6 completed, 4 unknown, 2 terminated. 6 Not applicable, 2 Phase 1, 2 Phase 3, 1 Early Phase 1, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 6 | Completed 5, Terminated 1 |
| Phase 1 | 2 | Completed 1, Terminated 1 |
| Phase 3 | 2 | Unknown 2 |
| Early Phase 1 | 1 | Unknown 1 |
| Phase 2 | 1 | Completed 1 |
| Phase 4 | 1 | Unknown 1 |
Follow Tauroursodeoxycholic Acid: new trials by email Literature Review of Tauroursodeoxycholic Acid trials Research Report on Tauroursodeoxycholic Acid
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Open Label Extension of TUDCA-ALS Study Tauroursodeoxycholic Acid - Amyotrophic Lateral Sclerosis | Phase 3 | Unknown | Humanitas Mirasole SpA | 184 | 2021-10-25 | 2023-03-03 |
| The Clinical Application of Tauroursodeoxycholic Acid in Patients With Liver Fibrosis. Tauroursodeoxycholic acid, Placebo - Liver Cirrhosis | Early Phase 1 | Unknown | The First Affiliated Hospital with Nanjing Medical University | 60 | 2021-03-05 | 2021-03-09 |
| Safety and Efficacy of TUDCA as add-on Treatment in Patients Affected by ALS Tauroursodeoxycholic Acid, Placebo - Amyotrophic Lateral Sclerosis (ALS) | Phase 3 | Unknown | Humanitas Mirasole SpA | 337 | 2019-02-22 | 2023-07-10 |
| Trial of Tauroursodeoxycholic Acid (TUDCA) in Asthma Tauroursodeoxycholic Acid - Asthma | Phase 1 | Terminated | University of Vermont | 11 | 2019-01-10 | 2019-09-16 |
| A Trial of Bile Acid Supplementation in Patients With Multiple Sclerosis Tauroursodeoxycholic Acid, Placebo oral capsule - Progressive Multiple Sclerosis | Phase 1 / Phase 2 | Completed | Johns Hopkins University | 59 | 2018-06-19 | 2023-05-03 |
| Effects of TUDCA on Endothelial Function in Type 2 DM Tauroursodeoxycholic acid - Diabetes Mellitus, Type 2, Insulin Response | Not applicable | Terminated | Boston University | 2 | 2018-04-02 | 2021-03-24 |
| Effects of Dietary Supplement Tauroursodeoxycholic Acid on Vascular Function Tauroursodeoxycholic acid, Placebo - Type 2 Diabetes Mellitus | Not applicable | Completed | University of Missouri-Columbia | 8 | 2015-10-28 | 2018-02-19 |
| Tauroursodeoxycholic Acid for Protease-inhibitor Associated Insulin Resistance Tauroursodeoxycholic acid, Placebo tablet - HIV Related Insulin Resistance, Protease Inhibitor Related Insulin Resistance | Not applicable | Completed | Washington University School of Medicine | 27 | 2013-09-01 | 2020-01-27 |
| The Discovery of the Double Sphincter in Gallbladder Tauroursodeoxycholic acid - Gallstone | Phase 4 | Unknown | The First Affiliated Hospital of Guangzhou Medical University | 150 | 2012-12-01 | 2016-03-08 |
| Effect of Endoplasmic Reticulum Stress on Metabolic Function tauroursodeoxycholic acid, placebo, sodium phenylbutyrate - Insulin Resistance, Diabetes | Not applicable | Completed | Washington University School of Medicine | 101 | 2008-02-01 | 2018-05-29 |
| Randomized Study of Tauroursodeoxycholic Acid in Prophylactic Therapy of Total Parenteral Nutrition Associated Cholestasis in Infants tauroursodeoxycholic acid - Cholestasis | Not applicable | Completed | Children's Hospital Medical Center, Cincinnati | 50 | 1998-06-01 | 2015-03-25 |
| Study of Tauroursodeoxycholic Acid for Hepatobiliary Disease in Cystic Fibrosis tauroursodeoxycholic acid, ursodiol - Cystic Fibrosis | Not applicable | Completed | Children's Hospital Medical Center, Cincinnati | 39 | 1997-09-01 | 2015-03-25 |
Diabetes Mellitus, Type 2 (3) · Amyotrophic Lateral Sclerosis (2) · Insulin Resistance (2) · Rare Diseases (2) · Asthma (1) · Cholestasis (1) · Cystic Fibrosis (1) · Diabetes Mellitus (1) · Gallstones (1) · Gastrointestinal Diseases (1) · Genetic Diseases, Inborn (1) · Liver Cirrhosis (1) · Multiple Sclerosis, Chronic Progressive (1) · Obesity (1) · Respiratory Tract Diseases (1)
Children's Hospital Medical Center, Cincinnati (2) · Humanitas Mirasole SpA (2) · Washington University School of Medicine (2) · Boston University (1) · Johns Hopkins University (1) · The First Affiliated Hospital of Guangzhou Medical University (1) · The First Affiliated Hospital with Nanjing Medical University (1) · University of Missouri-Columbia (1) · University of Vermont (1)
United States (8) · Italy (3) · Belgium (2) · France (2) · Germany (2) · Ireland (2) · Netherlands (2) · United Kingdom (2) · China (1)
Alberto Albanese, MD (1) · Chengyi Sun, M.D. (1) · David Kaminsky, MD (1) · Dominic N. Reeds, M.D. (1) · James Heubi (1) · Jaume Padilla, PhD (1) · Kenneth Setchell (1) · Naomi Hamburg, MD (1) · Pavan Bhargava, MBBS, MD (1) · Samuel Klein, MD (1)
PMID 20522594, PMID 38053196, PMID 39447576
2018 (1), R01DK096982 (1)