19 recruiting, 15 completed, 5 active not recruiting, 4 not yet recruiting. 18 Phase 2, 17 Phase 1, 8 Not applicable, 4 Phase 3, 2 Phase 4.
Follow SPECT: new trials by email Literature Review of SPECT trials Research Report on SPECT
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Testing the Combination of Anti-cancer Drugs Actimab-A and Cemiplimab (REGN2810) to Improve Outcomes for Patients With Recurrent Glioblastoma Actinium Ac 225 Lintuzumab, Biospecimen Collection, Cemiplimab - Recurrent Glioblastoma, IDH-Wildtype, Recurrent Gliosarcoma | Phase 1 | Not yet recruiting | National Cancer Institute (NCI) | 30 | 2026-12-04 | 2026-06-12 |
| Escalating Cycle 1 Dose of Lu-177-PSMA-617 for the Treatment of Metastatic Castration Resistant Prostate Cancer Biospecimen Collection, Computed Tomography, Gallium Ga 68 Gozetotide - Metastatic Castration-Resistant Prostate Carcinoma, Stage IVB Prostate Cancer AJCC v8 | Phase 1 | Not yet recruiting | University of Michigan Rogel Cancer Center | 20 | 2026-12-01 | 2026-10-15 |
| Pluvicto for the Treatment of African American Men With Metastatic Castration-Resistant Prostate Cancer Biopsy Procedure, Biospecimen Collection, Bone Scan - Metastatic Castration-Resistant Prostate Adenocarcinoma, Stage IVB Prostate Cancer AJCC v8 | Phase 2 | Not yet recruiting | Emory University | 88 | 2026-11-02 | 2026-10-06 |
| Testing the Safety of the Anti-cancer Drug, Sn-117m-DTPA, for Advanced Cancers That Have Spread to Bones Biospecimen Collection, Bone Scan, Computed Tomography - Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma | Phase 1 | Withdrawn | National Cancer Institute (NCI) | 2026-10-01 | 2026-08-28 | |
| Testing an Anti-cancer Radio-Active Immunotherapy Called Lintuzumab Ac225 in Patients With High-Risk Myelodysplastic Syndrome That Has Not Responded to Other Treatment Actinium Ac 225 Lintuzumab, Bone Marrow Aspiration, Buccal Swab - Refractory Myelodysplastic Syndrome | Phase 1 | Suspended | National Cancer Institute (NCI) | 18 | 2026-09-03 | 2026-09-09 |
| Study of PSMA-targeted Therapy and Androgen Receptor Suppression in Low-volume Metastatic ProstatE Cancer: SPARKLE Trial Abiraterone Acetate, Biospecimen Collection, Leuprolide Acetate - Recurrent Prostate Adenocarcinoma, Stage IVB Prostate Cancer AJCC v8 | Phase 2 | Recruiting | Mayo Clinic | 202 | 2026-08-04 | 2026-09-18 |
| Molecular Imaging of EpCam Expression in Breast Cancer Using [99mTc]Tc-DARPinEc1-G3C [99mTc]Tc-DARPinEc1-G3C - Primary Breast Cancer | Phase 1 | Enrolling by invitation | Tomsk National Research Medical Center of the Russian Academy of Sciences | 10 | 2026-06-22 | 2026-08-26 |
| Y-90 Radioembolization, Durvalumab, Tremelimumab, and Zanzalintinib for the Treatment of Unresectable and Locally-Advanced Hepatocellular Carcinoma Angiogram, Biopsy Procedure, Biospecimen Collection - Locally Advanced Hepatocellular Carcinoma, Stage III Hepatocellular Carcinoma AJCC v8 | Phase 2 | Not yet recruiting | OHSU Knight Cancer Institute | 40 | 2026-04-02 | 2026-04-06 |
| Evaluation of Targeted Radionuclide Therapy of Lu-177 PSMA in Patients With Compromised Renal and/or Bone Marrow Function Lu-177, SPECT - Lu-177 PSMA | Phase 4 | Recruiting | M.D. Anderson Cancer Center | 25 | 2026-03-30 | 2026-08-04 |
| Personalized Neck Radiation Therapy Directed by Sentinel Lymph Node Biopsy for the Treatment of Oral Cavity Squamous Cell Carcinoma, PRECEDENT Trial Biospecimen Collection, Carboplatin, Cisplatin - Oral Cavity Squamous Cell Carcinoma, Stage I Lip and Oral Cavity Cancer AJCC v8 | Phase 2 | Recruiting | University of Michigan Rogel Cancer Center | 50 | 2025-07-17 | 2026-07-31 |
