50 completed, 25 recruiting, 7 not yet recruiting, 7 terminated. 56 Phase 2, 22 Phase 1, 20 Phase 3, 8 Not applicable, 2 Early Phase 1.
Follow this drug Literature Review of Surgical Procedure trials Research Report on Surgical Procedure
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| CCR5 Targeting Leronlimab in Combination With Hepatic Arterial Infusion Floxuridine and Systemic Therapy for the Treatment of Colorectal Cancer Liver Metastases, CHAMP Trial Biopsy Procedure, Biospecimen Collection, Computed Tomography - Metastatic Colorectal Carcinoma, Metastatic Malignant Neoplasm in the Liver | Phase 1 | Not yet recruiting | City of Hope Medical Center | 36 | 2027-05-06 | 2026-09-25 |
| Autologous Tumor Infiltrating Lymphocytes With Interleukin-2 for the Treatment of Locally Advanced, Recurrent or Metastatic Gastrointestinal Stromal Tumors Aldesleukin, Biospecimen Collection, Chest Radiography - Locally Advanced Gastrointestinal Stromal Tumor, Metastatic Gastrointestinal Stromal Tumor | Phase 2 | Not yet recruiting | Joal Beane | 59 | 2027-02-15 | 2026-10-13 |
| SMAD4 Tailored Neoadjuvant Therapy for the Treatment of Resectable and Borderline Resectable Pancreatic Ductal Adenocarcinoma, SMART-PANC Trial Biospecimen Collection, Computed Tomography, Electronic Health Record Review - Borderline Resectable Pancreatic Ductal Adenocarcinoma, Resectable Pancreatic Ductal Adenocarcinoma | Phase 2 | Not yet recruiting | Northwestern University | 125 | 2027-02-03 | 2026-08-06 |
| Intraoperative Neuromonitoring of Sacral Reflexes to Predict Post Operative Function in Patients Undergoing Sacrectomy for Pelvic Bone Malignancy or Patients Undergoing Spinal Procedures Without Sacral Root Involvement Intraoperative Nerve Monitoring, Surgical Procedure, Survey Administration - Bone Neoplasm, Metastatic Malignant Neoplasm in the Bone | Not applicable | Not yet recruiting | City of Hope Medical Center | 50 | 2027-01-10 | 2026-07-16 |
| Testing Short-Course Radiation Versus Standard-Course Radiation for Soft Tissue Sarcomas That Need Surgery and Radiation 3-Dimensional Conformal Radiation Therapy, Biospecimen Collection, Computed Tomography - Recurrent Soft Tissue Sarcoma of the Trunk and Extremities, Resectable Soft Tissue Sarcoma of the Trunk and Extremities | Phase 3 | Recruiting | SWOG Cancer Research Network | 296 | 2026-12-02 | 2026-10-13 |
| PH Weighted Chemical Exchange Saturation Transfer MRI-Based Surgical Resection to Improve Survival in Patients With Glioblastoma Chemical Exchange Saturation Transfer Magnetic Resonance Imaging, Contrast-enhanced Magnetic Resonance Imaging, Magnetic Resonance Imaging - Glioblastoma | Phase 3 | Not yet recruiting | Jonsson Comprehensive Cancer Center | 60 | 2026-12-01 | 2026-07-07 |
| Pembrolizumab and Radiation Therapy With or Without Neoadjuvant Doxorubicin and Ifosfamide for the Treatment of High-Risk Resectable Undifferentiated Pleomorphic Sarcoma or Liposarcoma of the Extremity or Trunk Wall Biospecimen Collection, Computed Tomography, Doxorubicin - Resectable Liposarcoma, Resectable Soft Tissue Sarcoma | Phase 3 | Not yet recruiting | Ohio State University Comprehensive Cancer Center | 228 | 2026-12-01 | 2026-09-16 |
| Intraoperative Methadone for the Management of Postoperative Pain in Patients With Head and Neck Cancers Electronic Health Record Review, Fentanyl, Laryngoscopy - Head and Neck Carcinoma, Hypopharyngeal Carcinoma | Phase 4 | Recruiting | OHSU Knight Cancer Institute | 58 | 2026-09-22 | 2026-10-05 |
