14 completed, 3 terminated, 2 recruiting. 9 Phase 2, 7 Phase 1, 6 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 9 | Completed 5, Recruiting 2, Terminated 2 |
| Phase 1 | 7 | Completed 5, Recruiting 1, Terminated 1 |
| Phase 3 | 6 | Completed 4, Recruiting 1, Terminated 1 |
Follow Tirapazamine: new trials by email Literature Review of Tirapazamine trials Research Report on Tirapazamine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Phase II/III Trial Comparing Transarterial Tirapazamine Embolization (TATE) With cTACE for Intermediate-stage Liver Cancer. tirapazamine, Transarterial Embolization (TAE), TACE - HCC | Phase 2 / Phase 3 | Recruiting | Zhejiang Raygene Pharmaceuticals Co., Ltd | 300 | 2025-03-27 | 2025-04-06 |
| Evaluate the Effect of Tirazamine on Primary Liver Cancer. tirapazamine, Transarterial Embolization, TACE - Hepato Cellular Carcinoma (HCC) | Phase 1 / Phase 2 | Terminated | Zhejiang Raygene Pharmaceuticals Co., Ltd | 16 | 2021-05-14 | 2025-02-27 |
| TATE Versus TACE in Intermediate Stage HCC Tirapazamine, Doxorubicin - Carcinoma, Hepatocellular | Phase 2 | Terminated | Teclison Ltd. | 6 | 2017-12-05 | 2024-11-22 |
| Dose-defining Study of Tirapazamine Combined With Embolization in Liver Cancer Tirapazamine, Conventional Transarterial Embolization (TAE) - Hepatocellular Carcinoma, Gastrointestinal Cancer Metastatic | Phase 1 / Phase 2 | Recruiting | Teclison Ltd. | 25 | 2014-09-01 | 2026-04-20 |
| Cisplatin and Radiation Therapy With or Without Tirapazamine in Treating Patients With Cervical Cancer cisplatin, tirapazamine - Cervical Adenocarcinoma, Cervical Adenosquamous Cell Carcinoma | Phase 3 | Terminated | National Cancer Institute (NCI) | 402 | 2006-02-01 | 2019-07-23 |
| TRACE: Tirapazamine-Radiation And Cisplatin Evaluation Tirapazamine, Cisplatin - Head and Neck Squamous Cell Carcinoma | Phase 3 | Completed | Sanofi | 317 | 2005-04-01 | 2016-05-26 |
| Tirapazamine, Cisplatin, and Radiation Therapy in Treating Patients With Stage IB, Stage II, Stage III, or Stage IVA Cervical Cancer cisplatin, tirapazamine, brachytherapy - Cervical Cancer | Phase 1 | Completed | Peter MacCallum Cancer Centre, Australia | 22 | 2004-12-01 | 2013-06-26 |
| Tirapazamine Combined With Chemo and RT in Limited-Stage Small Cell Lung Cancer tirapazamine, cisplatin, etoposide - Limited Stage Small Cell Lung Cancer | Phase 2 | Completed | National Cancer Institute (NCI) | 72 | 2003-09-01 | 2014-05-15 |
| Concomitant Radiation and Cisplatin With and Without Tirapazamine in Treatment of Advanced Head and Neck Cancer tirapazamine (SR259075), cisplatin, Radiation Therapy - Head and Neck Neoplasms | Phase 3 | Completed | Sanofi | 861 | 2002-10-01 | 2010-02-15 |
| Chemotherapy, Tirapazamine, and Radiation Therapy in Treating Patients With Non-Small Cell Lung Cancer carboplatin, paclitaxel, tirapazamine - Lung Cancer | Phase 1 | Completed | California Cancer Consortium | 30 | 2002-03-01 | 2009-02-09 |
| Comparison of Chemotherapy Regimens in Treating Children With Relapsed or Progressive Rhabdomyosarcoma vincristine sulfate, irinotecan hydrochloride, cyclophosphamide - Alveolar Childhood Rhabdomyosarcoma, Embryonal Childhood Rhabdomyosarcoma | Phase 2 | Completed | National Cancer Institute (NCI) | 150 | 2001-11-01 | 2013-01-17 |
| Tirapazamine Plus Cisplatin in Treating Patients With Persistent or Recurrent Ovarian Epithelial or Primary Peritoneal Cancer cisplatin, tirapazamine - Ovarian Cancer, Primary Peritoneal Cavity Cancer | Phase 2 | Completed | Gynecologic Oncology Group | 2001-06-01 | 2012-01-10 | |
