9 recruiting, 4 not yet recruiting. 10 Not applicable, 2 Phase 1, 1 Phase 2, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 10 | Recruiting 8, Not yet recruiting 2 |
| Phase 1 | 2 | Not yet recruiting 1, Recruiting 1 |
| Phase 2 | 1 | Recruiting 1 |
| Phase 3 | 1 | Not yet recruiting 1 |
Follow Clinical High Risk for Psychosis (CHR): new trials by email Literature Review of Clinical High Risk for Psychosis (CHR) trials Research Report on Clinical High Risk for Psychosis (CHR)
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy of Mindfulness in PREventing Progression to Psychosis in Individuals With an Ultra High Risk for Psychosis MBTP : Mindflulness based training for psychosis - Clinical High Risk for Psychosis (CHR) | Not applicable | Not yet recruiting | Centre Psychothérapique de Nancy | 270 | 2029-04-01 | 2026-03-25 |
| Stratification and Treatment in Early Psychosis Study - PROMOTE Cannabidiol (CBD), Placebo - Clinical High Risk for Psychosis (CHR), Clinical High Risk for Psychosis | Phase 3 | Not yet recruiting | University of Oxford | 586 | 2026-12-01 | 2026-10-08 |
| Mobile Thinking Intervention: A Inital Test Mobile Intervention for Biased Thinking - Schizophrenia, Clinical High Risk for Psychosis (CHR) | Not applicable | Not yet recruiting | University of Alabama at Birmingham | 100 | 2026-12-01 | 2026-10-13 |
| A Multimodal Imaging Study of Dopamine in Early Psychosis Methylphenidate (MPH), [11C]raclopride - Clinical High Risk for Psychosis (CHR) | Phase 1 | Not yet recruiting | New York State Psychiatric Institute | 115 | 2026-10-01 | 2026-07-14 |
| Developing a Recovery-Oriented Suicide Prevention Program for Young People at Clinical High Risk for Psychosis Suicide Prevention Intervention, Standard Care (in control arm) - Clinical High Risk for Psychosis (CHR), Suicidal Ideation | Not applicable | Recruiting | University of California, San Diego | 108 | 2026-10-01 | 2026-10-22 |
| Accelerated Neuromodulation Therapy and Neurocomputational Biomarkers in Individuals at Clinical High Risk for Psychosis Active Intermittent Theta Burst Stimulation (BEAM-F3 Targeting), Sham Comparator: Sham iTBS - Clinical High Risk for Psychosis (CHR), Psychotic Disorders | Not applicable | Recruiting | Douglas Mental Health University Institute | 40 | 2026-08-01 | 2026-08-28 |
| Digital Dialectical Behavioural Therapy (d-DBT) for Youth at Clinical High Risk (CHR) for Psychosis d-DBT - Clinical High Risk for Psychosis (CHR) | Not applicable | Recruiting | Centre for Addiction and Mental Health | 60 | 2026-04-28 | 2026-09-09 |
| A Study Exploring Changes in a Variety of Biomarkers Following Dosing With MT1988 in Participants at Clinical High Risk for Psychosis MT1988 Low Dose, MT1988 High Dose, Placebo - Clinical High Risk for Psychosis (CHR) | Phase 1 / Phase 2 | Recruiting | Monument Therapeutics Limited | 150 | 2026-03-03 | 2026-06-08 |
| Experience of UHR and PEP Individuals During Mindfulness: a Qualitative Phenomenological Study Qualitative interview - Clinical High Risk for Psychosis (CHR) | Not applicable | Recruiting | Centre Psychothérapique de Nancy | 20 | 2026-01-19 | 2026-03-30 |
| French Validation of Schizophrenia Proneness Instrument- Child Youth Psychiatric and psychological diagnostic tests - Clinical High Risk for Psychosis (CHR) | Not applicable | Recruiting | Centre Psychothérapique de Nancy | 52 | 2025-02-13 | 2026-04-24 |
| Interventions for Clinical High Risk Youth in Tunisia Cognitive training (CT) plus the neuropsychological educational approach to cognitive remediation (NEAR) model and an Enhanced - Treatment as Usual (E-TAU), Enhanced - Treatment as Usual - Clinical High Risk for Psychosis (CHR) | Not applicable | Recruiting | University of California, Los Angeles | 54 | 2023-09-01 | 2025-11-25 |
| Telehealth Cognitive Behavioral Therapy for Youth at Risk for Psychosis CBT Skills Group for CHR Youth, Individual CBT sessions, CBT Skills Group for Families - Clinical High Risk for Psychosis (CHR) | Not applicable | Recruiting | Icahn School of Medicine at Mount Sinai | 72 | 2023-07-21 | 2026-01-20 |
| Reducing the Duration of Untreated Psychosis in the United States: The Impact of Screening and Systematic Communication Screening Method (SM), Screening and Communication Method (SCM) - First Episode Psychosis (FEP), Clinical High Risk for Psychosis (CHR) | Not applicable | Recruiting | Icahn School of Medicine at Mount Sinai | 912 | 2023-05-01 | 2026-09-18 |
Psychotic Disorders (6) · Communication (1) · Prodromal Symptoms (1) · Schizophrenia (1) · Suicidal Ideation (1) · Suicide (1)
Mental Disorders (7) · Schizophrenia Spectrum and Other Psychotic Disorders (7) · Behavior (2) · Behavioral Symptoms (1) · Pathological Conditions, Signs and Symptoms (1) · Self-Injurious Behavior (1) · Signs and Symptoms (1)
Cannabidiol (1) · Cognitive Training (1) · High-Throughput Screening Assays (1) · Mass Screening (1) · Methylphenidate (1) · Models, Biological (1) · Standard of Care (1)
Centre Psychothérapique de Nancy (3) · Icahn School of Medicine at Mount Sinai (2) · Centre for Addiction and Mental Health (1) · Douglas Mental Health University Institute (1) · Monument Therapeutics Limited (1) · New York State Psychiatric Institute (1) · University of Alabama at Birmingham (1) · University of California, Los Angeles (1) · University of California, San Diego (1) · University of Oxford (1)
United States (5) · Canada (3) · France (3) · Austria (1) · Finland (1) · Germany (1) · Greece (1) · Italy (1) · Netherlands (1) · Spain (1) · Switzerland (1) · Tunisia (1) · United Kingdom (1)
David Benrimoh (1) · Joseph Ventura, Ph.D. (1) · M. Omair Husain, MBBS, MRCPsych (1) · Martha E Shenton, PhD (1) · Philip McGuire, PhD, MD (1) · Scott Woods, M.D. (1) · Vincent Laprevote, PU.PH (1) · Yulia Landa (1) · Yulia Landa, PsyD, MS (1)
R01MH128330 (1), R01MH130354 (1), R01MH144654 (1), R21MH131319 (1), R34MH128502 (1), U01MH137298 (1), U24MH137171 (1)