8 completed, 5 active not recruiting, 4 terminated, 2 recruiting. 17 Phase 2, 4 Phase 1, 2 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 17 | Completed 6, Active not recruiting 5, Recruiting 2, Terminated 2, Withdrawn 2 |
| Phase 1 | 4 | Terminated 2, Completed 1, Unknown 1 |
| Phase 3 | 2 | Completed 2 |
Follow Chronic Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive: new trials by email Literature Review of Chronic Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive trials Research Report on Chronic Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Comparing ATG or Post-Transplant Cyclophosphamide to Calcineurin Inhibitor-Methotrexate as GVHD Prophylaxis After Myeloablative Unrelated Donor Peripheral Blood Stem Cell Transplantation Anti-Thymocyte Globulin, Busulfan, Cyclophosphamide - Acute Lymphoblastic Leukemia in Remission, Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome | Phase 2 | Withdrawn | Fred Hutchinson Cancer Center | 2021-06-01 | 2021-06-30 | |
| Serial Measurements of Molecular and Architectural Responses to Therapy (SMMART) PRIME Trial Abemaciclib, Abiraterone, Afatinib - Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Anatomic Stage IV Breast Cancer AJCC v8 | Phase 1 | Terminated | OHSU Knight Cancer Institute | 2 | 2020-04-01 | 2024-03-04 |
| Triplex Vaccine in Preventing CMV Infection in Patients Undergoing Hematopoietic Stem Cell Transplantation Letermovir, Multi-peptide CMV-Modified Vaccinia Ankara Vaccine, Placebo Administration - Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Acute Lymphoblastic Leukemia | Phase 2 | Active not recruiting | City of Hope Medical Center | 7 | 2019-11-27 | 2025-11-14 |
| Pembrolizumab and Dasatinib, Imatinib Mesylate, or Nilotinib in Treating Patients With Chronic Myeloid Leukemia and Persistently Detectable Minimal Residual Disease Dasatinib, Imatinib Mesylate, Laboratory Biomarker Analysis - Chronic Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Minimal Residual Disease | Phase 2 | Active not recruiting | ECOG-ACRIN Cancer Research Group | 40 | 2019-06-26 | 2026-09-15 |
| Multi-antigen CMV-Modified Vaccinia Ankara Vaccine in Reducing CMV Related Complications in Patients With Blood Cancer Undergoing Donor Stem Cell Transplant Multi-antigen CMV-Modified Vaccinia Ankara Vaccine, Laboratory Biomarker Analysis, Placebo - Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Acute Lymphoblastic Leukemia in Remission | Phase 2 | Withdrawn | City of Hope Medical Center | 2018-12-01 | 2018-11-21 | |
| Testing the Addition of Ruxolitinib to the Usual Treatment (Tyrosine Kinase Inhibitors) for Chronic Myeloid Leukemia Bosutinib, Dasatinib, Laboratory Biomarker Analysis - Chronic Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive | Phase 2 | Active not recruiting | SWOG Cancer Research Network | 81 | 2018-10-24 | 2025-12-18 |
| Fludarabine Phosphate, Cyclophosphamide, Total Body Irradiation, and Donor Stem Cell Transplant in Treating Patients With Blood Cancer Cyclophosphamide, Fludarabine Phosphate, Laboratory Biomarker Analysis - Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Acute Leukemia in Remission | Phase 2 | Terminated | Roswell Park Cancer Institute | 31 | 2017-12-07 | 2025-07-04 |
| Engineered Donor Stem Cell Transplant in Treating Patients With Hematologic Malignancies Cyclophosphamide, Filgrastim, Fludarabine Phosphate - Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia | Phase 1 | Completed | M.D. Anderson Cancer Center | 11 | 2017-01-18 | 2023-02-16 |
