4 completed, 1 active not recruiting, 1 recruiting, 1 withdrawn. 6 Phase 1, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 6 | Completed 3, Active not recruiting 1, Recruiting 1, Withdrawn 1 |
| Phase 2 | 1 | Active not recruiting 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| An Open Label Dose Escalation Study of VY1706 in Participants With Early Alzheimer's Disease VY1706 Low dose, VY1706 Mid dose, VY1706 High Dose - Alzheimer s Disease | Phase 1 | Recruiting | Voyager Therapeutics | 18 | 2026-09-03 | 2026-09-04 |
| VY7523-102: Randomized, Placebo-Controlled, Double-Blind, Multiple Ascending Dose Study in Participants With Early Alzheimer's Disease VY7523, Placebo Comparator - Alzheimer's Disease (AD) | Phase 1 / Phase 2 | Active not recruiting | Voyager Therapeutics | 52 | 2025-03-03 | 2026-10-23 |
| Safety and Tolerability Study With VY-HTT01, in Adults With Early Manifesting Huntington's Disease Intraparenchymal rAAV1 - (mi)RNA HTT - Huntington Disease | Phase 1 | Withdrawn | Voyager Therapeutics | 2021-07-30 | 2021-08-16 | |
| VY-AADC02 for Parkinson's Disease With Motor Fluctuations (RESTORE-1) VY-AADC02, Sham (Placebo) Surgery - Parkinson's Disease | Phase 1 | Completed | Neurocrine Biosciences | 14 | 2018-10-17 | 2024-12-10 |
| Observational, Long-term Extension Study for Participants of Prior VY-AADC01 Studies Parkinson's Disease | Completed | Neurocrine Biosciences | 14 | 2018-08-24 | 2023-12-22 | |
| Safety and Efficacy Study of VY-AADC01 for Advanced Parkinson's Disease VY-AADC01 - Idiopathic Parkinson's Disease, Parkinson's Disease | Phase 1 | Completed | Neurocrine Biosciences | 16 | 2017-05-11 | 2022-03-21 |
| Safety Study of AADC Gene Therapy (VY-AADC01) for Parkinson's Disease VY-AADC01 - Parkinson's Disease | Phase 1 | Completed | Neurocrine Biosciences | 15 | 2013-10-01 | 2020-03-03 |
Parkinson Disease (4) · Basal Ganglia Diseases (1) · Brain Diseases (1) · Central Nervous System Diseases (1) · Huntington Disease (1) · Movement Disorders (1) · Nervous System Diseases (1) · Neurodegenerative Diseases (1) · Parkinsonian Disorders (1)
Biological Assay (1) · Surgical Procedures, Operative (1) · salicylhydroxamic acid (1)
United States (6) · Canada (1)
Steve Hersch, MD (2)