Most Influential SCIENCE Papers (2022-02)
Science, also widely referred to as Science Magazine, is the peer-reviewed academic journal of the American Association for the Advancement of Science (AAAS) and one of the world’s top academic journals. Paper Digest Team analyze all papers published on SCIENCE in the past years, and presents the 10 most influential papers for each year (based on when the paper became available online). This ranking list is automatically constructed based upon citations from both research papers and granted patents, and will be frequently updated to reflect the most recent changes. To find the most influential papers from other conferences/journals, visit Best Paper Digest page. Note: the most influential papers may or may not include the papers that won the best paper awards. (Last updated on: 2022-02-05)
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TABLE 1: Most Influential SCIENCE Papers (2022-02)
| Year | Rank | Paper | Author(s) |
|---|---|---|---|
| 2021 | 1 | Estimated Transmissibility and Impact of SARS-CoV-2 Lineage B.1.1.7 in England IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: A severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant, VOC 202012/01 (lineage B.1.1.7), emerged in southeast England in September 2020 and is rapidly spreading … |
NICHOLAS G DAVIES et. al. |
| 2021 | 2 | Immunological Memory to SARS-CoV-2 Assessed for Up to 8 Months After Infection IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Understanding immune memory to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is critical for improving diagnostics and vaccines and for assessing the likely future … |
JENNIFER M DAN et. al. |
| 2021 | 3 | Genomics and Epidemiology of The P.1 SARS-CoV-2 Lineage in Manaus, Brazil IF:6 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in Manaus, Brazil, resurged in late 2020 despite previously high levels of infection. Genome … |
NUNO R FARIA et. al. |
| 2021 | 4 | Accurate Prediction of Protein Structures and Interactions Using A 3-track Neural Network IF:5 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Deep learning takes on protein folding In 1972, Anfinsen won a Nobel prize for demonstrating a connection between a protein’s amino acid sequence and its three-dimensional … |
MINKYUNG BAEK et. al. |
| 2021 | 5 | Neutralization of SARS-CoV-2 Lineage B.1.1.7 Pseudovirus By BNT162b2 Vaccine-elicited Human Sera IF:5 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Recently, a new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lineage called B.1.1.7 (variant of concern: VOC 202012/01), which is reported to spread more … |
ALEXANDER MUIK et. al. |
| 2021 | 6 | Model-informed COVID-19 Vaccine Prioritization Strategies By Age and Serostatus IF:5 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Limited initial supply of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine raises the question of how to prioritize available doses. We used a mathematical … |
KATE M BUBAR et. al. |
| 2021 | 7 | Prospective Mapping of Viral Mutations That Escape Antibodies Used to Treat COVID-19 IF:5 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Antibodies are a potential therapy for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), but the risk of the virus evolving to escape them remains unclear. Here we map … |
TYLER N STARR et. al. |
| 2021 | 8 | MRNA Vaccination Boosts Cross-variant Neutralizing Antibodies Elicited By SARS-CoV-2 Infection IF:4 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Emerging SARS-CoV-2 variants have raised concerns about resistance to neutralizing antibodies elicited by previous infection or vaccination. We examined whether sera from … |
LEONIDAS STAMATATOS et. al. |
| 2021 | 9 | Accurate Prediction of Protein Structures and Interactions Using A Three-track Neural Network IF:4 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: DeepMind presented notably accurate predictions at the recent 14th Critical Assessment of Structure Prediction (CASP14) conference. We explored network architectures that … |
MINKYUNG BAEK et. al. |
| 2021 | 10 | Recurrent Deletions in The SARS-CoV-2 Spike Glycoprotein Drive Antibody Escape IF:4 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Zoonotic pandemics, such as that caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), can follow the spillover of animal viruses into highly susceptible human … |
KEVIN R MCCARTHY et. al. |
| 2020 | 1 | Cryo-EM Structure Of The 2019-nCoV Spike In The Prefusion Conformation IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The outbreak of a novel coronavirus (2019-nCoV) represents a pandemic threat that has been declared a public health emergency of international concern. The CoV spike (S) … |
DANIEL WRAPP et. al. |
| 2020 | 2 | Structural Basis For The Recognition Of SARS-CoV-2 By Full-length Human ACE2 IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Angiotensin-converting enzyme 2 (ACE2) is the cellular receptor for severe acute respiratory syndrome-coronavirus (SARS-CoV) and the new coronavirus (SARS-CoV-2) that is causing … |
RENHONG YAN et. al. |
| 2020 | 3 | Substantial Undocumented Infection Facilitates The Rapid Dissemination of Novel Coronavirus (SARS-CoV-2) IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Estimation of the prevalence and contagiousness of undocumented novel coronavirus [severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2)] infections is critical for … |
