5 completed, 2 active not recruiting, 1 terminated, 1 withdrawn. 7 Phase 1, 2 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 7 | Completed 3, Active not recruiting 2, Terminated 1, Withdrawn 1 |
| Not applicable | 2 | Completed 2 |
Follow Trimethaphan: new trials by email Literature Review of Trimethaphan trials Research Report on Trimethaphan
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Autonomic Blockade and Endogenous Glucose Production Trimethaphan, Saline - Insulin Resistance | Phase 1 | Withdrawn | Vanderbilt University Medical Center | 2017-04-17 | 2021-06-08 | |
| Reduction in Splanchnic Capacitance Contributes to Sympathetically Dependent Hypertension in Autonomic Trimethaphan, Placebo - Multiple System Atrophy, Orthostatic Hypotension | Phase 1 | Active not recruiting | Vanderbilt University | 2 | 2016-04-01 | 2026-03-13 |
| Role of Sympathetic Activity and Splanchnic Capacitance in Hypertension Trimethaphan, Nitroglycerin - Hypertension | Phase 1 | Active not recruiting | Vanderbilt University | 12 | 2015-04-01 | 2026-08-27 |
| Cardiovascular Effects of Angiotensin (1-7) in Essential Hypertension Angiotensin (1-7), Trimethaphan, Phenylephrine - Hypertension, Hypertension, Essential | Phase 1 | Terminated | Vanderbilt University | 24 | 2015-01-01 | 2024-01-09 |
| Autonomic Nervous System and Nitric Oxide Interactions Trimethaphan, Placebo - Endothelial Dysfunction | Phase 1 | Completed | Vanderbilt University | 21 | 2010-06-01 | 2018-02-28 |
| Pathophysiology of Cardiometabolic Risk Factors in African Americans L-NMMA, Trimethaphan - Obesity, Hypertension | Phase 1 | Completed | Vanderbilt University Medical Center | 34 | 2010-01-01 | 2017-01-18 |
| The Autonomic Nervous System and the Metabolic Syndrome Blocked, Intact - Obesity | Not applicable | Completed | Vanderbilt University | 56 | 2008-08-01 | 2016-08-05 |
| The Autonomic Nervous System and Obesity Trimethaphan, Pseudoephedrine - OBESITY, HYPERTENSION | Phase 1 | Completed | Vanderbilt University | 128 | 2003-04-01 | 2018-03-01 |
| Nitric Oxide and the Autonomic Nervous System L-NMMA, Trimethaphan - Hypertension, Pure Autonomic Failure | Not applicable | Completed | Vanderbilt University | 112 | 2002-08-01 | 2013-06-04 |
Hypertension (6) · Obesity (3) · Pure Autonomic Failure (2) · Essential Hypertension (1) · Hypotension, Orthostatic (1) · Insulin Resistance (1) · Multiple System Atrophy (1) · Shy-Drager Syndrome (1)
Vanderbilt University (7) · Vanderbilt University Medical Center (2)
United States (9)
Italo Biaggioni, M.D. (3) · Italo Biaggioni, MD (3) · Cyndya Shibao, MD (1)
PMID 17116758, PMID 17130304, PMID 18426998, PMID 22469621, PMID 34729682, PMID 39090323
K23HL103976 (1)