| Combination Chemotherapy With or Without Tirapazamine in Treating Patients With Stage IIIB or Stage IV Non-small Cell Lung Cancer carboplatin, paclitaxel, tirapazamine - Lung Cancer | Phase 3 | Completed | SWOG Cancer Research Network | 2000-11-01 | 2013-06-24 | |
| S0004: Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Limited-stage Small Cell Lung Cancer cisplatin, etoposide, tirapazamine - Lung Cancer | Phase 1 | Completed | SWOG Cancer Research Network | 30 | 2000-10-01 | 2012-10-04 |
| Cisplatin Plus Vinorelbine With or Without Tirapazamine in Treating Patients With Stage IIIB or Stage IV Non-Small Cell Lung Cancer cisplatin, tirapazamine, vinorelbine tartrate - Lung Cancer | Phase 3 | Completed | Sanofi | 2000-07-01 | 2013-08-02 | |
| Tirapazamine, Carboplatin, and Paclitaxel in Treating Patients With Advanced Malignant Solid Tumors carboplatin, paclitaxel, tirapazamine - Unspecified Adult Solid Tumor, Protocol Specific | Phase 1 | Completed | City of Hope Medical Center | 44 | 2000-03-01 | 2015-06-08 |
| Tirapazamine Plus Cyclophosphamide in Treating Children With Refractory Solid Tumors filgrastim, cyclophosphamide, tirapazamine - Unspecified Childhood Solid Tumor, Protocol Specific | Phase 1 | Completed | National Cancer Institute (NCI) | 12 | 1998-08-01 | 2013-02-05 |
| S9717 Tirapazamine Plus Cisplatin in Treating Patients With Metastatic, Recurrent, or Refractory Cervical Cancer cisplatin, tirapazamine - Cervical Cancer | Phase 2 | Completed | SWOG Cancer Research Network | 56 | 1998-08-01 | 2012-06-14 |
| Radiation Therapy and Combination Chemotherapy in Treating Patients With Stage III or Stage IV Head and Neck Cancer Tirapazamine, Cisplatin, 5-fluorouracil - Squamous Neck Carcinoma of the Head and Neck Cancer (SCCHN) | Phase 2 | Completed | Stanford University | 63 | 1996-06-01 | 2014-06-20 |
Lung Neoplasms (4) · Carcinoma, Hepatocellular (3) · Carcinoma, Non-Small-Cell Lung (3) · Head and Neck Neoplasms (3) · Uterine Cervical Neoplasms (3) · Adenocarcinoma of Lung (2) · Carcinoma, Ovarian Epithelial (1) · Carcinoma, Squamous Cell (1) · Hypoxia (1) · Laryngeal Diseases (1) · Neuroendocrine Tumors (1) · Ovarian Neoplasms (1) · Recurrence (1) · Squamous Cell Carcinoma of Head and Neck (1)
National Cancer Institute (NCI) (4) · SWOG Cancer Research Network (3) · Sanofi (3) · Teclison Ltd. (2) · Zhejiang Raygene Pharmaceuticals Co., Ltd (2) · California Cancer Consortium (1) · City of Hope Medical Center (1) · Gynecologic Oncology Group (1) · Peter MacCallum Cancer Centre, Australia (1) · Stanford University (1)
United States (16) · Canada (5) · Australia (3) · China (2) · Argentina (1) · Chile (1) · France (1) · Germany (1) · Hong Kong (1) · Hungary (1) · Italy (1) · New Zealand (1) · Poland (1) · Singapore (1) · South Africa (1)
Allan Covens, MD (1) · Caifang Ni, M.D (1) · Danny Rischin, MD (1) · Derick H. Lau, MD (1) · Elwyn Y. Loh, MD (1) · Gaojun Teng, M.D (1) · Harlan A. Pinto, MD (1) · Harriet O. Smith, MD (1) · Jiansong Ji, M.D (1) · Michael Soulen, MD (1) · Nadine Abi-Jaoudeh (1) · Paul DiSilvestro (1) · Philip Breitfeld (1) · Quynh-Thu Le (1)
PMID 14555506, PMID 15251940, PMID 15328179, PMID 16249022, PMID 16361616, PMID 16445649, PMID 16532436, PMID 18779603, PMID 24395863, PMID 27209505
U10CA032102 (3), P30CA033572 (1), U01CA062505 (1), U10CA027469 (1), U10CA098543 (1)