RUIYUN LI et. al. |
| 2020 | 4 | The Effect Of Travel Restrictions On The Spread Of The 2019 Novel Coronavirus (COVID-19) Outbreak IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Motivated by the rapid spread of coronavirus disease 2019 (COVID-19) in mainland China, we use a global metapopulation disease transmission model to project the impact of travel … |
MATTEO CHINAZZI et. al. |
| 2020 | 5 | Projecting The Transmission Dynamics of SARS-CoV-2 Through The Postpandemic Period IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: It is urgent to understand the future of severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) transmission. We used estimates of seasonality, immunity, and cross-immunity … |
Stephen M Kissler; Christine Tedijanto; Edward Goldstein; Yonatan H Grad; Marc Lipsitch; |
| 2020 | 6 | Quantifying SARS-CoV-2 Transmission Suggests Epidemic Control with Digital Contact Tracing IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The newly emergent human virus SARS-CoV-2 (severe acute respiratory syndrome-coronavirus 2) is resulting in high fatality rates and incapacitated health systems. Preventing … |
LUCA FERRETTI et. al. |
| 2020 | 7 | The Effect of Human Mobility and Control Measures on The COVID-19 Epidemic in China IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The ongoing coronavirus disease 2019 (COVID-19) outbreak expanded rapidly throughout China. Major behavioral, clinical, and state interventions were undertaken to mitigate the … |
MORITZ U G KRAEMER et. al. |
| 2020 | 8 | Impaired Type I Interferon Activity and Inflammatory Responses in Severe COVID-19 Patients IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Coronavirus disease 2019 (COVID-19) is characterized by distinct patterns of disease progression that suggest diverse host immune responses. We performed an integrated immune … |
JÉRÔME HADJADJ et. al. |
| 2020 | 9 | An Investigation Of Transmission Control Measures During The First 50 Days Of The COVID-19 Epidemic In China IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Responding to an outbreak of a novel coronavirus [agent of coronavirus disease 2019 (COVID-19)] in December 2019, China banned travel to and from Wuhan city on 23 January 2020 and … |
HUAIYU TIAN et. al. |
| 2020 | 10 | Autoantibodies Against Type I IFNs in Patients with Life-threatening COVID-19 IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Interindividual clinical variability in the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is vast. We report that at least 101 of 987 patients … |
PAUL BASTARD et. al. |
| 2019 | 1 | Dissecting Racial Bias in An Algorithm Used to Manage The Health of Populations IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Health systems rely on commercial prediction algorithms to identify and help patients with complex health needs. We show that a widely used algorithm, typical of this … |
Ziad Obermeyer; Brian Powers; Christine Vogeli; Sendhil Mullainathan; |
| 2019 | 2 | Tuning Superconductivity In Twisted Bilayer Graphene IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Materials with flat electronic bands often exhibit exotic quantum phenomena owing to strong correlations. An isolated low-energy flat band can be induced in bilayer graphene by … |
MATTHEW YANKOWITZ et. al. |
| 2019 | 3 | Slide-seq: A Scalable Technology for Measuring Genome-wide Expression at High Spatial Resolution IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Spatial positions of cells in tissues strongly influence function, yet a high-throughput, genome-wide readout of gene expression with cellular resolution is lacking. We developed … |
SAMUEL G RODRIQUES et. al. |
| 2019 | 4 | Emergent Ferromagnetism Near Three-quarters Filling In Twisted Bilayer Graphene IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: When two sheets of graphene are stacked at a small twist angle, the resulting flat superlattice minibands are expected to strongly enhance electron-electron interactions. Here, we … |
AARON L SHARPE et. al. |
| 2019 | 5 | Language And The Brain IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details |
Lera Boroditsky; |
| 2019 | 6 | The Global Tree Restoration Potential IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The restoration of trees remains among the most effective strategies for climate change mitigation. We mapped the global potential tree coverage to show that 4.4 billion hectares … |
JEAN-FRANCOIS BASTIN et. al. |
| 2019 | 7 | Exceptional Points In Optics And Photonics IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Exceptional points are branch point singularities in the parameter space of a system at which two or more eigenvalues, and their corresponding eigenvectors, coalesce and become … |
Mohammad-Ali Miri; Andrea Alù; |
| 2019 | 8 | What Would It Take For Renewably Powered Electrosynthesis To Displace Petrochemical Processes? IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Electrocatalytic transformation of carbon dioxide (CO ) and water into chemical feedstocks offers the potential to reduce carbon emissions by shifting the chemical industry away … |
