313 completed, 203 recruiting, 135 unknown, 66 terminated. 260 Phase 2, 200 Not applicable, 176 Phase 1, 57 Phase 3, 18 Early Phase 1.
Follow Endometrial Cancer: new trials by email Literature Review of Endometrial Cancer trials Research Report on Endometrial Cancer
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Semaglutide, Weight Loss, and LNG-IUD for Conservative Treatment of Endometrial Atypical Hyperplasia and Grade 1 Endometrial Cancer Semaglutide (Wegovy) weekly injection, LNG-IUD (Progestin), Structured Weight Loss Program - Endometrial Atypical Hyperplasia, Endometrial Atypical Hyperplasia/Endometrioid Intraepithelial Neoplasia | Phase 2 | Not yet recruiting | The Methodist Hospital Research Institute | 48 | 2027-01-01 | 2026-10-01 |
| Tirzepatide in Women With Obesity and Endometrial Intra-epithelial Neoplasia or Grade 1 Endometrial Cancer Tirzepatide - Endometrial Cancer, Endometrial Intraepithelial Neoplasia | Phase 2 | Not yet recruiting | UNC Lineberger Comprehensive Cancer Center | 40 | 2027-01-01 | 2026-09-28 |
| Effect of Weight Management on AMPK Activation in the Adjunctive Treatment of Endometrial Cancer DEAR-Based Comprehensive Weight Management, Balanced Diet and Self-Directed Exercise - Endometrial Cancer | Not applicable | Not yet recruiting | Peking University People's Hospital | 160 | 2027-01-01 | 2026-10-16 |
| Development Of An Endometrial Cancer Educational Tool Interactive Educational Website - Endometrial Cancer | Not applicable | Not yet recruiting | M.D. Anderson Cancer Center | 250 | 2027-01-01 | 2026-07-31 |
| SHAPE-ENDO: Pilot Randomized Trial of Multimodal Pre-Surgical Optimization Versus Standard Surgery in Patients With Obesity and Early-Stage Endometrial Cancer GLP-1 Receptor Agonist, Levonorgestrel IUD (Lng-IUD), Oral Progestins - Endometrial Cancer, Endometrial Cancer Stage I | Phase 4 | Not yet recruiting | Hospital Universitari de Bellvitge | 80 | 2027-01-01 | 2026-06-10 |
| A Study of LG00313112 in Participants With Advanced Solid Malignancies Harboring a TP53 Y220C Mutation LG00313112 - Ovarian Cancer, Small Cell Lung Cancer | Phase 1 / Phase 2 | Not yet recruiting | LG Chem | 250 | 2026-12-01 | 2026-08-07 |
| Imlunestrant/Abemaciclib/Selinexor in Ovarian and Endometrial Imlunestrant, Abemaciclib, Selinexor - Low Grade Ovarian Serous Adenocarcinoma, Endometrial Cancer | Phase 2 | Not yet recruiting | Dana-Farber Cancer Institute | 60 | 2026-12-01 | 2026-09-21 |
| MTX-531-001 Phase 1 Study in Advanced Solid Tumors MTX-531 - Solid Tumors (Phase 1), HNSCC | Phase 1 | Not yet recruiting | MEKanistic Therapeutics, Inc. | 71 | 2026-10-20 | 2026-10-15 |
| Symbiotic-GYN-18: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Advanced or Recurrent MMR-proficient Endometrial Cancer PF-08634404, Pembrolizumab, Standard of Care Chemotherapy - Endometrial Neoplasms, Endometrial Cancer | Phase 3 | Not yet recruiting | Pfizer | 600 | 2026-10-09 | 2026-10-08 |
| Radiotherapy for Gynecologic Cancer With Up to 10 Active Metastatic Lesions Routine-care metastasis-directed radiotherapy - Cervical Cancer, Gynecologic Cancer | Recruiting | Affidea Nu-med Center of Oncological DIagnostics and Therapy | 500 | 2026-10-06 | 2026-10-20 | |
