3 completed, 3 recruiting, 2 not yet recruiting, 2 unknown. 2 Phase 1, 2 Phase 2, 1 Not applicable, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 2 | Not yet recruiting 1, Recruiting 1 |
| Phase 2 | 2 | Not yet recruiting 1, Recruiting 1 |
| Not applicable | 1 | Completed 1 |
| Phase 3 | 1 | Recruiting 1 |
Follow Auditory neuropathy: new trials by email Literature Review of Auditory neuropathy trials Research Report on Auditory neuropathy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| First In Human Randomised Trial of Rincell-1 in Adults With a Cochlear Implant Otic neural progenitors, cochlear implantation - Sensorineural Hearing Loss, Presbyacusis | Phase 1 / Phase 2 | Not yet recruiting | Rinri Therapeutics | 20 | 2027-09-01 | 2026-10-01 |
| Genetic Study of OTOF- Related Auditory Neuropathy Spectrum Disorder Whole exome sequencing. - Auditory Neuropathy Spectrum Disorder, Auditory Neuropathy | Not yet recruiting | Sohag University | 30 | 2026-08-01 | 2026-08-21 | |
| A Natural History Study in Pediatric Participants With Hearing Loss Due to OTOF, GJB2, or GJB2/GJB6 Mutations Congenital Hearing Loss Secondary to Biallelic Mutations in the Otoferlin Gene (OTOF), Biallelic Mutations in the Gap Junction Beta 2 (GJB2) Gene | Withdrawn | Regeneron Pharmaceuticals | 2025-06-30 | 2025-05-15 | ||
| Long Term Follow-up Study of AAVAnc80-hOTOF Gene Therapy Otoferlin Gene-mediated Hearing Loss | Enrolling by invitation | Akouos, Inc. | 30 | 2024-11-11 | 2026-04-06 | |
| Gene Therapy Trial for Otoferlin Gene-mediated Hearing Loss AAVAnc80-hOTOF via Akouos Delivery Device, AAVAnc80-hOTOF via Akouos Delivery Device and Precision Delivery Mechanism - Sensorineural Hearing Loss, Bilateral | Phase 3 | Recruiting | Eli Lilly and Company | 48 | 2023-09-15 | 2026-09-29 |
| Prevalence of Peripheral Neuropathy Among Patients With Auditory Neuropathy Pure tone audiometry PTA ,Speech audiometry ,Otoacoustic emission,Auditory evoked potentials including (ABR). - Auditory Neuropathy Spectrum Disorder,, Peripheral Neuropathy | Unknown | Sohag University | 60 | 2023-08-01 | 2023-09-18 | |
| A Study of DB-OTO, an Adeno-Associated Virus (AAV) Based Gene Therapy, in Children/Infants, Adolescents and Adults With Hearing Loss Due to Otoferlin Mutations DB-OTO - Congenital Hearing Loss Secondary to Biallelic Mutations of the Otoferlin Gene (OTOF) | Phase 1 / Phase 2 | Recruiting | Regeneron Pharmaceuticals | 36 | 2023-06-27 | 2026-08-05 |
| Noninvasive Diagnostic Techniques in Determination of Site of Lesion of Auditory Neuropathy Spectrum Disorder extratympanic electrocochleograhy - Auditory Neuropathy | Unknown | Sohag University | 25 | 2022-12-01 | 2022-12-30 | |
| Otoferlin Gene-mediated Hearing Loss Natural History Study Natural History Study - Sensorineural Hearing Loss, Bilateral | Recruiting | Akouos, Inc. | 150 | 2022-07-14 | 2026-03-04 | |
| Evaluation of a Cohort of Congenital Deep Deafness Patients and/or With Auditory Neuropathy, Looking for DFNB9 Data collection, Genetic analysis - Congenital Profound Hearing Loss | Completed | Assistance Publique - Hôpitaux de Paris | 150 | 2020-04-02 | 2026-02-13 | |
| Unexpected ABR Results in Patients Suspected With Auditory Neuropathy Spectrum Disorder Hearing Thresholds Assessments - Auditory Neuropathy | Not applicable | Completed | Istanbul Medipol University Hospital | 11 | 2015-01-20 | 2023-11-09 |
| Auditory Neuropathy and Cochlear Implants Cochlear Implants - Cochlear Implants, Auditory Neuropathy | Completed | University of Sao Paulo | 2006-09-01 | 2009-12-02 |
Hearing Loss, Sensorineural (6) · Deafness, Autosomal Recessive 9 (5) · Hearing Loss (5) · Deafness (3) · Hearing Disorders (2) · Hearing Loss, Bilateral (2) · Hearing Loss, Hidden (1) · Peripheral Nervous System Diseases (1) · Presbycusis (1) · Retrocochlear Diseases (1)
Nervous System Diseases (9) · Ear Diseases (8) · Neurologic Manifestations (8) · Otorhinolaryngologic Diseases (8) · Pathological Conditions, Signs and Symptoms (8) · Sensation Disorders (8) · Signs and Symptoms (8) · Hearing Disorders (6) · Hearing Loss (3) · Neuromuscular Diseases (1)
Cochlear Implantation (1) · Cochlear Implants (1) · Data Collection (1) · Exome (1) · Genetic Testing (1) · OTOF protein, human (1)
Sohag University (3) · Akouos, Inc. (2) · Regeneron Pharmaceuticals (2) · Assistance Publique - Hôpitaux de Paris (1) · Eli Lilly and Company (1) · Istanbul Medipol University Hospital (1) · Rinri Therapeutics (1) · University of Sao Paulo (1)
United States (5) · United Kingdom (4) · Egypt (3) · Spain (3) · Taiwan (3) · Germany (2) · Australia (1) · Brazil (1) · Canada (1) · France (1) · Japan (1) · Turkey (Türkiye) (1)
Douglas Hartley (1) · Peter Marks, M.D. (1) · Peter Marks, MD (1) · Sarah Neuhaus, D.O. (1)
PMID 41085057, PMID 12809326, PMID 19409623, PMID 21860975, PMID 22939890, PMID 26818607, PMID 27340636, PMID 27729456, PMID 28696301, PMID 29111973, PMID 29688962, PMID 30482216, PMID 31453354, PMID 33908410, PMID 34424407, PMID 36769387, PMID 37679651, PMID 40411119, PMID 42279121