17 completed, 2 not yet recruiting, 2 recruiting. 18 Not applicable, 3 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 18 | Completed 14, Not yet recruiting 2, Recruiting 2 |
| Phase 3 | 3 | Completed 3 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Spirulina Supplementation in Postmenopausal Women Spirulina, Placebo - Postmenopause, Overweight | Not applicable | Not yet recruiting | Halic University | 66 | 2026-07-01 | 2026-07-22 |
| The Preventive and Therapeutic Effects of Spirulina Preparations on Ulcers of Oral Mucosa Spirulina Tablets, Placebo Tablets - Recurrent Aphthous Stomatitis, Mouth Ulcer | Not applicable | Recruiting | The Fourth Affiliated Hospital of Zhejiang University School of Medicine | 40 | 2026-06-01 | 2026-07-23 |
| Inulin-Spirulina Co-intervention for Insomnia Disorder Inulin, Spirulina, Maltodextrin - Insomnia Disorder, Sleep Initiation and Maintenance Disorders | Not applicable | Not yet recruiting | First Affiliated Hospital of Zhejiang University | 180 | 2026-05-01 | 2026-05-19 |
| Mechanistic Study on the Protective and Regenerative Effects of Spirulina in Hepatectomy-Related Liver Injury Spirulina, Maltodextrin - Cholangiocarcinoma | Not applicable | Recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 30 | 2025-10-01 | 2025-12-04 |
| Identification of Surrogate Blood and/or Urine Biomarker for Immulina TM (Trademark) in Normal Humans Immulina - Adherence, Patient | Phase 3 | Completed | University of Mississippi Medical Center | 20 | 2023-08-09 | 2026-07-30 |
| Effects of Immulina TM Supplements With PASC Patients Immulina TM, Placebo - Post Acute COVID-19 Syndrome | Phase 3 | Completed | University of Mississippi Medical Center | 101 | 2023-07-20 | 2026-07-31 |
| Spirulina Oral Supplement for Enhancing Host Resilience to Virus Infection Immulina TM, Placebo - Healthy Volunteers | Phase 3 | Completed | University of Mississippi Medical Center | 492 | 2022-07-01 | 2026-07-30 |
| Spirulina (FEM-102) Supplement to Chronic Hepatitis B Patients Spirulina - Chronic Hepatitis b | Not applicable | Completed | Taipei Medical University WanFang Hospital | 75 | 2019-10-29 | 2021-01-22 |
| Effects of Immulina on Immune Measures Immulina Dietary Supplementation - Effects of Immulina on Natural Killer Cells | Not applicable | Completed | University of Mississippi Medical Center | 40 | 2019-09-03 | 2022-05-19 |
| Algae and Cholesterol Absorption Wakame, Spirulina, Control - Intestinal Cholesterol Absorption | Not applicable | Completed | Maastricht University Medical Center | 36 | 2017-10-24 | 2018-10-19 |
| Effects of Spirulina Supplementation on Overweight or Obese Adults Spirulina, diet therapy - Obesity | Not applicable | Completed | Shahid Beheshti University of Medical Sciences | 52 | 2016-12-01 | 2019-04-11 |
| Effect of Spirulina on Liver Fibrosis by Transient Elastography in Beta Thalassemic Children With Hepatitis C Spirulina - Beta Thalassemia Major | Not applicable | Completed | Tanta University | 60 | 2015-12-01 | 2018-09-11 |
| Effect of Spirulina on Serum Hyaluronic Acid in Beta Thalassemic Children With Hepatitis C Spirulina - Beta Thalassemia Major | Not applicable | Completed | Tanta University | 60 | 2015-12-01 | 2019-04-10 |
| the Potential Immunomodulatory Effects of Spirulina on Thalassemic Children Spirulina - Beta Thalassemia Major | Not applicable | Completed | Tanta University | 60 | 2015-10-01 | 2017-10-25 |
| Effect of Spirulina Compared to Amlodipine on Cardiac Iron Overload in Children With Beta Thalassemia Spirulina, Amlodipine - Beta Thalassemia Major | Not applicable | Completed | Tanta University | 40 | 2015-04-01 | 2018-07-12 |
| Effect of Spirulina on Liver Iron Concentration in Beta Thalassemic Children With Hepatitis C spirulina - Beta Thalassemia Major | Not applicable | Completed | Tanta University | 30 | 2015-03-01 | 2018-09-11 |
| Spirulina Supplementation and Infant Growth, Morbidity and Motor Development Spirulina, Control - Stunting, Underweight | Not applicable | Completed | Programme Against Malnutrition | 501 | 2015-03-01 | 2019-02-11 |
| Effects of Spirulina on Cardiac Functions in Children With Beta Thalassemia Major spirulina - Beta Thalassemia | Not applicable | Completed | Tanta University | 60 | 2014-11-01 | 2018-09-11 |
| Pilot Study to Evaluate Immunopotentiating Effects of Immulina in Elderly Individuals Immulina - Elderly Immune Senescence | Not applicable | Completed | University of Mississippi Medical Center | 21 | 2013-04-01 | 2016-05-26 |
| Spirulina Supplementation and Cardiovascular Risk in Obese Caucasians With Treated Hypertension Spirulina, Placebo - Obesity | Not applicable | Completed | Poznan University of Medical Sciences | 50 | 2013-01-01 | 2020-05-05 |
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beta-Thalassemia (6) · Obesity (2) · Sleep Initiation and Maintenance Disorders (2) · Body Weight (1) · Cholangiocarcinoma (1) · Cough (1) · Depression (1) · Fever (1) · Growth Disorders (1) · Hepatitis B, Chronic (1) · Inflammation (1) · Influenza, Human (1) · Keratosis (1) · Malaria (1) · Oral Ulcer (1)
Tanta University (6) · University of Mississippi Medical Center (5) · Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh (1) · First Affiliated Hospital of Zhejiang University (1) · Halic University (1) · Maastricht University Medical Center (1) · Poznan University of Medical Sciences (1) · Programme Against Malnutrition (1) · Second Affiliated Hospital, Zhejiang University, School of Medicine (1) · Shahid Beheshti University of Medical Sciences (1) · Taipei Medical University WanFang Hospital (1) · The Fourth Affiliated Hospital of Zhejiang University School of Medicine (1)
Egypt (6) · United States (5) · China (2) · Bangladesh (1) · Iran (1) · Netherlands (1) · Puerto Rico (1) · Taiwan (1) · Turkey (Türkiye) (1) · Zambia (1)
Gailen D Marshall, Jr., MD, PhD (3) · Atoosa Saidpour (1) · Gailen D Marshall Jr., MD, PhD (1) · Gailen D. Marshall, Jr., MD, PhD (1) · Jing Lu, PhD (1) · Jogchum Plat, Professor (1) · Kazuya Masuda, PhD (1) · Magda M Ibrahim, M.B.B.ch (1) · Ming Shun Wu (1) · Mir Misbahuddin, MBBS, PhD (1) · Mohamed R El-Shanshory, MD (1) · Osama AR Tolba, MD (1) · Pawel Bogdanski, MD, PhD (1) · Rasha M Gamal, MD (1) · Ronald Mensink, Professor (1)
PMID 12639401, PMID 18039384, PMID 18714150, PMID 20016733, PMID 25331487, PMID 26813468, PMID 37975597
U19AT010838 (2), U54GM115428 (1)