27 completed, 5 not yet recruiting, 4 recruiting, 2 terminated. 34 Not applicable, 5 Phase 2, 3 Phase 1, 1 Phase 4.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Glycemic Impact of NNS Via the Gut Microbiome Sucralose - Prediabetes | Not applicable | Enrolling by invitation | Tufts University | 10 | 2026-10-01 | 2026-10-09 |
| Impact of Sweeteners on the Addictive Threshold of Nicotine Nicotine 0.05 mg/pulse and 0.1 mg/pulse, Saline Placebo (0.5mL injection), sucralose - Smoking ( Cigarette) | Phase 1 | Not yet recruiting | Yale University | 36 | 2026-09-01 | 2026-08-31 |
| SucroMet Nutritional Intervention Trial Sucrose- Low dose, Sucrose - High Dose, Sucralose - Low Dose - Overweight , Obesity, Glucose Metabolism | Not applicable | Recruiting | Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud | 120 | 2026-07-01 | 2026-06-18 |
| Short-Term Effects of Sucralose and Saccharin on Blood Sugar and Gut Microbiota in Type 2 Diabetes Sucralose, Saccharin, Placebo (Calcium Carbonate) - Type 2 Diabetes Mellitus (T2DM) | Not applicable | Not yet recruiting | National University of Malaysia | 33 | 2026-01-30 | 2025-12-10 |
| Effects of Sweetener Consumption on Risk Factors for Heart Disease in Prediabetic Subjects Saccharin, Sucralose, Erythritol - Prediabetic State, Metabolic Syndrome | Not applicable | Not yet recruiting | Charite University, Berlin, Germany | 80 | 2026-01-05 | 2026-01-29 |
| the Effect of Monk Fruit and Splenda on Salivary Ph and Streptococcus Mutans Count in Vivo Study Monk fruit sweetener mouth rinse, Splenda (sucralose) sweetener mouth rinse, Sucrose mouth rinse - Caries Active | Not applicable | Not yet recruiting | Al-Mustansiriyah University | 90 | 2025-10-01 | 2025-09-24 |
| Sucralose as a Way to Enhance Regulatory T Cells sucralose, Placebo - Healthy Volunteer | Not applicable | Not yet recruiting | Caroline Lamarche | 10 | 2025-09-01 | 2025-06-05 |
| Effect of Within-Meal Consumption of Allulose on Diet-induced Thermogenesis Allulose, Stevia, Sucralose - Diet Induced Thermogenesis | Not applicable | Completed | Toronto Metropolitan University | 12 | 2025-05-06 | 2025-11-17 |
| Non-nutritive Sweeteners in Inflammatory Bowel Disease Sucralose (non-nutritive sweetener) - Inflamatory Bowel Disease, Crohn Disease (CD) | Not applicable | Recruiting | University Hospitals Cleveland Medical Center | 40 | 2025-02-03 | 2026-09-25 |
| Investigating the Effect of the Non-nutritive Sweetener Sucralose in Inflammatory Bowel Disease Sucralose (non-nutritive sweetener) - Inflamatory Bowel Disease, Crohn Disease (CD) | Not applicable | Recruiting | Case Western Reserve University | 40 | 2024-04-18 | 2026-10-01 |
| Effects of Sucralose in Gut Intestinal Microbiota and Postprandial GLP-1 sucralose, placebo - GLP-1, Gut Microbiota | Not applicable | Completed | Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran | 40 | 2023-06-01 | 2025-04-04 |
| Brain and Glycemic Responses to Sweet Soft Drinks Water (reference), Sucrose, Sucralose - Normal Physiological Response to Sweet Drinks | Not applicable | Completed | Wageningen University | 35 | 2023-01-09 | 2024-04-01 |
| Acute Impact of Non-Sugar Sweeteners (Sucralose and Aspartame) non-sugar sweeteners - Sucralose, non-sugar sweetener - aspartame, Non-sugar sweetener - control - Prediabetes | Not applicable | Completed | Virginia Polytechnic Institute and State University | 14 | 2022-08-01 | 2026-04-01 |