PHIL DE LUNA et. al. |
| 2019 | 9 | Decline Of The North American Avifauna IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Species extinctions have defined the global biodiversity crisis, but extinction begins with loss in abundance of individuals that can result in compositional and functional … |
KENNETH V ROSENBERG et. al. |
| 2019 | 10 | Two-dimensional Magnetic Crystals And Emergent Heterostructure Devices IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Magnetism, originating from the moving charges and spin of elementary particles, has revolutionized important technologies such as data storage and biomedical imaging, and … |
Cheng Gong; Xiang Zhang; |
| 2018 | 1 | Cancer Immunotherapy Using Checkpoint Blockade IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The release of negative regulators of immune activation (immune checkpoints) that limit antitumor responses has resulted in unprecedented rates of long-lasting tumor responses in … |
Antoni Ribas; Jedd D Wolchok; |
| 2018 | 2 | Organic And Solution-processed Tandem Solar Cells With 17.3% Efficiency IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Although organic photovoltaic (OPV) cells have many advantages, their performance still lags far behind that of other photovoltaic platforms. A fundamental reason for their low … |
LINGXIAN MENG et. al. |
| 2018 | 3 | The Science Of Fake News IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details |
DAVID M J LAZER et. al. |
| 2018 | 4 | A General Reinforcement Learning Algorithm That Masters Chess, Shogi, And Go Through Self-play IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The game of chess is the longest-studied domain in the history of artificial intelligence. The strongest programs are based on a combination of sophisticated search techniques, … |
DAVID SILVER et. al. |
| 2018 | 5 | Shifting The Limits in Wheat Research and Breeding Using A Fully Annotated Reference Genome IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: An annotated reference sequence representing the hexaploid bread wheat genome in 21 pseudomolecules has been analyzed to identify the distribution and genomic context of coding … |
RUDI APPELS et. al. |
| 2018 | 6 | Detection and Localization of Surgically Resectable Cancers with A Multi-analyte Blood Test IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Earlier detection is key to reducing cancer deaths. Here, we describe a blood test that can detect eight common cancer types through assessment of the levels of circulating … |
JOSHUA D COHEN et. al. |
| 2018 | 7 | CAR T Cell Immunotherapy for Human Cancer IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Adoptive T cell transfer (ACT) is a new area of transfusion medicine involving the infusion of lymphocytes to mediate antitumor, antiviral, or anti-inflammatory effects. The field … |
Carl H June; Roddy S O’Connor; Omkar U Kawalekar; Saba Ghassemi; Michael C Milone; |
| 2018 | 8 | Assessing Nature’s Contributions To People IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details |
SANDRA DÍAZ et. al. |
| 2018 | 9 | Coactivator Condensation At Super-enhancers Links Phase Separation And Gene Control IF:7 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Super-enhancers (SEs) are clusters of enhancers that cooperatively assemble a high density of the transcriptional apparatus to drive robust expression of genes with prominent … |
BENJAMIN R SABARI et. al. |
| 2018 | 10 | CRISPR-Cas12a Target Binding Unleashes Indiscriminate Single-stranded DNase Activity IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: CRISPR-Cas12a (Cpf1) proteins are RNA-guided enzymes that bind and cut DNA as components of bacterial adaptive immune systems. Like CRISPR-Cas9, Cas12a has been harnessed for … |
JANICE S CHEN et. al. |
| 2017 | 1 | Combining Theory And Experiment In Electrocatalysis: Insights Into Materials Design IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Electrocatalysis plays a central role in clean energy conversion, enabling a number of sustainable processes for future technologies. This review discusses design strategies for … |
ZHI WEI SEH et. al. |
| 2017 | 2 | Mismatch Repair Deficiency Predicts Response Of Solid Tumors To PD-1 Blockade IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The genomes of cancers deficient in mismatch repair contain exceptionally high numbers of somatic mutations. In a proof-of-concept study, we previously showed that colorectal … |
DUNG T LE et. al. |
| 2017 | 3 | The Spread of True and False News Online IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: We investigated the differential diffusion of all of the verified true and false news stories distributed on Twitter from 2006 to 2017. The data comprise ~126,000 stories tweeted … |
Soroush Vosoughi; Deb Roy; Sinan Aral; |
| 2017 | 4 | A Pathology Atlas Of The Human Cancer Transcriptome IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Cancer is one of the leading causes of death, and there is great interest in understanding the underlying molecular mechanisms involved in the pathogenesis and progression of … |
MATHIAS UHLEN et. al. |
| 2017 | 5 | Efficient And Stable Solution-processed Planar Perovskite Solar Cells Via Contact Passivation IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Planar perovskite solar cells (PSCs) made entirely via solution processing at low temperatures (<150°C) offer promise for simple manufacturing, compatibility with flexible ... |
