265 completed, 141 unknown, 132 recruiting, 79 terminated. 279 Phase 2, 172 Not applicable, 90 Phase 3, 52 Phase 1, 17 Phase 4.
Follow this drug Literature Review of surgery trials Research Report on surgery
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| CCR5 Targeting Leronlimab in Combination With Hepatic Arterial Infusion Floxuridine and Systemic Therapy for the Treatment of Colorectal Cancer Liver Metastases, CHAMP Trial Biopsy Procedure, Biospecimen Collection, Computed Tomography - Metastatic Colorectal Carcinoma, Metastatic Malignant Neoplasm in the Liver | Phase 1 | Not yet recruiting | City of Hope Medical Center | 36 | 2027-05-06 | 2026-09-25 |
| Autologous Tumor Infiltrating Lymphocytes With Interleukin-2 for the Treatment of Locally Advanced, Recurrent or Metastatic Gastrointestinal Stromal Tumors Aldesleukin, Biospecimen Collection, Chest Radiography - Locally Advanced Gastrointestinal Stromal Tumor, Metastatic Gastrointestinal Stromal Tumor | Phase 2 | Not yet recruiting | Joal Beane | 59 | 2027-02-15 | 2026-10-13 |
| SMAD4 Tailored Neoadjuvant Therapy for the Treatment of Resectable and Borderline Resectable Pancreatic Ductal Adenocarcinoma, SMART-PANC Trial Biospecimen Collection, Computed Tomography, Electronic Health Record Review - Borderline Resectable Pancreatic Ductal Adenocarcinoma, Resectable Pancreatic Ductal Adenocarcinoma | Phase 2 | Not yet recruiting | Northwestern University | 125 | 2027-02-03 | 2026-08-06 |
| Intraoperative Neuromonitoring of Sacral Reflexes to Predict Post Operative Function in Patients Undergoing Sacrectomy for Pelvic Bone Malignancy or Patients Undergoing Spinal Procedures Without Sacral Root Involvement Intraoperative Nerve Monitoring, Surgical Procedure, Survey Administration - Bone Neoplasm, Metastatic Malignant Neoplasm in the Bone | Not applicable | Not yet recruiting | City of Hope Medical Center | 50 | 2027-01-10 | 2026-07-16 |
| Testing Short-Course Radiation Versus Standard-Course Radiation for Soft Tissue Sarcomas That Need Surgery and Radiation 3-Dimensional Conformal Radiation Therapy, Biospecimen Collection, Computed Tomography - Recurrent Soft Tissue Sarcoma of the Trunk and Extremities, Resectable Soft Tissue Sarcoma of the Trunk and Extremities | Phase 3 | Recruiting | SWOG Cancer Research Network | 296 | 2026-12-02 | 2026-10-13 |
| PH Weighted Chemical Exchange Saturation Transfer MRI-Based Surgical Resection to Improve Survival in Patients With Glioblastoma Chemical Exchange Saturation Transfer Magnetic Resonance Imaging, Contrast-enhanced Magnetic Resonance Imaging, Magnetic Resonance Imaging - Glioblastoma | Phase 3 | Not yet recruiting | Jonsson Comprehensive Cancer Center | 60 | 2026-12-01 | 2026-07-07 |
| Pembrolizumab and Radiation Therapy With or Without Neoadjuvant Doxorubicin and Ifosfamide for the Treatment of High-Risk Resectable Undifferentiated Pleomorphic Sarcoma or Liposarcoma of the Extremity or Trunk Wall Biospecimen Collection, Computed Tomography, Doxorubicin - Resectable Liposarcoma, Resectable Soft Tissue Sarcoma | Phase 3 | Not yet recruiting | Ohio State University Comprehensive Cancer Center | 228 | 2026-12-01 | 2026-09-16 |
