2 active not recruiting, 1 recruiting, 1 terminated. 4 Phase 2, 2 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 4 | Active not recruiting 2, Recruiting 1, Terminated 1 |
| Phase 1 | 2 | Active not recruiting 1, Recruiting 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study to Evaluate the Safety and Efficacy of Mesothelin-Targeting Logic-gated CAR T, in Participants With Solid Tumors That Express MSLN and Have Lost HLA-A*02 Expression A2B694, A2B543, xT CDx with HLA-LOH Assay - Solid Tumor, Adult, Colorectal Cancer | Phase 1 / Phase 2 | Recruiting | A2 Biotherapeutics Inc. | 474 | 2024-04-03 | 2026-06-12 |
| A Study to Evaluate the Safety and Efficacy of A2B530, a Logic-gated CAR T, in Participants With Solid Tumors That Express CEA and Have Lost HLA-A*02 Expression A2B530, xT-Onco with HLA-LOH Assay - Solid Tumor, Adult, Solid Tumor | Phase 1 / Phase 2 | Active not recruiting | A2 Biotherapeutics Inc. | 160 | 2023-04-28 | 2025-04-25 |
| Niraparib in the Treatment of Patients With Advanced PALB2 Mutated Tumors Niraparib - Solid Tumor, Breast Tumor | Phase 2 | Terminated | Tempus AI | 22 | 2022-03-15 | 2025-10-29 |
| Initiative for Molecular Profiling and Advanced Cancer Therapy (IMPACT II) Targeted Therapy Based on Molecular Profiling, Standard-of-Care Therapy - Metastatic Malignant Neoplasm, Recurrent Malignant Neoplasm | Phase 2 | Active not recruiting | M.D. Anderson Cancer Center | 1362 | 2014-05-13 | 2026-08-10 |
Pancreatic Neoplasms (3) · Recurrence (3) · Carcinoma, Non-Small-Cell Lung (2) · Colonic Neoplasms (2) · Colorectal Neoplasms (2) · Lung Neoplasms (2) · Neoplasm Metastasis (2) · Neoplasms (2) · Breast Neoplasms (1) · Endometrial Neoplasms (1) · Esophageal Neoplasms (1) · Head and Neck Neoplasms (1) · Melanoma (1) · Mesothelioma (1) · Mesothelioma, Malignant (1)
niraparib (1)
United States (4)
Apostolia M Tsimberidou (1) · Eric Ng, MD (1) · John Welch, MD, PhD (1) · Virginia Rhodes (1)