| Proton Spatially Fractionated Radiotherapy or Photon Stereotactic Body Radiotherapy in Combination With Pembrolizumab Before Surgery for the Treatment of Locally Advanced and Radiation-Naive Locoregionally Recurrent Oral Cavity Cancer, OSPRI Trial Biopsy Procedure, Biospecimen Collection, Computed Tomography - Locally Advanced Oral Cavity Squamous Cell Carcinoma, Locally Recurrent Oral Cavity Squamous Cell Carcinoma | Phase 2 | Not yet recruiting | Mayo Clinic | 30 | 2026-09-07 | 2026-08-25 |
| Testing the Addition of Cemiplimab (REGN2810) to Chemotherapy Treatment Given Prior to Surgery in Patients With Sinonasal Squamous Cell Carcinoma Biopsy Procedure, Biospecimen Collection, Carboplatin - Sinonasal Squamous Cell Carcinoma, Stage III Sinonasal Cancer AJCC v8 | Phase 2 | Recruiting | National Cancer Institute (NCI) | 108 | 2026-09-01 | 2026-10-05 |
| GI-102 Alone or With Pembrolizumab Before Surgery for Treatment of Recurrent or Progressive IDH Wildtype Glioblastoma and IDH Mutated Grade 4 Astrocytoma Biospecimen Collection, Bispecific CD80-lgG4Fc-IL-2v Fusion Protein GI-102, Computed Tomography - Glioblastoma, IDH-Wildtype, Progressive Astrocytoma, IDH-Mutant, Grade 4 | Phase 2 | Recruiting | Mayo Clinic | 36 | 2026-08-03 | 2026-10-01 |
| Propranolol Plus Standard Radiation Therapy Before Surgery for the Treatment of Patients With Soft Tissue Sarcoma Biopsy, Biospecimen Collection, Computed Tomography - Soft Tissue Sarcoma | Phase 1 | Withdrawn | Roswell Park Cancer Institute | 2026-05-15 | 2025-08-26 | |
| NALIRIFOX Before Surgery for the Treatment of Borderline Resectable Pancreatic Ductal Adenocarcinoma, Nectar Trial Biospecimen Collection, Computed Tomography, Fluorouracil - Borderline Resectable Pancreatic Ductal Adenocarcinoma | Phase 2 | Recruiting | Roswell Park Cancer Institute | 20 | 2026-03-02 | 2026-09-21 |
| Decitabine in Combination With Standard of Care Therapy for the Treatment of Surgically Resectable HPV-Negative Head and Neck Cancer Biospecimen Collection, Chemotherapy, Decitabine - Human Papillomavirus-Negative Neck Squamous Cell Carcinoma, Resectable Head and Neck Squamous Cell Carcinoma | Phase 1 | Recruiting | Mayo Clinic | 32 | 2026-01-23 | 2026-07-15 |
| Neoadjuvant Therapy for the Treatment of Gastroesophageal Junction and Gastric Cancers Capecitabine, Docetaxel, Fluorouracil - Clinical Stage I Gastric Cancer AJCC v8, Clinical Stage II Gastric Cancer AJCC v8 | Phase 1 | Withdrawn | Ohio State University Comprehensive Cancer Center | 2025-12-31 | 2025-02-07 | |
| Hyperthermic Intraperitoneal Chemotherapy With Cisplatin and Paclitaxel for Gastric Cancer at High Risk of Peritoneal Recurrence Biopsy Procedure, Biospecimen Collection, Cisplatin - Clinical Stage I Gastric Cancer AJCC v8, Clinical Stage I Gastroesophageal Junction Adenocarcinoma AJCC v8 | Phase 2 | Enrolling by invitation | Mayo Clinic | 16 | 2025-12-03 | 2026-07-01 |
| Ivonescimab Before Surgery for the Treatment of Resectable Stage II-IV Head and Neck Cancer Biopsy Procedure, Biospecimen Collection, Computed Tomography - Advanced Head and Neck Squamous Cell Carcinoma, Resectable Head and Neck Squamous Cell Carcinoma | Phase 2 | Recruiting | University of Michigan Rogel Cancer Center | 28 | 2025-11-18 | 2026-06-26 |
