2 completed, 2 not yet recruiting, 2 withdrawn, 1 recruiting. 8 Phase 2, 1 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 8 | Completed 2, Not yet recruiting 2, Withdrawn 2, Recruiting 1, Terminated 1 |
| Phase 1 | 1 | Terminated 1 |
| Phase 3 | 1 | Completed 1 |
Follow Coccidioidomycosis: new trials by email Literature Review of Coccidioidomycosis trials Research Report on Coccidioidomycosis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Platform Trial for Salvage Consolidation Therapy in Dimorphic Fungi Oteseconazole - Coccidioidomycosis, Blastomycosis | Phase 2 | Not yet recruiting | University of Minnesota | 30 | 2026-12-01 | 2026-09-04 |
| A Phase II Randomized Study to Evaluate Measures for Endpoint Derivation in Patients With Progressive or Refractory Disseminated Coccidioidomycosis Treated With Olorofim Plus Baseline Standard of Care or Placebo Plus Baseline Standard of Care Olorofim, Placebo - Coccidioidomycosis, Disseminated Fungal Infection | Phase 2 | Not yet recruiting | F2G Ltd | 50 | 2026-12-01 | 2026-09-22 |
| Olorofim in Early Coccidioidal Meningitis olorofim - Coccidioidal Meningitis | Phase 2 | Recruiting | Fariba Donovan | 12 | 2026-06-01 | 2026-07-27 |
| SUBA-Itraconazole Therapy for Coccidioidomycosis Refractory or Intolerant to Fluconazole SUBA-itraconazole - Coccidioidomycosis, Valley Fever | Phase 2 | Withdrawn | George R Thompson | 2021-05-15 | 2021-07-19 | |
| Endemic Mycoses Treatment With SUBA-itraconazole vs Itraconazole SUBA itraconazole, Conventional itraconazole - Invasive Fungal Infections | Phase 2 / Phase 3 | Completed | University of Alabama at Birmingham | 88 | 2018-09-17 | 2023-07-07 |
| Evaluate F901318 (Olorofim) Treatment of Invasive Fungal Infections in Participants Lacking Treatment Options Olorofim - Invasive Fungal Infections | Phase 2 | Completed | F2G Biotech GmbH | 203 | 2018-06-06 | 2024-07-10 |
| Sertraline in Addition to Standard of Care Treatment for Coccidioidomycosis Sertraline - Coccidioidomycosis | Phase 2 | Withdrawn | University of California, San Francisco | 2016-11-01 | 2022-03-21 | |
| Safety and PK of Nikkomycin Z for Coccidioides Pneumonia Treatment nikkomycin Z, Placebo - Coccidioidomycosis | Phase 1 / Phase 2 | Terminated | University of Arizona | 6 | 2007-09-01 | 2025-04-16 |
Invasive Fungal Infections (3) · Blastomycosis (2) · Histoplasmosis (2) · Coccidioidal Meningitis (1) · Mycoses (1)
Bacterial Infections and Mycoses (8) · Infections (8) · Mycoses (7) · Dermatomycoses (2) · Lung Diseases (2) · Lung Diseases, Fungal (2) · Respiratory Tract Diseases (2) · Respiratory Tract Infections (2) · Skin Diseases (2) · Skin Diseases, Infectious (2) · Skin and Connective Tissue Diseases (2) · Central Nervous System Diseases (1) · Central Nervous System Fungal Infections (1) · Central Nervous System Infections (1) · Meningitis (1)
olorofim (3) · Itraconazole (2) · Sertraline (1) · nikkomycin (1)
F2G Biotech GmbH (1) · F2G Ltd (1) · Fariba Donovan (1) · George R Thompson (1) · University of Alabama at Birmingham (1) · University of Arizona (1) · University of California, San Francisco (1) · University of Minnesota (1)
United States (6) · Australia (1) · Belgium (1) · Brazil (1) · Egypt (1) · France (1) · Germany (1) · Israel (1) · Netherlands (1) · Panama (1) · Poland (1) · Russia (1) · South Korea (1) · Spain (1) · Thailand (1)
George R Thompson, MD (2) · Andrej Spec, MD (1) · David E Nix, Pharm D (1) · Fariba Donovan, MD, PhD (1) · George R. Thompson, MD (1) · Matthew Pullen, MD (1) · Peter G Pappas, MD (1) · Sharon Chen (1) · Simon Paul, MD (1)
PMID 32457106, PMID 38440302, PMID 40541222, PMID 41914555, PMID 42008658, PMID 42475691