| Signatera Assessment in Early-Stage Endometrial Cancer Signatera Genome ultra-sensitive ctDNA blood test - Endometrial Cancer | Not applicable | Not yet recruiting | Natera, Inc. | 1010 | 2026-10-01 | 2026-06-17 |
| Gut Microbiome in Patients With Lung and Melanoma Cancer and Intestinal Microbiota in Gynecologic Cancers sample collection - Non Small Cell Lung Cancer, Melanoma (Skin Cancer) | Not applicable | Not yet recruiting | European Institute of Oncology | 360 | 2026-10-01 | 2026-09-11 |
| Stellate Ganglion Block and Dexmedetomidine for Postoperative Sleep in Women Undergoing Laparoscopic Gynecologic Surgery DEX 0.2 μg/kg/h., SGB, 0.9% Sodium Chloride (Placebo) - Uterine Fibroids (Leiomyoma), Adenomyosis of Uterus | Not applicable | Recruiting | Catherin Zhang | 100 | 2026-10-01 | 2026-10-06 |
| Assessing Survival Outcomes With Checkpoint Inhibition ExteNded vs Discontinued in Endometrial Cancer anti-PD1 agent therapy - 1 year, anti-PD1 agent therapy - 2 years - Endometrial Adenocarcinoma, Metastatic Endometrial Cancer | Phase 3 | Not yet recruiting | UNC Lineberger Comprehensive Cancer Center | 140 | 2026-10-01 | 2026-10-15 |
| 27-Inch Versus 55-Inch Monitors in Women Undergoing Endometrial Cancer Surgery 27-Inch Endoscopic Imaging Monitor, 55-Inch Endoscopic Imaging Monitor - Endometrial Cancer | Not applicable | Not yet recruiting | Metehan Uzundal | 70 | 2026-10-01 | 2026-10-20 |
| TR115 in ARID1A-Mutated Advanced Solid Tumors TR115 - Ovarian Clear Cell Carcinoma, Endometrial Cancer | Phase 2 | Not yet recruiting | Tarapeutics Science Inc. | 50 | 2026-09-20 | 2026-08-28 |
| Weight-loss Drug for Fertility-Sparing Treatment of Atypical Hyperplasia and Low-grade Cancer of the Endometrium Wegovy, Mirena - Endometrial Cancer, Atypical Hyperplasia | Phase 2 | Recruiting | GynOncTrials | 71 | 2026-09-17 | 2026-10-05 |
| PEG-rhG-CSF Primary Prophylaxis vs Therapeutic Short-Acting rhG-CSF for Neutropenia During Pelvic Chemoradiotherapy in Cervical or Endometrial Cancer Pegylated Recombinant Human Granulocyte Colony-Stimulating Factor (PEG-rhG-CSF), Recombinant Human Granulocyte Colony-Stimulating Factor (rhG-CSF) - Cervical Cancer, Endometrial Cancer | Not applicable | Active not recruiting | The Second Hospital of Anhui Medical University | 90 | 2026-09-15 | 2026-10-08 |
| Phase 1 Study of STRO-006 in Adults With Refractory Solid Tumors That Are Recurrent or Metastatic STRO-006, Pembrolizumab - Head & Neck Squamous Cell Carcinoma, Non-Small Cell Lung Cancer | Phase 1 | Not yet recruiting | Sutro Biopharma, Inc. | 285 | 2026-09-14 | 2026-09-08 |
| A Phase 1, First-in-Human (FIH), Open-Label, Dose-Escalation and Dose Expansion Study of the Peptide Drug Conjugate (PDC), TS-104, as a Monotherapy in Subjects With Select Advanced Solid Tumors TS-104 - NSCLC (Non-small Cell Lung Cancer), HNSCC | Phase 1 | Recruiting | TwoStep Therapeutics, Inc. | 74 | 2026-09-02 | 2026-09-30 |