HAIREN TAN et. al. |
| 2017 | 6 | Liquid Phase Condensation In Cell Physiology And Disease IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Phase transitions are ubiquitous in nonliving matter, and recent discoveries have shown that they also play a key role within living cells. Intracellular liquid-liquid phase … |
Yongdae Shin; Clifford P Brangwynne; |
| 2017 | 7 | Biodiversity Redistribution Under Climate Change: Impacts On Ecosystems And Human Well-being IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Distributions of Earth’s species are changing at accelerating rates, increasingly driven by human-mediated climate change. Such changes are already altering the composition of … |
GRETTA T PECL et. al. |
| 2017 | 8 | Maximizing The Right Stuff: The Trade-off Between Membrane Permeability And Selectivity IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Increasing demands for energy-efficient separations in applications ranging from water purification to petroleum refining, chemicals production, and carbon capture have stimulated … |
Ho Bum Park; Jovan Kamcev; Lloyd M Robeson; Menachem Elimelech; Benny D Freeman; |
| 2017 | 9 | Nucleic Acid Detection With CRISPR-Cas13a/C2c2 IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Rapid, inexpensive, and sensitive nucleic acid detection may aid point-of-care pathogen detection, genotyping, and disease monitoring. The RNA-guided, RNA-targeting clustered … |
JONATHAN S GOOTENBERG et. al. |
| 2017 | 10 | PARP Inhibitors: Synthetic Lethality In The Clinic IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: PARP inhibitors (PARPi), a cancer therapy targeting poly(ADP-ribose) polymerase, are the first clinically approved drugs designed to exploit synthetic lethality, a genetic concept … |
Christopher J Lord; Alan Ashworth; |
| 2016 | 1 | 2D Materials And Van Der Waals Heterostructures IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The physics of two-dimensional (2D) materials and heterostructures based on such crystals has been developing extremely fast. With these new materials, truly 2D physics has begun … |
K S Novoselov; A Mishchenko; A Carvalho; A H Castro Neto; |
| 2016 | 2 | Incorporation Of Rubidium Cations Into Perovskite Solar Cells Improves Photovoltaic Performance IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: All of the cations currently used in perovskite solar cells abide by the tolerance factor for incorporation into the lattice. We show that the small and oxidation-stable rubidium … |
MICHAEL SALIBA et. al. |
| 2016 | 3 | Active Sites Of Nitrogen-doped Carbon Materials For Oxygen Reduction Reaction Clarified Using Model Catalysts IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Nitrogen (N)-doped carbon materials exhibit high electrocatalytic activity for the oxygen reduction reaction (ORR), which is essential for several renewable energy systems. … |
DONGHUI GUO et. al. |
| 2016 | 4 | Electromagnetic Interference Shielding With 2D Transition Metal Carbides (MXenes) IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Materials with good flexibility and high conductivity that can provide electromagnetic interference (EMI) shielding with minimal thickness are highly desirable, especially if they … |
FAISAL SHAHZAD et. al. |
| 2016 | 5 | A Mixed-cation Lead Mixed-halide Perovskite Absorber For Tandem Solar Cells IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Metal halide perovskite photovoltaic cells could potentially boost the efficiency of commercial silicon photovoltaic modules from ∼20 toward 30% when used in tandem architectures. … |
DAVID P MCMEEKIN et. al. |
| 2016 | 6 | Clonal Neoantigens Elicit T Cell Immunoreactivity and Sensitivity to Immune Checkpoint Blockade IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: As tumors grow, they acquire mutations, some of which create neoantigens that influence the response of patients to immune checkpoint inhibitors. We explored the impact of … |
NICHOLAS MCGRANAHAN et. al. |
| 2016 | 7 | Metalenses At Visible Wavelengths: Diffraction-limited Focusing And Subwavelength Resolution Imaging IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Subwavelength resolution imaging requires high numerical aperture (NA) lenses, which are bulky and expensive. Metasurfaces allow the miniaturization of conventional refractive … |
MOHAMMADREZA KHORASANINEJAD et. al. |
| 2016 | 8 | Optically Resonant Dielectric Nanostructures IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Rapid progress in nanophotonics is driven by the ability of optically resonant nanostructures to enhance near-field effects controlling far-field scattering through intermodal … |
Arseniy I Kuznetsov; Andrey E Miroshnichenko; Mark L Brongersma; Yuri S Kivshar; Boris Luk’yanchuk; |
| 2016 | 9 | Complement And Microglia Mediate Early Synapse Loss In Alzheimer Mouse Models IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Synapse loss in Alzheimer’s disease (AD) correlates with cognitive decline. Involvement of microglia and complement in AD has been attributed to neuroinflammation, prominent late … |
SOYON HONG et. al. |
