78 completed, 46 recruiting, 39 unknown, 15 active not recruiting. 69 Phase 2, 49 Phase 1, 48 Not applicable, 14 Phase 3, 2 Early Phase 1.
Follow Acute Leukemia: new trials by email Literature Review of Acute Leukemia trials Research Report on Acute Leukemia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Real World Assessment of Venous Thromboembolic Risk in Hospitalized Patients With Acute Leukemia Acute Leukemia, Newly Diagnosed Acute Leukemia | Not yet recruiting | Gruppo Italiano Malattie EMatologiche dell'Adulto | 250 | 2027-01-01 | 2026-09-21 | |
| Depletion of CD45RA Positive Naive T Cells for the Prevention of Graft Versus Host Disease in Older Patients Undergoing Allogeneic Hematopoietic Cell Transplantation for Acute Leukemia or Myelodysplastic Syndrome Allogeneic CD34+-enriched and CD45RA-depleted PBSCs, Biospecimen Collection, Bone Marrow Aspiration - Acute Biphenotypic Leukemia, Acute Leukemia | Phase 2 | Not yet recruiting | Fred Hutchinson Cancer Center | 52 | 2027-01-01 | 2026-09-14 |
| Prevention of Oral Mucositis in Adults in With Hematologic Malignancy Aloe Vera Mouthwash, Standard of Care - Acute Leukemia, Acute Myeloid Leukemia | Not applicable | Not yet recruiting | Wake Forest University Health Sciences | 206 | 2027-01-01 | 2026-10-22 |
| Study to Characterize Mismatched to Fully HLA-Matched Ossium HPC, Marrow and Living Donor Transplantation in Patients With Hematologic Malignancies Ossium HPC, Marrow, Standard of care living donor - Haplo Related, Standard of care living donor - Mismatched Unrelated - Hematologic Malignancy, Acute Leukemia | Not applicable | Not yet recruiting | Ossium Health, Inc. | 300 | 2026-12-01 | 2026-09-10 |
| Sirolimus+Ruxolitinib+Mycophenolate Mofetil for Prophylaxis of aGVHD in Patients Receiving Haplo-HSCT Who Are Intolerant to CNI Sirolimus, Ruxolitinib, MMF - Acute Leukemia, Myelodysplastic Syndromes | Phase 1 / Phase 2 | Not yet recruiting | Peking University People's Hospital | 40 | 2026-10-01 | 2026-09-09 |
| Peri-graft Cytokine Profile: Influence of Hematologic Disease and Donor Type Blood sampling - Myelofibrosis, Acute Leukemia | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 96 | 2026-09-15 | 2026-09-04 | |
| Study of QUAIL-100 in Pediatric and Young Adult Participants With High-Risk Hematologic Malignancies Who Have Received a Hematopoietic Stem Cell Transplantation QUAIL-100 - Acute Leukemia, Myelodysplastic Syndrome | Phase 1 | Recruiting | Laguna Biotherapeutics, Inc. | 12 | 2026-08-01 | 2026-08-21 |
| Thiotepa-based Conditioning Regimen With De-escalated Post-graft Cyclophosphamide for Allogeneic Stem Cell Transplantation in Hematologic Malignancies Thiotepa, Fludarabine, Busulfan - Acute Lymphocytic Leukemia (ALL), Acute Myeloid Leukemia (AML) | Phase 1 | Recruiting | Sawa Ito, MD | 48 | 2026-07-27 | 2026-08-18 |
| CD19/BAFF-R in Vivo CAR-T Cell Therapy Targeting Relapsed/Refractory B Cell Acute Leukemia/Malignant Lymphoma CD19/BAFF-R in vivo CAR-T cell intravenous infusion - Lymphoma, CAR T Cell Therapy | Phase 1 | Not yet recruiting | Qi deng | 18 | 2026-06-01 | 2026-02-03 |
