20 completed, 19 recruiting, 13 not yet recruiting, 4 active not recruiting. 54 Not applicable, 5 Phase 2, 2 Early Phase 1, 2 Phase 1, 1 Phase 3.
Follow taVNS: new trials by email Literature Review of taVNS trials Research Report on taVNS
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Probing Gut-Brain Communication in Parkinson's Disease taVNS, Sham taVNS - Parkinson Disease (PD) | Not applicable | Not yet recruiting | Spaulding Rehabilitation Hospital | 45 | 2027-01-01 | 2026-10-08 |
| Effects of Ultrasound-Guided Stellate Ganglion Block and Transcutaneous Auricular Vagus Nerve Stimulation on Sleep Quality After Radical Mastectomy for Breast Cancer SGB, taVNS - Sleep Disorder (Disorder) | Not applicable | Not yet recruiting | Affiliated Hospital of Jiaxing University | 136 | 2026-12-01 | 2026-09-29 |
| Effects of Adding Vagal Neuromodulation to Manual Therapy in Women With Fibromyalgia Transcutaneous Auricular Vagus Nerve Stimulation (taVNS), Sham Transcutaneous Auricular Vagus Nerve Stimulation (Sham taVNS), Manual Therapy Program - Fibromyalgia (FM) OR Fibromyalgia Syndrome, Manuel Therapy | Not applicable | Not yet recruiting | Hasan Kalyoncu University | 44 | 2026-11-02 | 2026-10-26 |
| Transcutaneous Auricular Vagus Nerve Stimulation to Improve Upper Extremity Recovery After Traumatic Brain Injury taVNS, FTP - Traumatic Brain Injury, Upper Extremity | Not applicable | Not yet recruiting | Craig Hospital | 30 | 2026-11-01 | 2026-10-19 |
| Pilot Testing of Vagus Nerve Stimulation for Early Spinal Cord Injury Recovery Transauricular vagus nerve stimulation - Spinal Cord Injuries (Complete and Incomplete) | Phase 1 / Phase 2 | Not yet recruiting | University of Alabama at Birmingham | 50 | 2026-11-01 | 2026-08-05 |
| Stimulating Your Nervous System for Calm (SYNC) Study taVNS, Mindfulness Meditation, low intensity taVNS - No Condition | Not applicable | Not yet recruiting | University of Houston | 50 | 2026-10-15 | 2026-10-16 |
| the Effect and Mechanism of Percutaneous Auricular Electrical Stimulation in Preventing Central Sensitization Pain in Patients With Rheumatoid Arthritis taVNS, Sham Stimulation - Rheumatoid Arthritis (RA), Transcutaneous Vagus Nerve Stimulation | Not applicable | Not yet recruiting | Guang'anmen Hospital of China Academy of Chinese Medical Sciences | 124 | 2026-10-01 | 2026-10-15 |
| Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) for Insomnia During the Withdrawal-Rehabilitation Period of Methamphetamine Use Disorder taVNS, sham-taVNS - Insomnia | Not applicable | Not yet recruiting | The First Affiliated Hospital of Zhejiang Chinese Medical University | 96 | 2026-10-01 | 2026-10-28 |
| taVNS in Veterans With Knee OA (AVAHCS) Methylprednisolone acetate, taVNS - Knee Osteoarthritis | Not applicable | Recruiting | VA Office of Research and Development | 40 | 2026-09-29 | 2026-10-05 |
| Dexmedetomidine Combined With Transcutaneous Vagus Nerve Stimulation (taVNS) Can Reduce the Incidence of PTSD in Trauma Patients After Surgery Dexmedetomidine 0.1μg/kg/h, tavns - PTSD - Post Traumatic Stress Disorder, taVNS | Not applicable | Recruiting | Affiliated Hospital of Nantong University | 300 | 2026-09-12 | 2026-09-17 |
| The Effect and Mechanism of taVNS in Modulating Human Social Attention taVNS - Healthy Adult, Role of Vagal Stimulation in Oxytocin Release | Not applicable | Recruiting | University of Electronic Science and Technology of China | 120 | 2026-08-01 | 2026-09-01 |
| Rapid Entrainment and Signal-guided Neuromodulation for Behavioral Health AIP-Informed Integrative Psychotherapy, Transcutaneous Auricular Vagus Nerve Stimulation, Regulated Breathing and Autonomic Regulation - Anxiety, PTSD | Not applicable | Active not recruiting | Tactical Mind Research Coalition, Inc. | 240 | 2026-08-01 | 2026-09-16 |
| Investigating the Neurophysiology of the Motor System and the Feasibility of Vagus Nerve Stimulation in Functional Neurological Disorder (FND) Vagial Nerve Stimulation (VNS) active stimulation, Vagial Nerve Stimulation (VNS) sham stimulation - Functional Neurological Disorder, Motor Symptoms | Not applicable | Not yet recruiting | University of Fribourg | 68 | 2026-07-01 | 2026-07-17 |