| 2016 | 10 | The Anthropocene Is Functionally And Stratigraphically Distinct From The Holocene IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Human activity is leaving a pervasive and persistent signature on Earth. Vigorous debate continues about whether this warrants recognition as a new geologic time unit known as the … |
COLIN N WATERS et. al. |
| 2015 | 1 | Neoantigens in Cancer Immunotherapy IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The clinical relevance of T cells in the control of a diverse set of human cancers is now beyond doubt. However, the nature of the antigens that allow the immune system to … |
Ton N Schumacher; Robert D Schreiber; |
| 2015 | 2 | The Future Of Immune Checkpoint Therapy IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Immune checkpoint therapy, which targets regulatory pathways in T cells to enhance antitumor immune responses, has led to important clinical advances and provided a new weapon … |
Padmanee Sharma; James P Allison; |
| 2015 | 3 | Machine Learning: Trends, Perspectives, And Prospects IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Machine learning addresses the question of how to build computers that improve automatically through experience. It is one of today’s most rapidly growing technical fields, lying … |
M I Jordan; T M Mitchell; |
| 2015 | 4 | Dissecting The Multicellular Ecosystem Of Metastatic Melanoma By Single-cell RNA-seq IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: To explore the distinct genotypic and phenotypic states of melanoma tumors, we applied single-cell RNA sequencing (RNA-seq) to 4645 single cells isolated from 19 patients, … |
ITAY TIROSH et. al. |
| 2015 | 5 | Human-level Concept Learning Through Probabilistic Program Induction IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: People learning new concepts can often generalize successfully from just a single example, yet machine learning algorithms typically require tens or hundreds of examples to … |
Brenden M Lake; Ruslan Salakhutdinov; Joshua B Tenenbaum; |
| 2015 | 6 | Bee Declines Driven By Combined Stress From Parasites, Pesticides, And Lack Of Flowers IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Bees are subject to numerous pressures in the modern world. The abundance and diversity of flowers has declined; bees are chronically exposed to cocktails of agrochemicals, and … |
Dave Goulson; Elizabeth Nicholls; Cristina Botías; Ellen L Rotheray; |
| 2015 | 7 | Overcoming The Electroluminescence Efficiency Limitations Of Perovskite Light-emitting Diodes IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Organic-inorganic hybrid perovskites are emerging low-cost emitters with very high color purity, but their low luminescent efficiency is a critical drawback. We boosted the … |
HIMCHAN CHO et. al. |
| 2015 | 8 | Anticancer Immunotherapy By CTLA-4 Blockade Relies On The Gut Microbiota IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Antibodies targeting CTLA-4 have been successfully used as cancer immunotherapy. We find that the antitumor effects of CTLA-4 blockade depend on distinct Bacteroides species. In … |
MARIE VÉTIZOU et. al. |
| 2015 | 9 | Genomic Correlates Of Response To CTLA-4 Blockade In Metastatic Melanoma IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Monoclonal antibodies directed against cytotoxic T lymphocyte-associated antigen-4 (CTLA-4), such as ipilimumab, yield considerable clinical benefit for patients with metastatic … |
ELIEZER M VAN ALLEN et. al. |
| 2015 | 10 | Rationally Engineered Cas9 Nucleases With Improved Specificity IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The RNA-guided endonuclease Cas9 is a versatile genome-editing tool with a broad range of applications from therapeutics to functional annotation of genes. Cas9 creates … |
IAN M SLAYMAKER et. al. |
| 2014 | 1 | Single-cell RNA-seq Highlights Intratumoral Heterogeneity in Primary Glioblastoma IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Human cancers are complex ecosystems composed of cells with distinct phenotypes, genotypes, and epigenetic states, but current models do not adequately reflect tumor composition … |
ANOOP P PATEL et. al. |
| 2014 | 2 | A Fracture-resistant High-entropy Alloy For Cryogenic Applications IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: High-entropy alloys are equiatomic, multi-element systems that can crystallize as a single phase, despite containing multiple elements with different crystal structures. A … |
BERND GLUDOVATZ et. al. |
| 2014 | 3 | Lignin Valorization: Improving Lignin Processing In The Biorefinery IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Research and development activities directed toward commercial production of cellulosic ethanol have created the opportunity to dramatically increase the transformation of lignin … |
ARTHUR J RAGAUSKAS et. al. |
| 2014 | 4 | Defaunation In The Anthropocene IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: We live amid a global wave of anthropogenically driven biodiversity loss: species and population extirpations and, critically, declines in local species abundance. Particularly, … |
RODOLFO DIRZO et. al. |
