12 completed, 5 unknown, 4 active not recruiting, 4 terminated. 6 Not applicable, 3 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 6 | Not yet recruiting 2, Completed 1, Recruiting 1, Terminated 1, Withdrawn 1 |
| Phase 4 | 3 | Completed 2, Active not recruiting 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Molecular Evidence of Rejection Intervention Trial Prednisone, Placebo - Heart Transplant Rejection | Not applicable | Not yet recruiting | CareDx | 200 | 2027-03-01 | 2026-10-29 |
| Forecasting Relapse Outcomes With AlloHeme-based Risk Detection in Post-Allo-HCT AML/MDS Patients (FORWARD) AlloHeme - AML (Acute Myelogenous Leukemia), MDS (Myelodysplastic Syndrome) | Enrolling by invitation | CareDx | 400 | 2026-09-24 | 2026-10-16 | |
| Prospective Reduction Of Transplant Complications Through Enhanced Preservation Therapy to Prevent Primary Graft Dysfunction Xo Port Organ Preservation System, Standard of Care - Ice packs - Primary Graft Dysfunction | Not applicable | Recruiting | University Health Network, Toronto | 50 | 2026-04-17 | 2026-07-13 |
| HeartCare Immuno-optimization in Cardiac Allografts (MOSAIC) HeartCare - Heart Transplant, Immunosuppression | Not applicable | Not yet recruiting | CareDx | 930 | 2025-12-01 | 2024-10-23 |
| KidneyCare Immuno-optimization in Renal Allografts (KIRA) KidneyCare, steroid, MMF - Kidney Transplant, Immunosuppression | Not applicable | Withdrawn | CareDx | 2022-08-01 | 2023-03-27 | |
| AlloSure Lung Assessment and Metagenomics Outcomes Study Lung Transplant Infection, Lung Transplant; Complications | Active not recruiting | CareDx | 550 | 2021-10-29 | 2026-06-25 | |
| Technology Enabled And Molecular Monitoring of the Allograft and Transplant rEcipient Transplant | Terminated | CareDx | 246 | 2021-10-26 | 2023-08-30 | |
| Impact of Immunosuppression Adjustment on COVID-19 Vaccination Response in Kidney Transplant Recipients Reduction in antimetabolite immunosuppression - COVID-19, Immunosuppression | Phase 4 | Active not recruiting | University of California, Davis | 14 | 2021-09-24 | 2026-04-03 |
| Use of DNA Testing to Help Transition Kidney Transplant Recipients to Belatacept-only Immunosuppression Belatacept - Kidney Transplant Immunosuppression | Phase 4 | Completed | University of Texas Southwestern Medical Center | 25 | 2021-07-28 | 2026-08-14 |
| Assessment of Chimerism and Relapse Post Bone Marrow/Hematopoietic Cell Transplant (HCT) Using AlloHeme Test Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia | Completed | CareDx | 307 | 2021-07-22 | 2026-10-16 | |
| Assessing Benchmarks For Allosure And Allomap Testing in Simultaneous Kidney & Pancreas Transplant Recipients. Allosure, AlloMap - Transplant; Complication, Rejection | Completed | Montefiore Medical Center | 41 | 2021-07-14 | 2026-07-06 | |
| Molecular Assessment and Profiling of Liver Transplant Recipients LiverCare - Liver Transplantation, Biomarkers | Active not recruiting | CareDx | 1500 | 2021-05-26 | 2026-09-03 | |
| Allosure in Simultaneous Pancreas Kidney Transplant DD-cfDNA - Kidney Pancreas Transplant | Terminated | Washington University School of Medicine | 13 | 2021-02-26 | 2024-08-07 | |
| Transition of Renal Patients Using AlloSure Into Community Kidney Care AlloSure - Kidney Transplant Rejection | Completed | CareDx | 248 | 2020-11-19 | 2023-11-03 | |
| The Integration of a Mobile App Platform With Biomarkers in Kidney Transplantation Smartphone App, Tailored education - Medication Compliance | Not applicable | Completed | Duke University | 22 | 2020-10-15 | 2022-02-17 |
| Personalization of Immunosuppressive Treatment for Organ Transplant Recipients AlloSure, PAXGene - Kidney Injury, Kidney Failure | Terminated | George Washington University | 105 | 2020-10-01 | 2024-02-26 | |
| Assessment of Donor Derived Cell Free DNA and Utility in Lung Transplantation Allosure - Lung Transplant Failure and Rejection | Not applicable | Terminated | Pablo Sanchez | 40 | 2020-06-29 | 2024-03-25 |
| AlloSure Guided Immuno-Optimization for COVID-19: An Early Experience Solid Organ Transplant Rejection, COVID-19 | Unknown | CareDx | 500 | 2020-04-01 | 2020-04-10 | |
| Longitudinal Study of Cell Free DNA in Lung Transplant Lung Transplant Rejection | Completed | University of Colorado, Denver | 24 | 2020-03-19 | 2022-11-02 | |
| Immune Monitoring to Facilitate Belatacept Monotherapy Allosure, Immunosuppression reduction, Trugraf - Kidney Transplant Rejection, Immunosuppression | Phase 4 | Completed | Massachusetts General Hospital | 17 | 2020-02-11 | 2023-12-04 |
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Rejection, Psychology (4) · COVID-19 (2) · Heart Diseases (2) · Leukemia, Myeloid, Acute (2) · Renal Insufficiency, Chronic (2) · Acute Kidney Injury (1) · Anemia, Refractory, with Excess of Blasts (1) · Kidney Diseases (1) · Kidney Failure, Chronic (1) · Medication Adherence (1) · Myelodysplastic Syndromes (1) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (1) · Primary Graft Dysfunction (1) · Recurrence (1) · Renal Insufficiency (1)
Abatacept (2) · Prednisone (2) · Standard of Care (2) · Everolimus (1) · Mycophenolic Acid (1) · Sirolimus (1) · Steroids (1)
United States (23) · Canada (2)
Kiran Khush, MD (2) · Alice L Gray, MD (1) · Ciara Shaver (1) · Cyrus Feizpour, MD (1) · David Wojciechowski, DO (1) · Debbie Levine (1) · Eileen Chambers, MD (1) · Enver Akalin, MD (1) · Hannah Gilligan, MD (1) · James P Yee (1) · James P Yee, MD, PhD (1) · James Yee, MD (1) · Kanish Mohib, PhD (1) · Nir Uriel, MD, MSc, FACC (1) · Nishant Dwivedi, MD/PhD (1)
PMID 33636851, PMID 34184326, PMID 37382155, PMID 41123513, PMID 42302101
K23DK122136 (1)