| ME/CFS Brain Fog: Cognitive Rehabilitation Trial Processing Speed Training, In-session Instrumental Activities of Daily Living Training, Transfer Package - ME/CFS, ME/CFS Following EBV-associated Infectious Mononucleosis | Not applicable | Recruiting | University of Alabama at Birmingham | 30 | 2026-06-23 | 2026-10-29 |
| Effects of Transcutaneous Vagus Nerve Stimulation in Parkinson´s Disease Transcutaneous Electrical Nerve Stimulation (TENS) of Vagus Nerve, Conventional Physical therapy, Conventional Speech Therapy - Transcutaneous Vagal Nerve Stimulation (tVNS), Parkinson Disease (PD) | Not applicable | Active not recruiting | Universidade da Coruña | 46 | 2026-05-25 | 2026-08-07 |
| Clinical Application of Vagus Nerve Stimulation Combined With Immunoregulatory T Cells in Alleviating Aromatase Inhibitor-Induced Pain transcutaneous auricular vagus nerve stimulation, sham stimulation - Aromatase Inhibitor Associated Musculoskeletal Symptoms (AIMSS), Breast Cancer | Not applicable | Not yet recruiting | Peking University People's Hospital | 216 | 2026-05-06 | 2026-05-18 |
| Effect of Recording Duration on Heart Rate Variability During taVNS Transcutaneous Auricular Vagus Nerve Stimulation, Sham Stimulation - Healthy Volunteers | Not applicable | Not yet recruiting | Sinop University | 40 | 2026-05-01 | 2026-04-16 |
| taVNS + CCT for Neurocognitive Rehab taVNS, Computerized Cognitive Training - Psychosocial Well-being, Neurocognitive Function | Not applicable | Recruiting | Medical University of South Carolina | 20 | 2026-03-12 | 2026-10-23 |
| Association of VAgus Nerve Stimulation and Treadmill Training for GAit Rehabilitation in DE Novo Parkinson's Disease Transcutaneous Auricular Vagus Nerve Stimulation (taVNS), Sham Transcutaneous Auricular Vagus Nerve Stimulation (Sham taVNS), Conventional Physical Therapy (cPT) - Idiopathic Parkinson's Disease (PD) | Not applicable | Recruiting | Fondazione Policlinico Universitario Campus Bio-Medico | 60 | 2026-02-14 | 2026-07-16 |
| Transauricular Vagus Nerve Stimulation for Chronic Whiplash Associated Disorders Transauricular Vagal Nerve Stimulation - Whiplash Associated Disorder (WAD) | Not applicable | Recruiting | University of Calgary | 40 | 2026-01-21 | 2026-05-01 |
Showing 20 of 63. Sign in to see all of them.
Parkinson Disease (5) · Anxiety Disorders (3) · Cognitive Dysfunction (3) · Depression (3) · Stress Disorders, Post-Traumatic (3) · Abdominal Pain (2) · Brain Injuries, Traumatic (2) · Chronic Pain (2) · Dysmenorrhea (2) · Fatigue (2) · Fatigue Syndrome, Chronic (2) · Fibromyalgia (2) · Hemiplegia (2) · Inflammation (2) · Insulin Resistance (2)
Medical University of South Carolina (5) · Beijing Tongren Hospital (4) · University of Alabama at Birmingham (3) · Aalborg University (2) · Air Force Military Medical University, China (2) · Istanbul Gelisim University (2) · Maastricht University Medical Center (2) · Second Affiliated Hospital, Zhejiang University, School of Medicine (2) · University of Electronic Science and Technology of China (2) · Affiliated Hospital of Jiaxing University (1) · Affiliated Hospital of Nantong University (1) · Bandırma Onyedi Eylül University (1) · Burrell College of Health Sciences (1) · Charles Raison (1) · Columbia University (1)
United States (24) · China (17) · Turkey (Türkiye) (5) · Denmark (2) · Brazil (1) · Canada (1) · Germany (1) · Italy (1) · Luxembourg (1) · Netherlands (1) · Portugal (1) · Spain (1) · Switzerland (1) · Taiwan (1)
Alexandra Evancho, DPT (1) · Alyssa Smith, MD (1) · Anna Woodbury, MD (1) · Ashley Smith (1) · Bashar Badran, PhD (1) · Beth Gottlieb, MD (1) · Betty Diamond, MD (1) · Brian A. Fallon, MD (1) · Brian Pinkston, MD, MPH (1) · Charles Raison, MD (1) · Cheryl Lowry, MD, MPH (1) · Chia-Hao Ma, MD (1) · Cristin Welle, PhD (1)
PMID 34138761, PMID 17106618, PMID 20703890, PMID 21382575, PMID 25576060, PMID 26143052, PMID 2748771, PMID 27916278, PMID 30146041, PMID 32256328, PMID 32289710, PMID 32604939, PMID 32765039, PMID 36081005, PMID 36438970, PMID 36673817, PMID 3670870, PMID 37053429, PMID 37220527, PMID 37329979, PMID 39085951, PMID 39273470, PMID 40359320, PMID 40465996, PMID 40576705, PMID 41211817, PMID 41332177, PMID 41562733, PMID 41824217, PMID 41899778, PMID 42153655, PMID 42347126, PMID 8598068
P2CHD086844 (2), K01AT012208 (1), P20GM109040 (1), R42HD104409 (1), U01DK140933 (1), U01OH012050 (1)