| 2014 | 5 | The Biodiversity Of Species And Their Rates Of Extinction, Distribution, And Protection IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Recent studies clarify where the most vulnerable species live, where and how humanity changes the planet, and how this drives extinctions. We assess key statistics about species, … |
S L PIMM et. al. |
| 2014 | 6 | Nanoporous BiVO4 Photoanodes With Dual-layer Oxygen Evolution Catalysts For Solar Water Splitting IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Bismuth vanadate (BiVO4) has a band structure that is well-suited for potential use as a photoanode in solar water splitting, but it suffers from poor electron-hole separation. … |
Tae Woo Kim; Kyoung-Shin Choi; |
| 2014 | 7 | Highly Crystalline Multimetallic Nanoframes With Three-dimensional Electrocatalytic Surfaces IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Control of structure at the atomic level can precisely and effectively tune catalytic properties of materials, enabling enhancement in both activity and durability. We synthesized … |
CHEN CHEN et. al. |
| 2014 | 8 | Water Photolysis At 12.3% Efficiency Via Perovskite Photovoltaics And Earth-abundant Catalysts IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Although sunlight-driven water splitting is a promising route to sustainable hydrogen fuel production, widespread implementation is hampered by the expense of the necessary … |
JINGSHAN LUO et. al. |
| 2014 | 9 | Phylogenomics Resolves The Timing and Pattern of Insect Evolution IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Insects are the most speciose group of animals, but the phylogenetic relationships of many major lineages remain unresolved. We inferred the phylogeny of insects from 1478 … |
BERNHARD MISOF et. al. |
| 2014 | 10 | Precise And Ultrafast Molecular Sieving Through Graphene Oxide Membranes IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Graphene-based materials can have well-defined nanometer pores and can exhibit low frictional water flow inside them, making their properties of interest for filtration and … |
R K JOSHI et. al. |
| 2013 | 1 | Multiplex Genome Engineering Using CRISPR/Cas Systems IF:10 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Functional elucidation of causal genetic variants and elements requires precise genome editing technologies. The type II prokaryotic CRISPR (clustered regularly interspaced short … |
LE CONG et. al. |
| 2013 | 2 | The Chemistry And Applications Of Metal-organic Frameworks IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Crystalline metal-organic frameworks (MOFs) are formed by reticular synthesis, which creates strong bonds between inorganic and organic units. Careful selection of MOF … |
Hiroyasu Furukawa; Kyle E Cordova; Michael O’Keeffe; Omar M Yaghi; |
| 2013 | 3 | RNA-guided Human Genome Engineering Via Cas9 IF:10 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Bacteria and archaea have evolved adaptive immune defenses, termed clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated (Cas) systems, that use … |
PRASHANT MALI et. al. |
| 2013 | 4 | Electron-hole Diffusion Lengths Exceeding 1 Micrometer In An Organometal Trihalide Perovskite Absorber IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Organic-inorganic perovskites have shown promise as high-performance absorbers in solar cells, first as a coating on a mesoporous metal oxide scaffold and more recently as a solid … |
SAMUEL D STRANKS et. al. |
| 2013 | 5 | High-resolution Global Maps Of 21st-century Forest Cover Change IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Quantification of global forest change has been lacking despite the recognized importance of forest ecosystem services. In this study, Earth observation satellite data were used … |
M C HANSEN et. al. |
| 2013 | 6 | Long-range Balanced Electron- And Hole-transport Lengths In Organic-inorganic CH3NH3PbI3 IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Low-temperature solution-processed photovoltaics suffer from low efficiencies because of poor exciton or electron-hole diffusion lengths (typically about 10 nanometers). Recent … |
GUICHUAN XING et. al. |
| 2013 | 7 | Carbon Nanotubes: Present And Future Commercial Applications IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Worldwide commercial interest in carbon nanotubes (CNTs) is reflected in a production capacity that presently exceeds several thousand tons per year. Currently, bulk CNT powders … |
Michael F L De Volder; Sameh H Tawfick; Ray H Baughman; A John Hart; |
| 2013 | 8 | Genome-scale CRISPR-Cas9 Knockout Screening in Human Cells IF:10 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The simplicity of programming the CRISPR (clustered regularly interspaced short palindromic repeats)-associated nuclease Cas9 to modify specific genomic loci suggests a new way to … |
OPHIR SHALEM et. al. |
| 2013 | 9 | The Microbial Metabolites, Short-chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Regulatory T cells (Tregs) that express the transcription factor Foxp3 are critical for regulating intestinal inflammation. Candidate microbe approaches have identified bacterial … |
PATRICK M SMITH et. al. |
| 2013 | 10 | Sleep Drives Metabolite Clearance from The Adult Brain IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The conservation of sleep across all animal species suggests that sleep serves a vital function. We here report that sleep has a critical function in ensuring metabolic … |
