3 recruiting, 3 unknown, 1 not yet recruiting, 1 terminated. 5 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 5 | Unknown 3, Recruiting 1, Terminated 1 |
Follow Costello Syndrome: new trials by email Literature Review of Costello Syndrome trials Research Report on Costello Syndrome
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Clinical Genetics Branch Eligibility Screening Survey Melanoma, Li-Fraumeni Syndrome | Not yet recruiting | National Cancer Institute (NCI) | 1000 | 2026-11-02 | 2026-10-28 | |
| Acceptance and Commitment Therapy for Caregivers of Children With a RASopathy: An Internal Pilot Feasibility Study and Follow-up Randomized Controlled Trial Waitlist, ACT Intervention - Neurofibromatosis 1, Noonan Syndrome | Not applicable | Recruiting | National Cancer Institute (NCI) | 70 | 2024-01-10 | 2026-10-16 |
| Clinical, Genetic, and Epidemiologic Study of Children and Adults With RASopathies Costello Syndrome, Noonan Syndrome | Recruiting | National Cancer Institute (NCI) | 500 | 2022-04-25 | 2026-10-02 | |
| Solid Tumors in RASopathies Molecular characterization of solid tumor in RASopathies - RASopathy, Costello Syndrome | Not applicable | Unknown | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 100 | 2021-10-12 | 2024-04-04 |
| Effect of RAS/MAPK Pathway Hyperactivation on Growth' and Bone' Profile of the RASopathies Diagnostic test - RASopathy, Costello Syndrome | Not applicable | Unknown | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 120 | 2021-04-22 | 2024-03-26 |
| Prevalence and Characterization of Pain in RASopathies Characterization of pain - RASopathy, Costello Syndrome | Not applicable | Unknown | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 150 | 2021-01-27 | 2025-03-21 |
| RASopathy Biorepository RAS Mutation, Neurofibromatosis 1 | Recruiting | Children's Hospital Medical Center, Cincinnati | 1000 | 2017-06-27 | 2025-12-18 | |
| Pathophysiology Analysis of "Costello Syndrome" on Cellular Models Biopsy - Costello Syndrome | Not applicable | Terminated | University Hospital, Bordeaux | 9 | 2015-06-01 | 2026-06-08 |
Cardiofaciocutaneous syndrome (7) · Noonan Syndrome (6) · Legius syndrome (4) · Neurofibromatosis 1 (2) · Capillary Malformation-Arteriovenous Malformation (1) · Chordoma (1) · Congenital Bone Marrow Failure Syndromes (1) · Fanconi Anemia (1) · Genetic Diseases, Inborn (1) · LEOPARD Syndrome (1) · Li-Fraumeni Syndrome (1) · Melanoma (1) · Melanoma, Cutaneous Malignant (1) · Neoplasms (1)
Abnormalities, Multiple (8) · Congenital Abnormalities (8) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (8) · Craniofacial Abnormalities (8) · Musculoskeletal Abnormalities (8) · Musculoskeletal Diseases (8) · Genetic Diseases, Inborn (7) · Skin and Connective Tissue Diseases (7) · Cardiovascular Abnormalities (6) · Cardiovascular Diseases (6) · Connective Tissue Diseases (6) · Heart Defects, Congenital (6) · Heart Diseases (6) · Neoplasms by Histologic Type (3) · Neoplasms, Nerve Tissue (3)
Biopsy (1) · Diagnostic Tests, Routine (1) · Waiting Lists (1)
Fondazione Policlinico Universitario Agostino Gemelli IRCCS (3) · National Cancer Institute (NCI) (3) · Children's Hospital Medical Center, Cincinnati (1) · University Hospital, Bordeaux (1)
United States (4) · Italy (3) · France (1)
Chiara Leoni, MD, PhD (3) · Douglas R Stewart, M.D. (1) · Kathryn N Weaver, MD (1) · Sharon A Savage, M.D. (1) · Staci M Peron, Ph.D. (1)