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Endometrial Neoplasms (865) · Ovarian Neoplasms (252) · Uterine Cervical Neoplasms (185) · Breast Neoplasms (122) · Colorectal Neoplasms (64) · Neoplasms (64) · Carcinoma, Non-Small-Cell Lung (58) · Fallopian Tube Neoplasms (56) · Stomach Neoplasms (56) · Prostatic Neoplasms (50) · Uterine Neoplasms (49) · Pancreatic Neoplasms (47) · Sarcoma (45) · Lung Neoplasms (44) · Esophageal Neoplasms (41)
Female Urogenital Diseases (865) · Female Urogenital Diseases and Pregnancy Complications (865) · Urogenital Diseases (865) · Genital Diseases (863) · Urogenital Neoplasms (862) · Genital Diseases, Female (860) · Neoplasms by Site (860) · Uterine Diseases (858) · Genital Neoplasms, Female (854) · Uterine Neoplasms (816) · Neoplasms (801) · Endocrine System Diseases (281) · Endocrine Gland Neoplasms (274) · Gonadal Disorders (268) · Adnexal Diseases (267)
Paclitaxel (54) · Carboplatin (47) · pembrolizumab (39) · Cisplatin (24) · Bevacizumab (15) · Doxorubicin (15) · Surveys and Questionnaires (15) · Radiotherapy (14) · Docetaxel (13) · Letrozole (13) · Blood Specimen Collection (12) · Megestrol Acetate (10) · Metformin (10) · Hysterectomy (9) · abemaciclib (9)
Memorial Sloan Kettering Cancer Center (25) · M.D. Anderson Cancer Center (22) · Gynecologic Oncology Group (18) · National Cancer Institute (NCI) (15) · AstraZeneca (13) · Fondazione Policlinico Universitario Agostino Gemelli IRCCS (13) · UNC Lineberger Comprehensive Cancer Center (13) · European Organisation for Research and Treatment of Cancer - EORTC (9) · University of Oklahoma (9) · Dana-Farber Cancer Institute (8) · Imperial College London (8) · Peking University People's Hospital (7) · Washington University School of Medicine (7) · Asan Medical Center (6) · Assiut University (6)
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Lei Li, M.D. (5) · Kathleen Moore, MD (4) · Pamela Soliman, MD (4) · Panagiotis Konstantinopoulos, MD, PhD (4) · Vicky Makker, MD (4) · Clare Shaw, Phd (3) · David M Kushner, MD (3) · David S. Miller, MD (3) · Emma Barber, MD, MS (3) · Joo-Hyun Nam, M.D., Ph.D. (3) · Levi S. Downs, MD (3) · Nicolas Wentzensen, M.D. (3)
PMID 36971688, PMID 40966692, PMID 35420695, PMID 15169803, PMID 21173649, PMID 23636398, PMID 26552419, PMID 27325856, PMID 11704843, PMID 11705489, PMID 11875733, PMID 12528778, PMID 12648575, PMID 12798713, PMID 12800205, PMID 12914829, PMID 12957454, PMID 14615449, PMID 15010069, PMID 15122083, PMID 15177491, PMID 15304161, PMID 15551359, PMID 15592836, PMID 15659504, PMID 15721401, PMID 15721421, PMID 15805295, PMID 15975638, PMID 15978659, PMID 16084259, PMID 16330675, PMID 16400639, PMID 16446331, PMID 16528479, PMID 16712905, PMID 16775581, PMID 17033909, PMID 17182091, PMID 17251932, PMID 17251933, PMID 17362317, PMID 17466514, PMID 17486128, PMID 17910981, PMID 17945336, PMID 18323549, PMID 18378136, PMID 18446090, PMID 18469262
2023 (13), P30CA043703 (6), 2016 (5), 2017 (3), P30CA014520 (3), 2019 (2), 2025 (2), P30CA008748 (2), P30CA012197 (2), P50CA265793 (2), U10CA032102 (2), 1UG3CA297705-01A1 (1), 2008 (1), 2009 (1), 2015 (1)