LULU XIE et. al. |
| 2012 | 1 | Efficient Hybrid Solar Cells Based On Meso-superstructured Organometal Halide Perovskites IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The energy costs associated with separating tightly bound excitons (photoinduced electron-hole pairs) and extracting free charges from highly disordered low-mobility networks … |
Michael M Lee; Joël Teuscher; Tsutomu Miyasaka; Takurou N Murakami; Henry J Snaith; |
| 2012 | 2 | Laser Scribing Of High-performance And Flexible Graphene-based Electrochemical Capacitors IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Although electrochemical capacitors (ECs), also known as supercapacitors or ultracapacitors, charge and discharge faster than batteries, they are still limited by low energy … |
Maher F El-Kady; Veronica Strong; Sergey Dubin; Richard B Kaner; |
| 2012 | 3 | Photoacoustic Tomography: in Vivo Imaging from Organelles to Organs IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Photoacoustic tomography (PAT) can create multiscale multicontrast images of living biological structures ranging from organelles to organs. This emerging technology overcomes the … |
Lihong V Wang; Song Hu; |
| 2012 | 4 | Host-gut Microbiota Metabolic Interactions IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The composition and activity of the gut microbiota codevelop with the host from birth and is subject to a complex interplay that depends on the host genome, nutrition, and … |
JEREMY K NICHOLSON et. al. |
| 2012 | 5 | Interactions Between The Microbiota and The Immune System IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The large numbers of microorganisms that inhabit mammalian body surfaces have a highly coevolved relationship with the immune system. Although many of these microbes carry out … |
Lora V Hooper; Dan R Littman; Andrew J Macpherson; |
| 2012 | 6 | Systematic Localization of Common Disease-associated Variation in Regulatory DNA IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Genome-wide association studies have identified many noncoding variants associated with common diseases and traits. We show that these variants are concentrated in regulatory DNA … |
MATTHEW T MAURANO et. al. |
| 2012 | 7 | Signatures Of Majorana Fermions In Hybrid Superconductor-semiconductor Nanowire Devices IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Majorana fermions are particles identical to their own antiparticles. They have been theoretically predicted to exist in topological superconductors. Here, we report electrical … |
V MOURIK et. al. |
| 2012 | 8 | Spin-torque Switching With The Giant Spin Hall Effect Of Tantalum IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Spin currents can apply useful torques in spintronic devices. The spin Hall effect has been proposed as a source of spin current, but its modest strength has limited its … |
LUQIAO LIU et. al. |
| 2012 | 9 | Cyclic GMP-AMP Synthase Is A Cytosolic DNA Sensor That Activates The Type I Interferon Pathway IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The presence of DNA in the cytoplasm of mammalian cells is a danger signal that triggers host immune responses such as the production of type I interferons. Cytosolic DNA induces … |
Lijun Sun; Jiaxi Wu; Fenghe Du; Xiang Chen; Zhijian J Chen; |
| 2012 | 10 | Field-effect Tunneling Transistor Based On Vertical Graphene Heterostructures IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: An obstacle to the use of graphene as an alternative to silicon electronics has been the absence of an energy gap between its conduction and valence bands, which makes it … |
L BRITNELL et. al. |
| 2011 | 1 | Electrical Energy Storage For The Grid: A Battery Of Choices IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The increasing interest in energy storage for the grid can be attributed to multiple factors, including the capital costs of managing peak demands, the investments needed for grid … |
Bruce Dunn; Haresh Kamath; Jean-Marie Tarascon; |
| 2011 | 2 | Light Propagation With Phase Discontinuities: Generalized Laws Of Reflection And Refraction IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Conventional optical components rely on gradual phase shifts accumulated during light propagation to shape light beams. New degrees of freedom are attained by introducing abrupt … |
NANFANG YU et. al. |
| 2011 | 3 | Carbon-based Supercapacitors Produced By Activation Of Graphene IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Supercapacitors, also called ultracapacitors or electrochemical capacitors, store electrical charge on high-surface-area conducting materials. Their widespread use is limited by … |
YANWU ZHU et. al. |
| 2011 | 4 | Two-dimensional Nanosheets Produced By Liquid Exfoliation Of Layered Materials IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: If they could be easily exfoliated, layered materials would become a diverse source of two-dimensional crystals whose properties would be useful in applications ranging from … |
JONATHAN N COLEMAN et. al. |
| 2011 | 5 | Increasing Solar Absorption For Photocatalysis With Black Hydrogenated Titanium Dioxide Nanocrystals IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: When used as a photocatalyst, titanium dioxide (TiO(2)) absorbs only ultraviolet light, and several approaches, including the use of dopants such as nitrogen, have been taken to … |
