29 completed, 14 recruiting, 11 not yet recruiting, 8 active not recruiting. 69 Phase 1, 37 Phase 2.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study of AK157D1 for Injection in Advanced Solid Tumors AK157D1 for injection - Advanced Solid Tumors | Phase 1 | Recruiting | Akeso | 243 | 2026-09-30 | 2026-10-13 |
| A Study of AK138D1 Alone or in Combination With Ivonescimab in Advanced Non-Small Cell Lung Cancer AK138D1, Ivonescimab, Carboplatin - Non-Small Cell Lung Cancer | Phase 1 / Phase 2 | Recruiting | Akeso | 265 | 2026-07-07 | 2026-07-29 |
| A Study of AK138D1 Alone or in Combination With Ivonescimab in Advanced Breast Cancer AK138D1, Ivonescimab, treatment of physician's choice - Breast Cancer | Phase 1 / Phase 2 | Not yet recruiting | Akeso | 286 | 2026-06-06 | 2026-04-30 |
| A Study to Evaluate the PK Similarity of AK104 in Healthy Chinese Male Participations AK104 (New Site), AK104 (Original Site) - Healthy Male Adults Participants | Phase 1 | Not yet recruiting | Akeso | 158 | 2026-06-01 | 2026-06-01 |
| A Phase I Clinical Study of AK150 in Advanced Malignant Solid Tumor AK150 - Advanced Malignant Solid Tumors | Phase 1 | Not yet recruiting | Akeso | 96 | 2026-04-30 | 2026-05-05 |
| A Study of AK112 in Combination With VG2025 in Colorectal Cancer With Liver Metastases VG2025, AK112 - Colorectal Cancer With Hepatic Metastases | Phase 1 / Phase 2 | Not yet recruiting | Akeso | 72 | 2026-03-02 | 2026-01-21 |
| A Study to Evaluate the PK Similarity of AK112 in Healthy Chinese Male Subjects AK112 (New Site), AK112 (Original Site) - Healthy Male Subjects | Phase 1 | Active not recruiting | Akeso | 108 | 2025-12-11 | 2026-03-09 |
| A Clinical Trial of AK152 in Healthy Volunteers and Patients With Alzheimer' s Disease AK152, Placebo - Alzheimer' s Disease | Phase 1 | Not yet recruiting | Akeso | 108 | 2025-12-01 | 2025-12-24 |
| A Study of AK138D1 in Advanced Malignant Tumors AK138D1 - Solid Cancer | Phase 1 | Recruiting | Akeso | 200 | 2025-10-22 | 2025-12-15 |
| A Study Evaluating the Single Subcutaneous Injection of Ebronucimab in Healthy Male Chinese Subjects Ebronucimab - Healthy Subjects | Phase 1 | Completed | Akeso | 230 | 2025-10-20 | 2026-06-26 |
| A Study of AK146D1 for Injection in Advanced Solid Tumors AK146D1 for injection - Advanced Solid Tumors | Phase 1 | Recruiting | Akeso | 200 | 2025-08-07 | 2025-09-03 |
| A Study of mRNA Vaccines AK154 Monotherapy or in Combination With AK104/AK112,and Sequential mFOLFIRINOX in Surgically Resected PDAC AK154, Cadonilimab, Ivonescimab (SMT112 or AK112) Injection - Pancreas Cancer, Pancreas Cancer, Duct Cell Adenocarcinoma | Phase 1 | Not yet recruiting | Akeso | 60 | 2025-07-22 | 2025-04-06 |
| A Study of AK146D1 for Injection in the Treatment of Advanced Solid Tumors AK146D1 for injection - Advanced Solid Tumors | Phase 1 | Recruiting | Akeso | 48 | 2025-07-02 | 2025-07-17 |