| Assessment of Reward Responses to Erythritol Using Flavor Preference Learning Erythritol, Sucrose, Sucralose - Reward Responses, Gastrointestinal Hormones | Not applicable | Completed | University Hospital, Basel, Switzerland | 20 | 2022-03-17 | 2022-10-12 |
| Effects of Oral Pre-loads on Subsequent Energy Intake Erythritol, Sucrose, Sucralose - Energy Intake, Gastrointestinal Hormones | Not applicable | Completed | University Hospital, Basel, Switzerland | 20 | 2021-02-05 | 2021-12-16 |
| Artificial Sweeteners in Breast Milk Artificial sweeteners (acesulfame-potassium, sucralose, saccharine, cyclamate) - Breastfeeding, Diabetes Mellitus | Not applicable | Completed | University of Aarhus | 49 | 2020-11-01 | 2022-11-02 |
| Effects of Artificial Sweeteners on Glucose Metabolism in Patients With Type 2 Diabetes sucralose - Diabetes Mellitus, Type 2 | Not applicable | Unknown | RenJi Hospital | 120 | 2019-12-01 | 2019-12-04 |
| Effects of Sucralose in Insulin Sensitivity Sucralose, Placebo - Insulin Sensitivity/Resistance | Not applicable | Completed | Paloma Almeda-Valdés | 24 | 2019-11-01 | 2023-10-19 |
| Effect of the Administration of L-Carnitine on Body Weight in Women in Crossfit Training L-Carnitine, Sucralose - Body Weight Changes | Phase 2 | Unknown | University of Guadalajara | 24 | 2018-12-17 | 2018-02-20 |
| Effects of Sucralose on Drug Absorption and Metabolism (The SweetMeds Study) Sucralose, Placebo - Healthy Volunteers, Overweight | Phase 2 | Recruiting | National Institute on Alcohol Abuse and Alcoholism (NIAAA) | 150 | 2018-04-05 | 2026-10-29 |
Showing 20 of 42. Sign in to see all of them.
Insulin Resistance (10) · Obesity (6) · Diabetes Mellitus, Type 2 (5) · Overweight (4) · Prediabetic State (3) · Crohn Disease (2) · Diabetes Mellitus (2) · Glucose Intolerance (2) · Infections (2) · Inflammatory Bowel Diseases (2) · Alcoholism (1) · Body Weight (1) · Body Weight Changes (1) · Breast Feeding (1) · Burns (1)
Yale University (5) · Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran (2) · Toronto Metropolitan University (2) · Unilever R&D (2) · University Hospital, Basel, Switzerland (2) · University of Wisconsin, Madison (2) · Al-Mustansiriyah University (1) · Caroline Lamarche (1) · Case Western Reserve University (1) · Charite University, Berlin, Germany (1) · Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud (1) · GlaxoSmithKline (1) · Hospital General de México Dr. Eduardo Liceaga (1) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (1) · National Institute on Alcohol Abuse and Alcoholism (NIAAA) (1)
United States (18) · Mexico (4) · Canada (3) · Netherlands (3) · Switzerland (2) · China (1) · Denmark (1) · Iraq (1) · Israel (1) · Malaysia (1) · Spain (1) · Thailand (1) · United Kingdom (1)
Anne Christin Meyer-Gerspach, PD, PhD (2) · Dana M Small (2) · Paloma Almeda-Valdes, MD, PhD (2) · Abigail Raffner, RD PhD (1) · Abigal Raffner, PhD, RD (1) · Andrea C King, PhD (1) · Chutintorn Sriphrapradang, M.D. (1) · Dana M Small, PhD (1) · Eran Elinav (1) · Evan S Dellon, MD, MPH (1) · Fabio Cominelli, MD PhD (1) · Fabio Cominelli, MD, PhD (1) · Guillermo Melendez, MD, MSc (1)
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P30DK020579 (1), R01AA013746 (1), R01DK101856 (1), R37DK020495 (1), U54DA036151 (1)