13 recruiting, 3 active not recruiting, 3 completed, 2 not yet recruiting. 28 Phase 2, 2 Phase 1, 2 Phase 3.
Follow Surgical: new trials by email Literature Review of Surgical trials Research Report on Surgical
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Autologous Tumor Infiltrating Lymphocytes With Interleukin-2 for the Treatment of Locally Advanced, Recurrent or Metastatic Gastrointestinal Stromal Tumors Aldesleukin, Biospecimen Collection, Chest Radiography - Locally Advanced Gastrointestinal Stromal Tumor, Metastatic Gastrointestinal Stromal Tumor | Phase 2 | Not yet recruiting | Joal Beane | 59 | 2027-02-15 | 2026-10-13 |
| SMAD4 Tailored Neoadjuvant Therapy for the Treatment of Resectable and Borderline Resectable Pancreatic Ductal Adenocarcinoma, SMART-PANC Trial Biospecimen Collection, Computed Tomography, Electronic Health Record Review - Borderline Resectable Pancreatic Ductal Adenocarcinoma, Resectable Pancreatic Ductal Adenocarcinoma | Phase 2 | Recruiting | Northwestern University | 125 | 2026-10-26 | 2026-10-29 |
| Proton Spatially Fractionated Radiotherapy or Photon Stereotactic Body Radiotherapy in Combination With Pembrolizumab Before Surgery for the Treatment of Locally Advanced and Radiation-Naive Locoregionally Recurrent Oral Cavity Cancer, OSPRI Trial Biopsy Procedure, Biospecimen Collection, Computed Tomography - Locally Advanced Oral Cavity Squamous Cell Carcinoma, Locally Recurrent Oral Cavity Squamous Cell Carcinoma | Phase 2 | Not yet recruiting | Mayo Clinic | 30 | 2026-09-07 | 2026-08-25 |
| Testing the Addition of Cemiplimab (REGN2810) to Chemotherapy Treatment Given Prior to Surgery in Patients With Sinonasal Squamous Cell Carcinoma Biopsy Procedure, Biospecimen Collection, Carboplatin - Sinonasal Squamous Cell Carcinoma, Stage III Sinonasal Cancer AJCC v8 | Phase 2 | Recruiting | National Cancer Institute (NCI) | 108 | 2026-09-01 | 2026-10-05 |
| GI-102 Alone or With Pembrolizumab Before Surgery for Treatment of Recurrent or Progressive IDH Wildtype Glioblastoma and IDH Mutated Grade 4 Astrocytoma Biospecimen Collection, Bispecific CD80-lgG4Fc-IL-2v Fusion Protein GI-102, Computed Tomography - Glioblastoma, IDH-Wildtype, Progressive Astrocytoma, IDH-Mutant, Grade 4 | Phase 2 | Recruiting | Mayo Clinic | 36 | 2026-08-03 | 2026-10-30 |
| NALIRIFOX Before Surgery for the Treatment of Borderline Resectable Pancreatic Ductal Adenocarcinoma, Nectar Trial Biospecimen Collection, Computed Tomography, Fluorouracil - Borderline Resectable Pancreatic Ductal Adenocarcinoma | Phase 2 | Recruiting | Roswell Park Cancer Institute | 20 | 2026-03-02 | 2026-09-21 |
| Hyperthermic Intraperitoneal Chemotherapy With Cisplatin and Paclitaxel for Gastric Cancer at High Risk of Peritoneal Recurrence Biopsy Procedure, Biospecimen Collection, Cisplatin - Clinical Stage I Gastric Cancer AJCC v8, Clinical Stage I Gastroesophageal Junction Adenocarcinoma AJCC v8 | Phase 2 | Enrolling by invitation | Mayo Clinic | 16 | 2025-12-03 | 2026-07-01 |
| Ivonescimab Before Surgery for the Treatment of Resectable Stage II-IV Head and Neck Cancer Biopsy Procedure, Biospecimen Collection, Computed Tomography - Advanced Head and Neck Squamous Cell Carcinoma, Resectable Head and Neck Squamous Cell Carcinoma | Phase 2 | Recruiting | University of Michigan Rogel Cancer Center | 28 | 2025-11-18 | 2026-06-26 |
| Testing a New Combination of Anti-cancer Drugs in Patients Newly Diagnosed With Ewing Sarcoma Who Have Cancer That Has Spread to Other Parts of the Body Biopsy Procedure, Biospecimen Collection, Bone Marrow Aspiration - CIC-Rearranged Sarcoma, Metastatic Ewing Sarcoma | Phase 2 / Phase 3 | Terminated | Children's Oncology Group | 2 | 2025-11-10 | 2026-10-05 |
| Neoadjuvant Darolutamide Alone or in Combination With Standard Therapy for Stage II-IIIA, AR+, TNBC Biospecimen Collection, Breast Biopsy Procedure, Carboplatin - Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage IIIA Breast Cancer AJCC v8 | Phase 2 | Recruiting | Vandana Abramson | 51 | 2025-09-09 | 2025-10-30 |
| Cemiplimab and Fianlimab Before Surgery for the Treatment of Stage IB-IIIB Non-Small Cell Lung Cancer Biospecimen Collection, Cemiplimab, Fianlimab - Lung Non-Small Cell Carcinoma, Stage IB Lung Cancer AJCC v8 | Phase 2 | Recruiting | Mayo Clinic | 60 | 2025-05-02 | 2026-10-29 |
| Testing the Combination of Anti-cancer Drugs Tiragolumab and Atezolizumab to Improve Outcomes for Patients With Recurrent Glioblastoma Atezolizumab, Biospecimen Collection, Magnetic Resonance Imaging - Recurrent Glioblastoma, IDH-Wildtype | Phase 2 | Withdrawn | National Cancer Institute (NCI) | 2025-04-30 | 2024-12-30 | |