| Neoadjuvant Pembrolizumab in Patients With High Risk, Stage IIB/IIC Cutaneous Melanoma: a Single Arm Proof of Concept Phase IIA Study. Pembrolizumab neoadjuvant treatment, surgery, Adjuvant treatment - Stage IIB Melanoma, Stage IIC Melanoma | Phase 2 | Not yet recruiting | Centre Hospitalier Universitaire de Besancon | 19 | 2026-11-01 | 2026-10-20 |
| Comparison of an Initial Active Follow-up and Therapeutic Care on Functional Outcome and Quality of Life in Patients With Head and Neck Paragangliomas Active follow-up, Surgery, Radiation - Paragangliomas | Not applicable | Not yet recruiting | Hospices Civils de Lyon | 122 | 2026-10-10 | 2026-08-25 |
| Immunotherapy and Nodal-Sparing Irradiation for T-Cell Induction and Unmasking of Tumor Antigenicity in the Microenvironment for Head and Neck Cancer Pembrolizumab, Radiotherapy, ENI - Head and Neck Cancer Squamous Cell Carcinoma | Phase 2 | Recruiting | Medical College of Wisconsin | 20 | 2026-10-08 | 2026-10-19 |
| SAMe in Prevention of Oxaliplatin-associated Liver Injury Standard of care oxaliplatin-based chemotherapy, S-adenosylmethionine (SAMe) supplement, Surgery - Colorectal Cancer, Liver Metastases | Phase 2 | Not yet recruiting | Cedars-Sinai Medical Center | 30 | 2026-10-01 | 2026-09-30 |
| Intraoperative Methadone for the Management of Postoperative Pain in Patients With Head and Neck Cancers Electronic Health Record Review, Fentanyl, Laryngoscopy - Head and Neck Carcinoma, Hypopharyngeal Carcinoma | Phase 4 | Recruiting | OHSU Knight Cancer Institute | 58 | 2026-09-22 | 2026-10-05 |
| Proton Spatially Fractionated Radiotherapy or Photon Stereotactic Body Radiotherapy in Combination With Pembrolizumab Before Surgery for the Treatment of Locally Advanced and Radiation-Naive Locoregionally Recurrent Oral Cavity Cancer, OSPRI Trial Biopsy Procedure, Biospecimen Collection, Computed Tomography - Locally Advanced Oral Cavity Squamous Cell Carcinoma, Locally Recurrent Oral Cavity Squamous Cell Carcinoma | Phase 2 | Not yet recruiting | Mayo Clinic | 30 | 2026-09-07 | 2026-08-25 |
| NCT + PD1 + Ketogenic Diet and/or Vitamin C for LARC Short-Course Radiotherapy, PD-1 monoclonal antibody, mFOLFOX6 regimen - Rectal Adenocarcinoma, High-Risk Cancer | Phase 2 | Not yet recruiting | Sixth Affiliated Hospital, Sun Yat-sen University | 100 | 2026-09-01 | 2026-08-14 |
| Augmented Reality Dentistry Surgery, Patients requiring orthodontic treatment. - Edentulism, Malocclusion; Displaced Teeth | Not applicable | Not yet recruiting | University of Bari Aldo Moro | 10 | 2026-09-01 | 2026-09-25 |
| Iparomlimab and Tuvonralimab Combined With Chemotherapy and Bevacizumab as Neoadjuvant Therapy for Locally Advanced Rectal Cancer Iparomlimab and Tuvonralimab（QL-1706）combined with Chemotherapy and Bevacizumab - Locally Advanced Rectal Cancer (LARC), 5-12cm to Anal Verge | Not applicable | Not yet recruiting | Zhejiang University | 56 | 2026-09-01 | 2026-09-15 |
| Testing the Addition of Cemiplimab (REGN2810) to Chemotherapy Treatment Given Prior to Surgery in Patients With Sinonasal Squamous Cell Carcinoma Biopsy Procedure, Biospecimen Collection, Carboplatin - Sinonasal Squamous Cell Carcinoma, Stage III Sinonasal Cancer AJCC v8 | Phase 2 | Recruiting | National Cancer Institute (NCI) | 108 | 2026-09-01 | 2026-10-05 |
| Observational Approach Versus Surgical Intervention for Stones Surgery, Observation - Nephrolithiasis, Kidney Stone | Not applicable | Recruiting | Children's Hospital of Philadelphia | 1658 | 2026-08-17 | 2026-10-15 |
