6 completed, 3 recruiting, 2 unknown, 1 not yet recruiting. 5 Not applicable, 2 Phase 2, 1 Phase 3, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 5 | Completed 3, Not yet recruiting 1, Recruiting 1 |
| Phase 2 | 2 | Recruiting 2 |
| Phase 3 | 1 | Recruiting 1 |
| Phase 4 | 1 | Completed 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| SCAF-TB - Saving Children and Their Families From Tuberculosis: Implementation Research to Improve TB Preventive Treatment Initiation and Completion Rates Among Contact Persons in Tajikistan and Tanzania CY-TB Patch, Audiblehealth DX - Tuberculosis Infection, Latent, Tuberculosis Active | Not applicable | Not yet recruiting | KNCV Tuberculosis Foundation | 880 | 2026-06-01 | 2026-07-20 |
| Introduction of Dispersible 3HP Formulations for TB Preventive Treatment in Children: a Multi-country Evaluation TB - Tuberculosis, Household Contact | Unknown | The Aurum Institute NPC | 1200 | 2024-08-01 | 2024-07-19 | |
| Platform Assessing Regimens and Durations In a Global Multisite Consortium for TB Ganfeborole, BTZ-043, Bedaquiline (B) - Pulmonary Tuberculosis | Phase 2 | Recruiting | University College, London | 2500 | 2024-01-09 | 2026-10-15 |
| Assessing Diagnostics At Point-of-care for Tuberculosis Tongue swab-based molecular assays - Tuberculosis | Not applicable | Recruiting | University of California, San Francisco | 1350 | 2023-08-28 | 2026-09-02 |
| DeMONSTRATE-TB Study in Ethiopia Enhanced community-wide TB intervention, Routine TB program activities - Reducing Tuberculosis Incidence | Phase 2 / Phase 3 | Recruiting | Management Sciences for Health | 131438 | 2023-02-27 | 2024-12-05 |
| Triage Test for All Oral DR-TB Regimen (TRiAD Study) Xpert® MTB/XDR - Drug Resistant Tuberculosis, MDR-TB | Completed | Centre for the AIDS Programme of Research in South Africa | 786 | 2022-05-26 | 2025-06-26 | |
| Evaluation of a Rapid Point-of-Care Serological Triage Test for Active TB SeroSelectTB rapid TB test - Tuberculosis, Pulmonary | Not applicable | Completed | Norwegian Institute of Public Health | 9097 | 2021-09-21 | 2026-03-12 |
| Community Initiated Preventive Therapy for TB Community-Based TPT Initiation - Tuberculosis | Not applicable | Completed | Johns Hopkins University | 1168 | 2021-09-07 | 2023-08-14 |
| Qualitative Understanding of Community TB Services Pre and Post the CHIP-TB Trial Tuberculosis Infection, Tuberculosis Prevention | Completed | Johns Hopkins University | 183 | 2021-06-04 | 2023-07-12 | |
| Choice Architecture Based TB Preventive Therapy Prescribing Choice Architecture - HIV/AIDS, Tuberculosis | Not applicable | Completed | Johns Hopkins University | 57 | 2021-03-29 | 2025-08-12 |
| TB Reduction Through ART and TB Screening Project Combination of TB/HIV prevention activities (arm A), Combination of TB/HIV prevention activities (arm B), Standard of care (arm C) - Tuberculosis, HIV/AIDS | Unknown | London School of Hygiene and Tropical Medicine | 4200 | 2018-06-12 | 2021-02-25 | |
| Feasibility and Effectiveness of Community Based Isoniazid Preventive Therapy in Kenya community IPT - Tuberculosis | Phase 4 | Completed | KNCV Tuberculosis Foundation | 1259 | 2009-04-01 | 2013-05-20 |
Tuberculosis (8) · Latent Tuberculosis (3) · Acquired Immunodeficiency Syndrome (2) · Tuberculosis, Pulmonary (2) · Extensively Drug-Resistant Tuberculosis (1) · Tuberculosis, Multidrug-Resistant (1)
2-(2-methyl-1,4-dioxa-8-azaspiro(4.5)dec-8-yl)-8-nitro-6-(trifluoromethyl)-4H-1,3-benzothiazin-4-one (1) · Ethambutol (1) · Fumigant 93 (1) · GSK656 (1) · Isoniazid (1) · Linezolid (1) · Moxifloxacin (1) · OPC-67683 (1) · Protons (1) · Pyrazinamide (1) · Rifampin (1) · Standard of Care (1) · bedaquiline (1) · delpazolid (1) · pretomanid (1)
Ethiopia (5) · South Africa (5) · Tanzania (3) · Nigeria (2) · Zambia (2) · Kenya (1) · Malawi (1) · Moldova (1) · Mozambique (1) · Philippines (1) · Tajikistan (1) · Uganda (1) · Vietnam (1) · Zimbabwe (1)
Nicole Salazar-Austin, MD (2) · Adithya Cattamanchi (1) · Balthazar Nyombi, PhD (1) · Carol Holm-Hansen, PhD (1) · Christopher Hoffmann, MD, MPH (1) · Eveline Klinkenberg, PhD (1) · Grant Theron, PhD (1) · Helen Ayles, Professor (1) · Jeremy M Chakaya, MD (1) · Jonathan Golub, PhD, MPH (1) · Kidist Bobosha, PhD (1) · Kogieleum Naidoo, MBCHB, PHD (1)
PMID 39252005, PMID 35710250, PMID 35820917, PMID 35854324, PMID 37491264, PMID 37682971, PMID 39609025, PMID 40305495, PMID 40376825, PMID 40412816, PMID 42054680, PMID 42078099, PMID 42766564