| Bosutinib in Treating Patients With Chronic Myeloid Leukemia in Chronic Phase After Frontline TKI Failure Bosutinib, Laboratory Biomarker Analysis - Blasts Under 15 Percent of Bone Marrow Nucleated Cells, Blasts Under 15 Percent of Peripheral Blood White Cells | Phase 2 | Terminated | M.D. Anderson Cancer Center | 8 | 2016-10-28 | 2020-05-11 |
| Personalized NK Cell Therapy in CBT Allogeneic Natural Killer Cell Line NK-92, Anti-Thymocyte Globulin, Busulfan - Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Acute Biphenotypic Leukemia | Phase 2 | Recruiting | M.D. Anderson Cancer Center | 100 | 2016-05-19 | 2026-07-30 |
| Dasatinib and Venetoclax in Treating Patients With Philadelphia Chromosome Positive or BCR-ABL1 Positive Early Chronic Phase Chronic Myelogenous Leukemia Dasatinib, Laboratory Biomarker Analysis, Venetoclax - Chronic Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Philadelphia Chromosome Positive, BCR-ABL1 Positive Chronic Myelogenous Leukemia | Phase 2 | Active not recruiting | M.D. Anderson Cancer Center | 155 | 2016-02-19 | 2026-09-14 |
| Sirolimus and Mycophenolate Mofetil in Preventing GVHD in Patients With Hematologic Malignancies Undergoing HSCT Allogeneic Hematopoietic Stem Cell Transplantation, Laboratory Biomarker Analysis, Mycophenolate Mofetil - Adult Hodgkin Lymphoma, Adult Myelodysplastic Syndrome | Phase 1 | Terminated | Stanford University | 1 | 2016-02-01 | 2018-09-12 |
| Multi-antigen CMV-MVA Triplex Vaccine in Reducing CMV Complications in Patients Previously Infected With CMV and Undergoing Donor Hematopoietic Cell Transplant Laboratory Biomarker Analysis, Multi-peptide CMV-Modified Vaccinia Ankara Vaccine, Placebo - Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Acute Lymphoblastic Leukemia in Remission | Phase 2 | Active not recruiting | City of Hope Medical Center | 102 | 2015-12-21 | 2026-07-28 |
| Vaccine Therapy in Reducing the Frequency of Cytomegalovirus Events in Patients With Hematologic Malignancies Undergoing Donor Stem Cell Transplant CMVpp65-A*0201 peptide vaccine, Placebo, Laboratory Biomarker Analysis - Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Adult Acute Lymphoblastic Leukemia in Remission | Phase 2 | Completed | City of Hope Medical Center | 61 | 2015-05-21 | 2025-03-03 |
| NK Cells in Cord Blood Transplantation Allogeneic Hematopoietic Stem Cell Transplantation, Cyclophosphamide, Fludarabine Phosphate - Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Acute Biphenotypic Leukemia | Phase 1 | Unknown | M.D. Anderson Cancer Center | 13 | 2013-05-03 | 2020-02-11 |
| Ponatinib Hydrochloride as Second Line Therapy in Treating Patients With Chronic Myeloid Leukemia in Chronic Phase Resistant or Intolerant to Imatinib Mesylate, Dasatinib, or Nilotinib Laboratory Biomarker Analysis, Ponatinib Hydrochloride, Quality-of-Life Assessment - Chronic Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Philadelphia Chromosome Positive, BCR-ABL1 Positive Chronic Myelogenous Leukemia | Phase 2 | Recruiting | M.D. Anderson Cancer Center | 50 | 2013-01-17 | 2026-09-16 |
| Eltrombopag Olamine in Treating Thrombocytopenia in Patients With Chronic Myeloid Leukemia or Myelofibrosis Receiving Tyrosine Kinase Therapy Eltrombopag Olamine - Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Blast Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive | Phase 2 / Phase 3 | Completed | M.D. Anderson Cancer Center | 21 | 2012-01-13 | 2023-09-26 |