| Testing a New Combination of Anti-cancer Drugs in Patients Newly Diagnosed With Ewing Sarcoma Who Have Cancer That Has Spread to Other Parts of the Body Biopsy Procedure, Biospecimen Collection, Bone Marrow Aspiration - CIC-Rearranged Sarcoma, Metastatic Ewing Sarcoma | Phase 2 / Phase 3 | Terminated | Children's Oncology Group | 2 | 2025-11-10 | 2026-10-05 |
| Intratumoral Injection of Standard Universal Donor Expanded Natural Killer Cells and TGF-beta Imprinted Natural Killer Cells for the Treatment of Skin Squamous Cell Carcinoma and Basal Cell Carcinoma Biopsy Procedure, Natural Killer Cell Therapy, Surgical Procedure - Skin Basal Cell Carcinoma, Skin Nodular Basal Cell Carcinoma | Early Phase 1 | Completed | Ohio State University Comprehensive Cancer Center | 4 | 2025-10-16 | 2026-09-28 |
| Neoadjuvant Darolutamide Alone or in Combination With Standard Therapy for Stage II-IIIA, AR+, TNBC Biospecimen Collection, Breast Biopsy Procedure, Carboplatin - Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage IIIA Breast Cancer AJCC v8 | Phase 2 | Recruiting | Vandana Abramson | 51 | 2025-09-09 | 2025-10-30 |
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Glioblastoma (16) · Brain Neoplasms (11) · Central Nervous System Neoplasms (11) · Gliosarcoma (11) · Astrocytoma (10) · Glioma (7) · Oligodendroglioma (6) · Esophageal Neoplasms (5) · Oropharyngeal Neoplasms (5) · Ovarian Neoplasms (5) · Sarcoma (5) · Adenocarcinoma Of Esophagus (4) · Breast Neoplasms (4) · Carcinoma, Ovarian Epithelial (4) · Colorectal Neoplasms (4)
National Cancer Institute (NCI) (9) · Mayo Clinic (7) · Ohio State University Comprehensive Cancer Center (5) · Alliance for Clinical Trials in Oncology (4) · Jonsson Comprehensive Cancer Center (4) · Memorial Sloan Kettering Cancer Center (4) · SWOG Cancer Research Network (4) · Children's Oncology Group (3) · Duke University (3) · European Organisation for Research and Treatment of Cancer - EORTC (3) · M.D. Anderson Cancer Center (3) · Northwestern University (3) · Roswell Park Cancer Institute (3) · Barbara Ann Karmanos Cancer Institute (2) · Barrett Cancer Center (2)
United States (90) · Canada (8) · United Kingdom (6) · France (5) · Puerto Rico (5) · Australia (4) · Austria (3) · Italy (3) · Netherlands (3) · South Korea (3) · Germany (2) · New Zealand (2) · Spain (2) · Switzerland (2) · Belgium (1)
Darell D. Bigner, MD, PhD (2) · Henry S. Friedman, MD (2) · Adam L. Holtzman, MD (1) · Ahmad Tarhini (1) · Alana M Munger (1) · Amy Heimberger (1) · Andrew E. Sloan, MD (1) · Anthony S Dakwar (1) · Anurag K Singh (1) · Arjun Mittra, MD (1) · Arlene A. Forastiere, MD (1) · Bhuvana A Setty (1) · Brenda W. Cooper, MD (1) · Brett L Ecker, MD (1) · Christos Fountzilas (1)
PMID 10210538, PMID 12167786, PMID 12610186, PMID 12697884, PMID 12721251, PMID 15001263, PMID 15158627, PMID 15328187, PMID 15542799, PMID 15547181, PMID 16012523, PMID 16062084, PMID 16258095, PMID 16314640, PMID 16622435, PMID 16817692, PMID 16849759, PMID 17466514, PMID 17493669, PMID 17574960, PMID 17878477, PMID 17925548, PMID 18309943, PMID 19328574, PMID 19846959, PMID 20878462, PMID 23496877, PMID 30267838, PMID 32767659, PMID 32827353, PMID 32920242, PMID 33844174, PMID 38573872, PMID 40473291, PMID 40873341, PMID 41047708, PMID 41137728, PMID 41213254, PMID 41604000, PMID 41747891
U10CA180886 (4), P30CA060553 (3), U10CA180820 (3), U10CA180888 (3), P30CA022453 (2), P30CA033572 (2), U10CA031946 (2), U10CA180821 (2), U10CA180868 (2), K12HD001262 (1), N01CN00034 (1), P30CA006927 (1), P30CA012197 (1), P30CA014089 (1), P30CA016087 (1)