| GI-102 Alone or With Pembrolizumab Before Surgery for Treatment of Recurrent or Progressive IDH Wildtype Glioblastoma and IDH Mutated Grade 4 Astrocytoma Biospecimen Collection, Bispecific CD80-lgG4Fc-IL-2v Fusion Protein GI-102, Computed Tomography - Glioblastoma, IDH-Wildtype, Progressive Astrocytoma, IDH-Mutant, Grade 4 | Phase 2 | Recruiting | Mayo Clinic | 36 | 2026-08-03 | 2026-10-01 |
| Perioperative Finotonlimab Plus Chemotherapy in Untreated Stage II HNSCC Neoadjuvant Finotonlimab Plus Chemotherapy, Surgery, Postoperative Finotonlimab Maintenance - Head and Neck Squamous Cell Carcinoma HNSCC | Phase 2 | Not yet recruiting | Yanjie Zhang, MD | 142 | 2026-08-01 | 2026-08-07 |
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Carcinoma, Non-Small-Cell Lung (48) · Breast Neoplasms (45) · Rectal Neoplasms (40) · Stomach Neoplasms (32) · Esophageal Neoplasms (28) · Glioblastoma (28) · Lung Neoplasms (27) · Colorectal Neoplasms (25) · Squamous Cell Carcinoma of Head and Neck (24) · Pancreatic Neoplasms (23) · Sarcoma (18) · Glioma (15) · Neoplasms (15) · Brain Neoplasms (13) · Colonic Neoplasms (13)
National Cancer Institute (NCI) (16) · Sun Yat-sen University (14) · Alliance for Clinical Trials in Oncology (13) · M.D. Anderson Cancer Center (13) · Fudan University (12) · SWOG Cancer Research Network (11) · H. Lee Moffitt Cancer Center and Research Institute (10) · Shanghai Pulmonary Hospital, Shanghai, China (8) · Hoffmann-La Roche (7) · Mayo Clinic (7) · Washington University School of Medicine (7) · Masonic Cancer Center, University of Minnesota (6) · St. Jude Children's Research Hospital (6) · Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University (6) · Tianjin Medical University Cancer Institute and Hospital (6)
United States (250) · China (160) · Canada (44) · France (43) · Spain (35) · Germany (34) · Italy (29) · Taiwan (25) · Netherlands (24) · South Korea (22) · Australia (19) · Poland (19) · Sweden (19) · Austria (18) · Belgium (18)
Peng Zhang, PhD (3) · Bernard Nordlinger, Pr. (2) · Douglas Adkins, M.D. (2) · Farshad Frozanpor (2) · Hong Yang, Ph.D., M.D. (2) · Jaffer Ajani, MD (2) · Jennifer Y. Wo, MD (2) · Jiayi Huang, M.D. (2) · Lin-Fen Hsieh, M.D (2) · Luca Gianni, MD (2) · Roger Stupp, MD (2) · Theresa Ryan, MD (2) · Thomas E. Merchant, DO, PhD (2)
PMID 36648215, PMID 26808342, PMID 27864853, PMID 32827353, PMID 38913933, PMID 10071296, PMID 10581077, PMID 11241082, PMID 11556297, PMID 12471405, PMID 13129557, PMID 15222781, PMID 15555621, PMID 15701582, PMID 15825201, PMID 15928658, PMID 16219273, PMID 16235286, PMID 16757203, PMID 17042060, PMID 17235046, PMID 17307530, PMID 17311692, PMID 1742526, PMID 17627893, PMID 17917772, PMID 17978289, PMID 18088558, PMID 18098310, PMID 18215105, PMID 18254095, PMID 18301813, PMID 18486742, PMID 18626702, PMID 18640325, PMID 18723148, PMID 18780796, PMID 18784101, PMID 19128748, PMID 19138791, PMID 19224775, PMID 19258111, PMID 19371909, PMID 19411668, PMID 19465425, PMID 19486621, PMID 19573300, PMID 19767043, PMID 19770418, PMID 19830461
U10CA032102 (8), 2023 (5), 2017 (4), P30CA060553 (4), U10CA031946 (4), U10CA180886 (4), 2014 (3), 2018 (3), P30CA138292 (3), U10CA180820 (3), U10CA180868 (3), U10CA180888 (3), 2009 (2), 2016 (2), P30CA033572 (2)