| Sirolimus, Cyclosporine, and Mycophenolate Mofetil in Preventing Graft-versus-Host Disease in Treating Patients With Blood Cancer Undergoing Donor Peripheral Blood Stem Cell Transplant Allogeneic Hematopoietic Stem Cell Transplantation, Cyclosporine, Fludarabine Phosphate - Adult Acute Lymphoblastic Leukemia, Adult Acute Myeloid Leukemia | Phase 2 | Completed | Fred Hutchinson Cancer Center | 77 | 2010-12-01 | 2019-12-09 |
| Treosulfan, Fludarabine Phosphate, and Total-Body Irradiation in Treating Patients With Hematological Cancer Who Are Undergoing Umbilical Cord Blood Transplant Cyclosporine, Fludarabine Phosphate, Laboratory Biomarker Analysis - Acute Biphenotypic Leukemia, Acute Lymphoblastic Leukemia in Remission | Phase 2 | Completed | Fred Hutchinson Cancer Center | 130 | 2009-02-24 | 2023-02-17 |
| Umbilical Cord Blood Transplant, Cyclophosphamide, Fludarabine, and Total-Body Irradiation in Treating Patients With Hematologic Disease Cyclophosphamide, Cyclosporine, Double-Unit Umbilical Cord Blood Transplantation - Acute Biphenotypic Leukemia, Acute Lymphoblastic Leukemia | Phase 2 | Completed | Fred Hutchinson Cancer Center | 135 | 2005-11-18 | 2025-03-07 |
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Leukemia, Myeloid, Chronic-Phase (22) · Lymphoma, Non-Hodgkin (13) · Hodgkin Disease (12) · Myelodysplastic Syndromes (12) · Leukemia, Lymphocytic, Chronic, B-Cell (11) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (11) · Leukemia, Myeloid, Acute (10) · Primary Myelofibrosis (10) · Leukemia, Myeloid, Accelerated Phase (9) · Leukemia, Myelogenous, Chronic, BCR-ABL Positive (8) · Myeloproliferative Disorders (8) · Multiple Myeloma (6) · Hematologic Neoplasms (5) · Leukemia, Myelomonocytic, Chronic (5) · Blast Crisis (4)
Bone Marrow Diseases (22) · Chronic Disease (22) · Disease Attributes (22) · Hematologic Diseases (22) · Hemic and Lymphatic Diseases (22) · Leukemia (22) · Leukemia, Myeloid (22) · Neoplasms (22) · Neoplasms by Histologic Type (22) · Pathologic Processes (22) · Pathological Conditions, Signs and Symptoms (22) · Immune System Diseases (15) · Immunoproliferative Disorders (15) · Lymphatic Diseases (15) · Lymphoproliferative Disorders (15)
Whole-Body Irradiation (9) · fludarabine phosphate (8) · Cyclophosphamide (6) · Mycophenolic Acid (6) · Cyclosporine (5) · Cyclosporins (5) · Dasatinib (5) · Peripheral Blood Stem Cell Transplantation (5) · Cord Blood Stem Cell Transplantation (4) · CT-P10 (3) · Imatinib Mesylate (3) · Melphalan (3) · Rituximab (3) · Sirolimus (3) · Tacrolimus (3)
M.D. Anderson Cancer Center (8) · Fred Hutchinson Cancer Center (5) · City of Hope Medical Center (4) · ECOG-ACRIN Cancer Research Group (1) · OHSU Knight Cancer Institute (1) · Roswell Park Cancer Institute (1) · SWOG Cancer Research Network (1) · Stanford University (1)
United States (22) · Denmark (1) · Germany (1) · Italy (1)
Ryotaro Nakamura, MD (3) · Brenda Sandmaier (2) · Elias Jabbour, MD (2) · Amer Zeidan (1) · Ann E. Dahlberg (1) · Chitra Hosing (1) · Filippo Milano (1) · Gautam Borthakur (1) · Kendra L Sweet (1) · Lara Davis, MD (1) · Lucia Masarova, MD (1) · Masumi Ueda Oshima (1) · Philip A Thompson (1) · Philip McCarthy, MD (1) · Rajni Agarwal-Hashmi (1)
PMID 10204198, PMID 23620574, PMID 27760761, PMID 28835440, PMID 29723397, PMID 30885996, PMID 31553487, PMID 32040960, PMID 32499241, PMID 32603426, PMID 32706891, PMID 33513367, PMID 37308342, PMID 39863139
P30CA015704 (2), P30CA016672 (2), P01CA018029 (1), P01CA078902 (1), R01CA077544 (1), R01CA181045 (1), R01CA211044 (1), U10CA180820 (1), U10CA180888 (1)