Inborn (8) · Hemorrhagic Disorders (8) · Hematologic Diseases (7) · Genetic Diseases, X-Linked (4) · Pathological Conditions, Signs and Symptoms (2) · Anemia (1) · Anemia, Hemolytic (1) · Anemia, Hemolytic, Congenital (1) · Behavior (1) · Body Weight (1)
BIVV001 (2) · BAX 855 (1) · Deamino Arginine Vasopressin (1) · F8 protein, human (1) · Factor VIII (1)
American Thrombosis and Hemostasis Network (1) · Bioverativ, a Sanofi company (1) · Children's Mercy Hospital Kansas City (1) · Groupe Maladies hémorragiques de Bretagne (1) · PedNet Haemophilia Research Foundation (1) · Sanofi (1) · Spanish Society of Thrombosis and Haemostasis (1) · Spark Therapeutics, Inc. (1) · The Hospital for Sick Children (1)
Canada (5) · United States (5) · France (3) · Spain (3) · Australia (2) · Belgium (2) · Germany (2) · Greece (2) · Italy (2) · Japan (2) · Netherlands (2) · Taiwan (2) · United Kingdom (2) · Argentina (1) · Austria (1)
Christoph Male, MD (1) · Gili Kenet, PhD, MD (1) · Michael Recht, MD, PhD, MBA (1) · Tammuella Chrisentery-Singleton, MD (1) · Vanessa Bouskill, NP, MN (1)
PMID 23323899, PMID 23482934, PMID 23553768, PMID 23574131, PMID 24784937, PMID 24893572, PMID 26856685, PMID 28544163, PMID 28699675, PMID 29212115, PMID 29243367, PMID 30792204, PMID 31186271, PMID 31919092, PMID 32519345, PMID 32572865, PMID 32627880, PMID 32935414, PMID 33683753, PMID 33745218, PMID 35925557, PMID 36571801, PMID 36696215, PMID 36720133, PMID 36798899, PMID 37647211, PMID 37881836, PMID 38214949, PMID 38578720, PMID 38866249, PMID 39414418, PMID 39576432, PMID 39576433, PMID 39605212, PMID 39927501, PMID 40099428, PMID 40120320, PMID 40123267, PMID 40444652, PMID 40706963, PMID 41583536, PMID 41789959, PMID 42598540
2019 (1)