Xiaobo Chen; Lei Liu; Peter Y Yu; Samuel S Mao; |
| 2011 | 6 | Linking Long-term Dietary Patterns With Gut Microbial Enterotypes IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Diet strongly affects human health, partly by modulating gut microbiome composition. We used diet inventories and 16S rDNA sequencing to characterize fecal samples from 98 … |
GARY D WU et. al. |
| 2011 | 7 | The Future Of Seawater Desalination: Energy, Technology, And The Environment IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: In recent years, numerous large-scale seawater desalination plants have been built in water-stressed countries to augment available water resources, and construction of new … |
Menachem Elimelech; William A Phillip; |
| 2011 | 8 | The Unfolded Protein Response: From Stress Pathway To Homeostatic Regulation IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The vast majority of proteins that a cell secretes or displays on its surface first enter the endoplasmic reticulum (ER), where they fold and assemble. Only properly assembled … |
Peter Walter; David Ron; |
| 2011 | 9 | A Perspective On Cancer Cell Metastasis IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Metastasis causes most cancer deaths, yet this process remains one of the most enigmatic aspects of the disease. Building on new mechanistic insights emerging from recent … |
Christine L Chaffer; Robert A Weinberg; |
| 2011 | 10 | Rapid Range Shifts Of Species Associated With High Levels Of Climate Warming IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: The distributions of many terrestrial organisms are currently shifting in latitude or elevation in response to changing climate. Using a meta-analysis, we estimated that the … |
I-Ching Chen; Jane K Hill; Ralf Ohlemüller; David B Roy; Chris D Thomas; |
| 2010 | 1 | Food Security: The Challenge Of Feeding 9 Billion People IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Continuing population and consumption growth will mean that the global demand for food will increase for at least another 40 years. Growing competition for land, water, and … |
H CHARLES J GODFRAY et. al. |
| 2010 | 2 | Global Biodiversity: Indicators Of Recent Declines IF:8 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: In 2002, world leaders committed, through the Convention on Biological Diversity, to achieve a significant reduction in the rate of biodiversity loss by 2010. We compiled 31 … |
STUART H M BUTCHART et. al. |
| 2010 | 3 | Materials And Mechanics For Stretchable Electronics IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Recent advances in mechanics and materials provide routes to integrated circuits that can offer the electrical properties of conventional, rigid wafer-based technologies but with … |
John A Rogers; Takao Someya; Yonggang Huang; |
| 2010 | 4 | Lipid Rafts As A Membrane-organizing Principle IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Cell membranes display a tremendous complexity of lipids and proteins designed to perform the functions cells require. To coordinate these functions, the membrane is able to … |
Daniel Lingwood; Kai Simons; |
| 2010 | 5 | Fate Mapping Analysis Reveals That Adult Microglia Derive From Primitive Macrophages IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Microglia are the resident macrophages of the central nervous system and are associated with the pathogenesis of many neurodegenerative and brain inflammatory diseases; however, … |
FLORENT GINHOUX et. al. |
| 2010 | 6 | A Draft Sequence Of The Neandertal Genome IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Neandertals, the closest evolutionary relatives of present-day humans, lived in large parts of Europe and western Asia before disappearing 30,000 years ago. We present a draft … |
RICHARD E GREEN et. al. |
| 2010 | 7 | Induction Of Colonic Regulatory T Cells By Indigenous Clostridium Species IF:10 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: CD4(+) T regulatory cells (T(regs)), which express the Foxp3 transcription factor, play a critical role in the maintenance of immune homeostasis. Here, we show that in mice, … |
KOJI ATARASHI et. al. |
| 2010 | 8 | Ultrahigh Porosity In Metal-organic Frameworks IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Crystalline solids with extended non-interpenetrating three-dimensional crystal structures were synthesized that support well-defined pores with internal diameters of up to 48 … |
HIROYASU FURUKAWA et. al. |
| 2010 | 9 | Long Noncoding RNA As Modular Scaffold Of Histone Modification Complexes IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Long intergenic noncoding RNAs (lincRNAs) regulate chromatin states and epigenetic inheritance. Here, we show that the lincRNA HOTAIR serves as a scaffold for at least two … |
MIAO-CHIH TSAI et. al. |
| 2010 | 10 | Development Of Monocytes, Macrophages, And Dendritic Cells IF:9 Related Papers Related Patents Related Grants Related Orgs Related Experts Details Abstract: Monocytes and macrophages are critical effectors and regulators of inflammation and the innate immune response, the immediate arm of the immune system. Dendritic cells initiate … |
FREDERIC GEISSMANN et. al. |