4 completed, 1 terminated. 5 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 5 | Completed 4, Terminated 1 |
Follow digital ulcers: new trials by email Literature Review of digital ulcers trials Research Report on digital ulcers
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Macitentan for the Treatment of Digital Ulcers in Systemic Sclerosis Patients Macitentan 3 mg, Macitentan 10 mg, Placebo - Digital Ulcers | Phase 3 | Terminated | Actelion | 265 | 2011-12-01 | 2025-02-04 |
| Macitentan for the Treatment of Digital Ulcers in Systemic Sclerosis Patients macitentan 3mg, macitentan 10mg, placebo - Systemic Sclerosis, Ulcers | Phase 3 | Completed | Actelion | 289 | 2011-12-01 | 2015-01-06 |
| A Randomized Control Trial to Assess the Efficacy of Tadalafil in Raynaud's Phenomenon in Scleroderma Tadalafil, Placebo - Raynaud's Phenomenon, Digital Ulcers | Phase 3 | Completed | Sanjay Gandhi Postgraduate Institute of Medical Sciences | 66 | 2009-11-01 | 2010-05-10 |
| Bosentan in Digital Ulcers Bosentan 62.5 mg, Bosentan 125 mg - Digital Ulcers | Phase 3 | Completed | Actelion | 116 | 2004-07-08 | 2025-02-04 |
| Efficacy and Safety of Oral Bosentan on Healing/Prevention of Digital (Finger) Ulcers in Patients With Scleroderma Bosentan 62.5 mg, Bosentan 125 mg, Placebo - Digital Ulcers, Systemic Sclerosis | Phase 3 | Completed | Actelion | 188 | 2003-10-01 | 2025-02-03 |
Scleroderma, Systemic (4) · Scleroderma, Diffuse (2) · Gangrene (1) · Raynaud Disease (1) · Ulcer (1)
Connective Tissue Diseases (5) · Skin Diseases (5) · Skin and Connective Tissue Diseases (5) · Pathologic Processes (2) · Pathological Conditions, Signs and Symptoms (2) · Cardiovascular Diseases (1) · Embolism and Thrombosis (1) · Livedoid Vasculopathy (1) · Necrosis (1) · Peripheral Vascular Diseases (1) · Scleroderma, Systemic (1) · Skin Diseases, Vascular (1) · Thrombosis (1) · Vascular Diseases (1)
Bosentan (2) · macitentan (2) · Tadalafil (1)
Actelion (4) · Sanjay Gandhi Postgraduate Institute of Medical Sciences (1)
India (2) · Australia (1) · Belarus (1) · Bulgaria (1) · Canada (1) · Chile (1) · Colombia (1) · Croatia (1) · Czechia (1) · Denmark (1) · Finland (1) · Germany (1) · Hungary (1) · Italy (1) · Poland (1)
Aman Sharma, MD (1) · Darshan S Bhakuni, MD (1) · James Seibold, MD (1) · Parasar Ghosh, MD, DM (1)