| 225Ac-DOTA-Anti-CD38 Daratumumab Monoclonal Antibody With Fludarabine, Melphalan and Total Marrow and Lymphoid Irradiation as Conditioning Treatment for Donor Stem Cell Transplant in Patients With High-Risk Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia and Myelodysplastic Syndrome Actinium Ac 225-DOTA-Daratumumab, Biospecimen Collection, Bone Marrow Aspiration - Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia | Phase 1 | Recruiting | City of Hope Medical Center | 15 | 2025-07-01 | 2026-10-30 |
| Low PSMA SUV Boost (LPS-Boost): Intensified 177Lu-PSMA-617 Treatment for Patients With Metastatic Castrate-Resistant Prostate Cancer With Low PSMA Expressing Disease Biospecimen Collection, Bone Scan, Computed Tomography - Metastatic Castration-Resistant Prostate Carcinoma, Stage IVB Prostate Cancer AJCC v8 | Phase 2 | Recruiting | University of Washington | 51 | 2025-04-29 | 2026-07-07 |
| Yttrium-90 (Y90) Radioembolization for the Treatment of Early Stage Renal Cell Carcinoma, The RENEGADE Trial Angiogram, Biospecimen Collection, Computed Tomography - Stage I Renal Cell Cancer, Stage II Renal Cell Cancer | Phase 1 / Phase 2 | Recruiting | Jonsson Comprehensive Cancer Center | 25 | 2024-12-26 | 2026-08-21 |
| Vorinostat and 177Lu-PSMA-617 for the Treatment of PSMA-Low Metastatic Castration-Resistant Prostate Cancer Biopsy Procedure, Biospecimen Collection, Bone Scan - Castration-Resistant Prostate Carcinoma, Metastatic Prostate Adenocarcinoma | Phase 2 | Recruiting | Fred Hutchinson Cancer Center | 15 | 2024-09-18 | 2026-08-06 |
| Re-treatment With 177Lu-PSMA-617 for the Treatment of Metastatic Castration-Resistant Prostate Cancer, RE-LuPSMA Trial Biospecimen Collection, Computed Tomography, Gallium Ga 68 Gozetotide - Castration-Resistant Prostate Carcinoma, Stage IVB Prostate Cancer AJCC v8 | Phase 2 | Recruiting | Jonsson Comprehensive Cancer Center | 40 | 2024-08-01 | 2026-03-13 |
| Phase 2 Randomized Trial of Flexible Dosing Schedule of 177Lu-PSMA-617 for the Treatment of Metastatic Castration-Resistant Prostate Cancer (FLEX-MRT) Computed Tomography, Gallium Ga 68 Gozetotide, Lutetium Lu 177 Vipivotide Tetraxetan - Prostate Carcinoma, Stage IVB Prostate Cancer American Joint Committee on Cancer (AJCC) v8 | Phase 2 | Recruiting | Jonsson Comprehensive Cancer Center | 90 | 2024-08-01 | 2026-03-10 |
| Supraphysiological Androgen to Enhance Treatment Activity in Metastatic Castration-Resistant Prostate Cancer, SPECTRA Study Biopsy Procedure, Biospecimen Collection, Bone Scan - Castration-Resistant Prostate Carcinoma, Metastatic Prostate Adenocarcinoma | Phase 2 | Recruiting | University of Washington | 69 | 2024-05-21 | 2026-07-21 |
| Schedule De-Escalation of 177Lu-PSMA-617 for the Treatment of Metastatic Castrate Resistant Prostate Cancer Biospecimen Collection, Bone Scan, Clinical Observation - Castration-Resistant Prostate Carcinoma, Stage IVB Prostate Cancer AJCC v8 | Phase 2 | Suspended | Mayo Clinic | 236 | 2024-05-03 | 2026-08-20 |
| Testing Pump Chemotherapy in Addition to Standard of Care Chemotherapy Versus Standard of Care Chemotherapy Alone for Patients With Unresectable Colorectal Liver Metastases: The PUMP Trial Bevacizumab, Capecitabine, Cetuximab - Metastatic Colorectal Carcinoma, Metastatic Malignant Neoplasm in the Liver | Phase 3 | Recruiting | ECOG-ACRIN Cancer Research Group | 408 | 2024-04-10 | 2026-09-24 |
| Intravenous Vesicular Stomatitis Virus in Patients With Peripheral T-cell Lymphoma Biopsy, Biospecimen Collection, Bone Marrow Biopsy - Peripheral T Cell Lymphoma, Relapsed Peripheral T-Cell Lymphoma | Phase 1 | Recruiting | Mayo Clinic | 21 | 2024-01-05 | 2026-07-01 |
Showing 20 of 51. Sign in to see all of them.