| Anti-Lag-3 (Relatlimab) and Anti-PD-1 Blockade (Nivolumab) Versus Standard of Care (Lomustine) for the Treatment of Patients With Recurrent Glioblastoma Biopsy Procedure, Biospecimen Collection, Lomustine - Progressive Glioblastoma, Recurrent Glioblastoma | Phase 2 | Suspended | National Cancer Institute (NCI) | 184 | 2024-11-08 | 2026-10-30 |
| A Study of Lower Radiotherapy Dose to Treat Children With CNS Germinoma 3-Dimensional Conformal Proton Radiation Therapy, 3-Dimensional Conformal Radiation Therapy, Biospecimen Collection - Basal Ganglia Germinoma, Diabetes Insipidus | Phase 2 | Recruiting | Children's Oncology Group | 240 | 2024-10-22 | 2026-08-25 |
| Fluorescence Image Guided Surgery Followed by Intraoperative Photodynamic Therapy for Improving Local Tumor Control in Patients With Locally Advanced or Recurrent Colorectal Cancer Aminolevulinic Acid, Biospecimen Collection, Computed Tomography - Locally Advanced Colorectal Carcinoma, Recurrent Colorectal Carcinoma | Phase 1 / Phase 2 | Recruiting | Roswell Park Cancer Institute | 21 | 2024-07-30 | 2026-10-15 |
| WP1066 and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Biospecimen Collection, Magnetic Resonance Imaging, Radiation Therapy - Glioblastoma, IDH-Wildtype, MGMT-Unmethylated Glioblastoma | Phase 2 | Recruiting | Northwestern University | 39 | 2024-05-22 | 2026-07-22 |
| Carboplatin Chemotherapy Before Surgery for People With High-Risk Prostate Cancer and an Inherited BRCA1 or BRCA2 Gene Mutation Biospecimen Collection, Carboplatin, Chest Radiography - Prostate Adenocarcinoma, Stage IIIB Prostate Cancer AJCC v8 | Phase 2 | Recruiting | SWOG Cancer Research Network | 44 | 2024-03-01 | 2026-01-29 |
| Testing Immunotherapy (Atezolizumab) With or Without Chemotherapy in Locoregional MSI-H/dMMR Gastric and Gastroesophageal Junction (GEJ) Cancer Atezolizumab, Biospecimen Collection, Capecitabine - Clinical Stage I Gastric Cancer AJCC v8, Clinical Stage I Gastroesophageal Junction Adenocarcinoma AJCC v8 | Phase 2 | Active not recruiting | National Cancer Institute (NCI) | 2 | 2023-12-06 | 2026-07-01 |
| Inhalational or Intravenous Anesthesia During Surgery for Patients With Colon Cancer, VIVA Study Biospecimen Collection, Electronic Health Record Review, Fentanyl Citrate - Colon Adenocarcinoma | Phase 2 | Unknown | University of Kansas Medical Center | 80 | 2023-05-22 | 2023-08-30 |
| Testing the Role of FDG-PET/CT to Predict Response to Therapy Prior to Surgery for HER2-positive Breast Cancer, The DIRECT Trial Chemotherapy, Computed Tomography, Fludeoxyglucose F-18 - Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage III Breast Cancer AJCC v8 | Phase 2 | Active not recruiting | ECOG-ACRIN Cancer Research Group | 235 | 2023-05-10 | 2026-10-19 |
Showing 20 of 28. Sign in to see all of them.
Glioblastoma (5) · Astrocytoma (1) · Carcinoma, Hepatocellular (1) · Carcinoma, Intraductal, Noninfiltrating (1) · Carcinoma, Non-Small-Cell Lung (1) · Colonic Neoplasms (1) · Colorectal Neoplasms (1) · Diabetes Insipidus (1) · Fallopian Tube Neoplasms (1) · Gastrointestinal Stromal Tumors (1) · Germinoma (1) · Glioma (1) · Gliosarcoma (1) · Lung Neoplasms (1) · Melanoma (1)
National Cancer Institute (NCI) (7) · Mayo Clinic (4) · Children's Oncology Group (3) · Northwestern University (3) · M.D. Anderson Cancer Center (2) · Roswell Park Cancer Institute (2) · ECOG-ACRIN Cancer Research Group (1) · Joal Beane (1) · SWOG Cancer Research Network (1) · University of Kansas Medical Center (1) · University of Michigan Rogel Cancer Center (1) · Vandana Abramson (1) · Wake Forest University Health Sciences (1)
United States (27) · Australia (3) · Canada (3) · New Zealand (2) · Puerto Rico (2) · Saudi Arabia (1)
Ahmad Tarhini (1) · Amy Heimberger (1) · Anthony S Dakwar (1) · Bhuvana A Setty (1) · Brett L Ecker, MD (1) · Christos Fountzilas (1) · Daniel K. Ebner, MD, MPH (1) · Heather H Cheng (1) · Heather Jacene (1) · James I Geller (1) · Jeffrey Raizer, MD (1) · Jian L Campian, MD, PhD (1) · Joal Beane, MD (1) · Kaushal Parikh, MBBS (1) · Lakshmi Rajdev (1)
PMID 38573872, PMID 41047708, PMID 41604000
U10CA180886 (4), P30CA060553 (3), U10CA180820 (3), N01CN00034 (1), P30CA012197 (1), P30CA016672 (1), P30CA068485 (1), P30CA168524 (1), U10CA180821 (1), U10CA180888 (1), UL1TR001412 (1), UM1CA186690 (1), UM1CA186712 (1)