18 completed, 1 terminated. 14 Phase 2, 4 Phase 3, 2 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 14 | Completed 13, Terminated 1 |
| Phase 3 | 4 | Completed 4 |
| Phase 1 | 2 | Completed 2 |
Follow Xeris Pharmaceuticals: new trials by email
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study of XP-8121 For the Treatment of Adult Subjects With Hypothyroidism levothyroxine sodium - Hypothyroidism | Phase 2 | Completed | Xeris Pharmaceuticals | 46 | 2023-05-15 | 2025-07-03 |
| Glucagon Ready-to-Use (RTU) for Prevention of Exercise-Induced Hypoglycemia During Aerobic Exercise in Adults With T1D Glucagon RTU Injection With Insulin Pump Reduction, Vehicle for Glucagon RTU Injection With Insulin Pump Reduction, Glugaon RTU Injection Without Insulin Pump Reduction - Hypoglycemia | Phase 2 | Completed | Xeris Pharmaceuticals | 48 | 2019-08-22 | 2025-08-22 |
| Phase 2, Randomized, Open-Label, Crossover, PD/PK Study of a Novel Pram-Insulin Co-Formulation in Adults With T1D PRAM9, Regular Insulin + Pramlintide, Regular Insulin - Diabetes Mellitus, Type 1, Insulin-dependent Diabetes Mellitus | Phase 2 | Completed | Xeris Pharmaceuticals | 18 | 2019-08-22 | 2024-03-27 |
| Glucagon Ready to Use (RTU) in Subjects With Hyperinsulinemic Hypoglycemia After Bariatric Surgery Glucagon RTU, Placebo - Hyperinsulinemic Hypoglycemia | Phase 2 | Completed | Xeris Pharmaceuticals | 14 | 2019-05-10 | 2020-05-21 |
| G-Pen Compared to Glucagen Hypokit for Severe Hypoglycemia Rescue in Adults With Type 1 Diabetes G-Pen, Novo Glucagon - Insulin Hypoglycemia, Type 1 Diabetes Mellitus | Phase 3 | Completed | Xeris Pharmaceuticals | 132 | 2018-09-27 | 2020-05-22 |
| Three Way Crossover Closed Loop Study With Xeris Glucagon Artificial Pancreas Controller in Dual Hormone Mode, Artificial Pancreas Controller in Single Hormone Mode, Artificial Pancreas Controller in Predictive Low Glucose Suspend Mode - Type1diabetes | Phase 1 | Completed | Oregon Health and Science University | 23 | 2018-03-29 | 2020-05-27 |
| Glucagon Infusion in T1D Patients With Recurrent Severe Hypoglycemia: Effects on Counter-Regulatory Responses Glucagon, Placebo - Hypoglycemia Unawareness, Diabetes Mellitus, Type 1 | Phase 2 | Terminated | Xeris Pharmaceuticals | 49 | 2018-03-15 | 2021-02-21 |
| G-Pen™ Compared to Lilly Glucagon for Hypoglycemia Rescue in Adults With Type 1 Diabetes G-Pen, Lilly Glucagon - Insulin Hypoglycemia, Type 1 Diabetes Mellitus | Phase 3 | Completed | Xeris Pharmaceuticals | 81 | 2018-01-23 | 2020-02-17 |
| Closed-Loop Glucagon Pump for Treatment of Post-Bariatric Hypoglycemia glucagon, Closed loop glucagon pump - Post-bariatric Hypoglycemia | Phase 1 / Phase 2 | Completed | Joslin Diabetes Center | 18 | 2017-09-19 | 2022-09-06 |
| Glucose Response of G-Pen (Glucagon Injection) in Pediatric T1D Patients Glucagon - Diabetes Mellitus, Type 1 | Phase 3 | Completed | Xeris Pharmaceuticals | 31 | 2017-03-27 | 2018-12-11 |