| AK129 Combination Therapy for Advanced Solid Tumors AK129(dose 1), Pemetrexed, Paclitaxel - Non-small Cell Lung Cancer Stage IIIB/IV, Head and Neck Squamous Cell Carcinoma (HNSCC) | Phase 1 / Phase 2 | Recruiting | Akeso | 230 | 2025-05-21 | 2025-06-03 |
| A Clinical Study of AK139 in Healthy Subjects Placebo, AK111 - Healthy Subjects | Phase 1 | Not yet recruiting | Akeso | 48 | 2025-05-06 | 2025-04-27 |
| A Study of AK130 in Combination With AK112 for the Treatment of Advanced Biliary Tract Cancer AK112, AK130 - Biliary Tract Cancer | Phase 1 / Phase 2 | Recruiting | Akeso | 135 | 2025-04-30 | 2026-03-03 |
| AK135 in Patients With Chemotherapy-Induced Peripheral Neuropathy (CIPN) AK135 - Chemotherapy-induced Peripheral Neuropathy (CIPN) | Phase 1 | Not yet recruiting | Akeso | 85 | 2025-02-28 | 2025-03-06 |
| A Phase I Study of AK138D1 in the Treatment of Advanced Solid Tumors AK138D1 - Solid Cancer | Phase 1 | Recruiting | Akeso | 100 | 2025-02-24 | 2025-03-06 |
| AK112 and Cadonilimab Combined With Chemotherapy for 1L Treatment of Metastatic Pancreatic Cancer AK112, Cadonilimab, nab-paclitaxel, gemcitabine, AK112, nab-paclitaxel, gemcitabine, nab-paclitaxel, gemcitabine - Metastatic Pancreatic Ductal Adenocarcinoma | Phase 1 / Phase 2 | Active not recruiting | Akeso | 110 | 2025-01-21 | 2026-03-09 |
| A Study of AK129 With or Without AK117 in PD(L)1-refractory Classic Hodgkin Lymphoma AK129, AK117 - Classic Hodgkin Lymphoma | Phase 1 / Phase 2 | Recruiting | Akeso | 280 | 2025-01-17 | 2025-02-11 |
Showing 20 of 69. Sign in to see all of them.
Neoplasms (3) · Carcinoma, Hepatocellular (2) · Carcinoma, Non-Small-Cell Lung (2) · Leukemia, Myeloid, Acute (2) · Biliary Tract Neoplasms (1) · Breast Neoplasms (1) · Colitis, Ulcerative (1) · Colorectal Neoplasms (1) · Dermatitis, Atopic (1) · Diabetes Mellitus, Insulin-Dependent, 12 (1) · Hodgkin Disease (1) · Hypercholesterolemia (1) · Lung Neoplasms (1) · Lymphoma, T-Cell, Peripheral (1) · Melanoma (1)
Carboplatin (7) · Paclitaxel (5) · Fluorouracil (4) · Injections (4) · Pemetrexed (4) · Azacitidine (3) · Cisplatin (3) · Docetaxel (3) · Oxaliplatin (3) · Capecitabine (2) · Drug Therapy (2) · Gemcitabine (2) · Irinotecan (2) · 130-nm albumin-bound paclitaxel (1) · Cetuximab (1)
China (64) · Australia (5)
Jihui Hao, PhD (2) · Li Zhang, MD (2) · Nong Xu, MD (2) · Rui Chen, MD (2) · Wenting Li, MD (2) · Alex HL Wong, MMedSc (1) · Caicun Zhou, MD (1) · Depei Wu, MD (1) · Fei Ma (1) · Hongzhong Jin, MD (1) · Hui Gan (1) · Jianming Xu, MD (1) · Jie Wang, Doctor (1) · Jieer Ying, MD (1) · Jihui Hao, Doctor (1)
PMID 35833116, PMID 35165764, PMID 36566344, PMID 36569905, PMID 36989884, PMID 37677918, PMID 37879536, PMID 37942328, PMID 38110665, PMID 39490738, PMID 40114411, PMID 40297315, PMID 42409321