| Strength Training Exercise in Pediatric Acute Lymphoblastic Leukemia and Lymphoblastic Lymphoma (STEP-ALL) Exercises - Leukemia, Acute Leukemia | Not applicable | Recruiting | UNC Lineberger Comprehensive Cancer Center | 40 | 2026-05-01 | 2026-08-03 |
| MT2025-35 Allogeneic Hematopoietic Stem Cell Transplantation Using Reduced Intensity Conditioning Treosulfan and Fludarabine, With Post-Transplant Cytoxan (PTCy) for the Treatment of Hematological Diseases Treosulfan, Fludarabine, Total Body Irradiation - AML, MDS | Phase 2 | Recruiting | Masonic Cancer Center, University of Minnesota | 132 | 2026-04-10 | 2026-04-16 |
| Benefits of Formalized Care Support Program Following Acute Leukemia Diagnosis care support program after diagnosis announcement - Acute Leukemia | Not applicable | Recruiting | Centre Henri Becquerel | 110 | 2026-03-30 | 2026-04-29 |
| BY002 IIT Study in R/R Acute Leukemia BY002 - Acute Leukemia, KMT2A Rearrangements or NPM1 Mutations Acute Leukemia | Phase 1 | Recruiting | The First Affiliated Hospital of Soochow University | 18 | 2026-03-15 | 2026-03-18 |
| Artistic and Movement Activities to Reduce Anxiety in Children With Acute Lymphoblastic Leukemia. Art and physical activity program. - Anxiety, Acute Leukemia | Phase 3 | Recruiting | Children's Cancer Hospital Egypt 57357 | 76 | 2026-01-21 | 2026-10-16 |
| A Study of Revumenib and Mezigdomide in People With Leukemia Revumenib, Mezigdomide - Leukemia, Acute Leukemia | Phase 1 / Phase 2 | Recruiting | Memorial Sloan Kettering Cancer Center | 52 | 2026-01-16 | 2026-10-20 |
| Radioimmunotherapy Conditioning With 131I- Apamistamab for Allogeneic Transplant in Relapse/Refractory AML 131I-apamistamab, Fludarabine, Cyclophosphamide - Acute Leukemia, Myeloid Leukemia | Phase 2 / Phase 3 | Not yet recruiting | Actinium Pharmaceuticals | 306 | 2026-01-01 | 2025-09-10 |
| A Real-world Study on the Efficacy and Safety of Menin Inhibitors as Maintenance After Allo-HSCT Menin Inhibitors, Acute Leukemia | Recruiting | The First Affiliated Hospital of Soochow University | 20 | 2025-11-01 | 2026-04-30 | |
| Luspatercept for the Treatment of Anemia Following Allogeneic Hematopoietic Stem Cell Transplantation(Allo-HSCT) Luspatercept - Acute Leukemia | Phase 1 / Phase 2 | Recruiting | Zhujiang Hospital | 46 | 2025-10-01 | 2026-01-23 |
| Gynecological Impact of Allogeneic Hematopoietic Stem Cell Transplantation in Adults Questionnaire - Acute Leukemia | Not applicable | Completed | University Hospital, Bordeaux | 51 | 2025-09-19 | 2026-06-25 |
| Bleeding and Thrombotic Risk Prediction in Acute Leukemia: Clinical Utility of the Siriraj Acute Myeloid/Lymphoblastic Leukemia (SiAML) Score Versus Established Hemostatic Tools Acute Leukemia | Not yet recruiting | Assiut University | 60 | 2025-09-01 | 2025-08-07 |
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Myelodysplastic Syndromes (59) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (50) · Leukemia, Myeloid, Acute (44) · Leukemia (31) · Myeloproliferative Disorders (27) · Leukemia, Myelogenous, Chronic, BCR-ABL Positive (26) · Lymphoma (24) · Hodgkin Disease (21) · Multiple Myeloma (19) · Lymphoma, Non-Hodgkin (18) · Hematologic Neoplasms (15) · Leukemia, Biphenotypic, Acute (13) · Anemia, Refractory, with Excess of Blasts (11) · Leukemia, Lymphocytic, Chronic, B-Cell (10) · Recurrence (10)