Prostatic Neoplasms (11) · Breast Neoplasms (6) · Carcinoma, Hepatocellular (4) · Coronary Artery Disease (3) · Leukemia, Myeloid, Acute (3) · Lung Neoplasms (3) · Myelodysplastic Syndromes (3) · Angina Pectoris (2) · Carcinoma, Non-Small-Cell Lung (2) · Heart Failure (2) · Liver Neoplasms (2) · Lymphoma, Large-Cell, Anaplastic (2) · Lymphoma, T-Cell (2) · Mouth Neoplasms (2) · Mycosis Fungoides (2)
Mayo Clinic (8) · Tomsk National Research Medical Center of the Russian Academy of Sciences (6) · Jonsson Comprehensive Cancer Center (5) · National Cancer Institute (NCI) (5) · University of Washington (5) · M.D. Anderson Cancer Center (4) · Emory University (2) · Fred Hutchinson Cancer Center (2) · University of Michigan Rogel Cancer Center (2) · Carina Mari Aparici (1) · City of Hope Medical Center (1) · ECOG-ACRIN Cancer Research Group (1) · GE Healthcare (1) · Hospital Italiano de Buenos Aires (1) · NRG Oncology (1)
United States (39) · Russia (6) · Argentina (2) · Canada (2) · Brazil (1) · Denmark (1) · Finland (1) · France (1) · United Kingdom (1)
Armeen Mahvash (2) · Jeremie Calais, MD (2) · Jing Zeng (2) · Michael Schweizer (2) · Adel Kardosh (1) · Angela Castellanos Rodriguez, MD, MSc (1) · Brenda M. Sandmaier (1) · Brian Shuch (1) · Carina Mari Aparici, MD (1) · David Lubin, MD, PhD (1) · David M Schuster, MD, FACR (1) · Dusica Babovic-Vuksanovic, MD (1) · Eileen O'Meara, MD (1) · Guofan Xu, MD (1) · Jacob E Berchuck, MD (1)
PMID 35175355, PMID 27225018, PMID 27570866, PMID 29122932, PMID 29555835, PMID 29716756, PMID 30335787, PMID 31083725, PMID 31142507, PMID 31983321, PMID 32662758, PMID 33027064, PMID 33641042, PMID 34032468, PMID 34172602, PMID 34385343, PMID 36712398, PMID 36898933, PMID 37052562, PMID 37130657, PMID 37753640, PMID 38407630, PMID 38509622, PMID 38955554, PMID 38981590, PMID 39788470, PMID 40590244, PMID 40876952, PMID 40887988, PMID 41276366, PMID 41425785, PMID 41679923, PMID 41913985
P30CA016672 (2), P30CA138292 (2), P50CA186781 (2), R01CA262613 (2), P01CA078902 (1), P30CA015083 (1), P30CA015704 (1), P30CA033572 (1), P50CA097186 (1), R01CA204301 (1), R01CA289631 (1), R01HL157273 (1), R37CA286450 (1), U10CA180820 (1), U10CA180821 (1)