| Safety and Efficacy of G-Pen Compared to Lilly Glucagon for Hypoglycemia Rescue in Adult Type 1 Diabetics G-Pen (glucagon injection), Lilly Glucagon (glucagon injection [rDNA origin]) - Hypoglycemia, Diabetes Mellitus, Type 1 | Phase 3 | Completed | Xeris Pharmaceuticals | 80 | 2017-03-15 | 2018-10-30 |
| CSI-Glucagon for Prevention of Hypoglycemia in Children With Congenital Hyperinsulinism Glucagon, Placebo - Congenital Hyperinsulinism | Phase 2 | Completed | Xeris Pharmaceuticals | 5 | 2016-10-01 | 2019-12-10 |
| Delivery of G-Pump™ (Glucagon Infusion) From an OmniPod® to Prevent Hypoglycemia in Post-Bariatric Surgery Patients G-Pump™ (glucagon infusion) - Hypoglycemia, Complications of Bariatric Procedures | Phase 2 | Completed | Xeris Pharmaceuticals | 8 | 2016-03-01 | 2018-10-30 |
| The Use of Mini-dose Glucagon to Prevent Exercise-induced Hypoglycemia in Type 1 Diabetes G-Pen Mini™ (glucagon injection), Glucose Tabs, Basal Insulin Reduction - Diabetes Mellitus, Type 1 | Phase 2 | Completed | Jaeb Center for Health Research | 16 | 2016-01-01 | 2020-03-03 |
| Mini-Dose Glucagon to Treat Non-Severe Hypoglycemia G-Pen Mini™ (glucagon injection), Glucose Tablets - Diabetes Mellitus, Type 1 | Phase 2 | Completed | Jaeb Center for Health Research | 26 | 2015-09-01 | 2020-03-03 |
| G-Pen™ for Hypoglycemia Rescue in T1D Patients Glucagon - Hypoglycemia | Phase 2 | Completed | Xeris Pharmaceuticals | 7 | 2015-04-01 | 2017-07-07 |
| Safety and Efficacy Study of Mini-Dose Glucagon (G-Pen Mini) in Patients With Type 1 Diabetes G-Pen Mini™ (glucagon injection) - Hypoglycemia | Phase 2 | Completed | Xeris Pharmaceuticals | 13 | 2014-03-01 | 2018-04-05 |
| PK/PD Study With G-Pump (Glucagon Infusion) in T1DM Patients Novo Nordisk GlucaGen®, G-Pump™ (glucagon infusion) - Hypoglycemia | Phase 2 | Completed | Xeris Pharmaceuticals | 19 | 2014-03-01 | 2018-04-06 |
| Safety, Tolerability, Pharmacokinetic (PK) and Pharmacodynamic (PD) Study of G-Pen(TM) (Glucagon Injection) to Treat Severe Hypoglycemia G-Pen(TM) 1 mg, Lilly Glucagon(TM) 1 mg, G-Pen(TM) 0.5 mg - Hypoglycemia | Phase 2 | Completed | Xeris Pharmaceuticals | 30 | 2013-10-01 | 2016-02-03 |
Hypoglycemia (11) · Diabetes Mellitus, Type 1 (8) · Motor Activity (3) · Congenital Hyperinsulinism (2) · Diabetes Mellitus (1) · Glucose Metabolism Disorders (1) · Hypothyroidism (1) · Insulin Resistance (1)
Glucagon (13) · Glucose (1) · Insulin (1) · Thyroxine (1) · pramlintide (1)
United States (18) · Canada (4) · Austria (1)
Jessica Castle, MD (2) · Morey W Haymond, MD (2) · Andrea Valasquez (1) · George Atiee (1) · Howard Wolpert, M.D. (1) · Khaled Junaidi, MD (1) · Mary E Patti, MD (1) · Michael Rickels, M.D., M.S. (1) · Michael Riddell, PhD (1) · Ralph A DeFronzo, MD (1) · Stephanie DuBose, M.P.H (1) · Stephanie N DuBose, MPH (1) · Valentina Conoscenti, MD (1)
PMID 34620618, PMID 26861921, PMID 28591776, PMID 29355439, PMID 29776987, PMID 32907828, PMID 35322535, PMID 36689626
R44DK107114 (2), R44DK085809 (1), R44DK096706 (1), R44DK096715 (1), R44DK105691 (1)