Hemic and Lymphatic Diseases (132) · Hematologic Diseases (119) · Neoplasms (101) · Neoplasms by Histologic Type (98) · Immune System Diseases (93) · Bone Marrow Diseases (84) · Immunoproliferative Disorders (82) · Lymphatic Diseases (82) · Lymphoproliferative Disorders (78) · Pathological Conditions, Signs and Symptoms (47) · Leukemia (46) · Leukemia, Lymphoid (46) · Leukemia, Myeloid (46) · Pathologic Processes (43) · Disease Attributes (35)
Cyclophosphamide (28) · fludarabine (26) · Whole-Body Irradiation (20) · Tacrolimus (18) · Busulfan (16) · Mycophenolic Acid (16) · fludarabine phosphate (13) · Melphalan (12) · Antilymphocyte Serum (8) · Filgrastim (8) · Methotrexate (8) · Mesna (7) · Peripheral Blood Stem Cell Transplantation (7) · Sirolimus (7) · Stem Cell Transplantation (7)
Peking University People's Hospital (9) · City of Hope Medical Center (7) · Masonic Cancer Center, University of Minnesota (6) · The First Affiliated Hospital of Soochow University (6) · Fred Hutchinson Cancer Center (4) · Institut Paoli-Calmettes (4) · Memorial Sloan Kettering Cancer Center (4) · Affiliated Hospital to Academy of Military Medical Sciences (3) · Assistance Publique - Hôpitaux de Paris (3) · Assiut University (3) · Azienda Ospedaliero-Universitaria di Parma (3) · Nanfang Hospital, Southern Medical University (3) · Ossium Health, Inc. (3) · Seoul National University Hospital (3) · University of Illinois at Chicago (3)
United States (86) · China (36) · France (22) · Italy (12) · Canada (9) · South Korea (7) · Spain (6) · Brazil (4) · Denmark (4) · Taiwan (4) · United Kingdom (4) · Germany (3) · Australia (2) · Belgium (2) · Egypt (2)
Andrew Hantel, MD (2) · Damiano Rondelli, MD (2) · Hu Chen, M.D., Ph.D. (2) · Jiong HU, M.D. (2) · Marie Bleakley (2) · Mary Horowitz, MD (2) · Mary Jarden, Ph.D. (2) · Phuong Vo, MD (2) · Qifa Liu (2) · Steven Devine, MD (2) · Su-ning Chen, M.D. (2) · Xiao-Jun Huang (2) · A Bacigalupo, Dr. (1) · A Bosi, Dr. (1) · A Ferrant, Dr (1)
PMID 31375516, PMID 33811823, PMID 34847232, PMID 36823396, PMID 37196637, PMID 38017103, PMID 38702786, PMID 39283025, PMID 10339508, PMID 10577848, PMID 12370753, PMID 12393746, PMID 15020610, PMID 15124687, PMID 15197203, PMID 15368330, PMID 15534356, PMID 16423993, PMID 16522815, PMID 16564913, PMID 20117965, PMID 20371346, PMID 20959411, PMID 22589701, PMID 24083543, PMID 24497570, PMID 24641416, PMID 25072733, PMID 25234438, PMID 25310303, PMID 25621950, PMID 25631767, PMID 25644958, PMID 25805929, PMID 25881847, PMID 25983002, PMID 26735993, PMID 26899273, PMID 27036163, PMID 27347147, PMID 27470602, PMID 27916294, PMID 27941097, PMID 28161329, PMID 28412099, PMID 28415728, PMID 29415891, PMID 29431027, PMID 29458388, PMID 29506548
K08CA273043 (2), P01CA018029 (2), P30CA015704 (2), P30CA033572 (2), U01HL069294 (2), 2008 (1), 2023 (1), P01CA049605 (1), R01HL114591 (1), R21CA159265 (1), U10CA031946 (1), U10HL069294 (1), U24CA114725 (1)