9 completed, 5 terminated. 8 Phase 2, 6 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 8 | Completed 4, Terminated 4 |
| Phase 1 | 6 | Completed 5, Terminated 1 |
| Phase 3 | 1 | Terminated 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Nimotuzumab With Radiotherapy in the Treatment of Anal Canal Cancers Nimotuzumab, Intensity Modulated Radiation Therapy (IMRT) - Squamous Cell Carcinoma of Anal Canal | Phase 2 | Terminated | Dr. Te Vuong | 1 | 2012-01-01 | 2013-01-28 |
| A Study of Nimotuzumab in Combination With Radiation Therapy in Patients With Brain Metastases nimotuzumab - Metastatic Non-Small Cell Lung Cancer | Phase 2 | Terminated | YM BioSciences | 21 | 2009-04-01 | 2011-07-01 |
| A Study of Nimotuzumab in Combination With External Radiotherapy in Non-Small Cell Lung Cancer External radiotherapy, nimotuzumab - Non-small-cell Lung Cancer | Phase 1 / Phase 2 | Terminated | YM BioSciences | 52 | 2009-03-01 | 2011-07-01 |
| Phase 2 Study of Nimotuzumab in Pediatric Recurrent Diffuse Intrinsic Pontine Glioma nimotuzumab (anti EGFR humanized monoclonal antibody) - Recurrent Diffuse Pontine Gliomas | Phase 2 | Completed | YM BioSciences | 44 | 2007-10-01 | 2011-07-06 |
| Study of Nimotuzumab and Irinotecan in Metastatic Colorectal Cancer Nimotuzumab Humanized Monoclonal Antibody, Nimotuzumab - Colorectal Cancer | Phase 2 | Terminated | YM BioSciences | 100 | 2007-06-01 | 2008-11-17 |
| Tesmilifene in Combination With Docetaxel in the Treatment of Metastatic Breast Cancer Tesmilifene (YMB1002) - Metastatic Breast Cancer | Phase 2 | Completed | YM BioSciences | 33 | 2006-06-01 | 2009-01-09 |
| Study to Determine Efficacy and Safety of Inhaled AeroLEF in the Treatment of Acute Post-op Pain in Adult Patients Undergoing Elective Orthopedic Surgery AeroLEF - Pain | Phase 2 | Completed | YM BioSciences | 123 | 2006-01-01 | 2007-06-27 |
| Phase I Study of Nimotuzumab in Solid Tumours Nimotuzumab (TheraCIM h-R3) - Advanced and/or Metastatic Solid Tumours | Phase 1 | Completed | YM BioSciences | 18 | 2005-06-01 | 2007-02-28 |
| Pharmacokinetic Study of Tesmilifene (YMB1002) Plus Epirubicin and Cyclophosphamide in Metastatic Breast Cancer Tesmilifene (YMB 1002) - Metastatic/Recurrent Breast Cancer | Phase 1 | Completed | YM BioSciences | 28 | 2004-05-01 | 2014-04-21 |
| DPPE in Combination With Epirubicin and Cyclophosphamide in the Treatment of Breast Cancer YMB 1002 - Breast Cancer, Metastases | Phase 3 | Terminated | YM BioSciences | 700 | 2004-05-01 | 2007-02-28 |
| Phase II Study of Inhaled AeroLEF for Analgesia After ACL Knee Surgery AeroLEF - Pain, Post Operative Pain | Phase 2 | Completed | YM BioSciences | 19 | 2004-02-01 | 2008-11-17 |
| Study Evaluating Inhaled AeroLEF Delivered in 4 Aerosol Delivery Devices in Healthy Volunteers i.v fentanyl, AeroLEF - Healthy | Phase 1 | Completed | YM BioSciences | 9 | 2003-03-01 | 2008-11-19 |
| Study of Single and Multiple Doses of Inhaled AeroLEF (Liposome-Encapsulated Fentanyl)in Healthy Subjects i.v. fentanyl, 3 mL AeroLEF (500 µg/1 mL) - Healthy | Phase 1 | Completed | YM BioSciences | 12 | 2001-12-01 | 2008-07-03 |
| Study Evaluating Inhaled AeroLEF (Liposome-Encapsulated Fentanyl)in Normal Healthy Subjects i.v. fentanyl and AeroLEF - Healthy | Phase 1 | Completed | YM BioSciences | 6 | 2001-10-01 | 2008-07-02 |
Breast Neoplasms (3) · Carcinoma, Non-Small-Cell Lung (2) · Pain (2) · Agnosia (1) · Brain Neoplasms (1) · Colorectal Neoplasms (1) · Diffuse Intrinsic Pontine Glioma (1) · Neoplasm Metastasis (1) · Pain, Postoperative (1) · Respiratory Aspiration (1)
nimotuzumab (6) · Fentanyl (2) · tesmilifene (2) · Radiotherapy, Intensity-Modulated (1)
Canada (10) · United States (3) · Cuba (1) · Georgia (1) · Israel (1) · Pakistan (1) · Russia (1) · Serbia (1) · Singapore (1) · South Korea (1) · Ukraine (1) · United Kingdom (1)
Diana Pilura, PhD (2) · Paul Y Tam, MD, FACP (2) · Alexander John M Clark, MD FRCPC (1) · Amil Shah, MD (1) · Anthony Brade, M.D. (1) · Anthony Brade, MD (1) · Edward M Sellers, MD (1) · Eric Bouffet, MD (1) · Eric Chen, MD (1) · Gwyn Bebb, MD (1) · Igor Sherman, PhD (1) · Kathleen Pritchard, MD (1) · Kenneth Chisholm, M.D (1) · Lillian Siu, MD (1) · Sylvain Baruchel, MD (1)