6 completed, 2 unknown, 1 not yet recruiting, 1 terminated. 4 Not applicable, 2 Phase 1, 1 Phase 2, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 4 | Completed 2, Unknown 2 |
| Phase 1 | 2 | Completed 2 |
| Phase 2 | 1 | Completed 1 |
| Phase 3 | 1 | Terminated 1 |
Follow this drug Literature Review of Serotonin trials Research Report on Serotonin
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Postoperative GI Dysfunction and Nutrition in Malnourished Cancer Surgery Patients Serotonin (e.g., serotonin adipinate), Standard Prokinetic Therapy (excluding serotonin) - Gastrointestinal Dysfunction, Malnutrition | Not yet recruiting | Arma Ltd. | 120 | 2026-10-01 | 2026-06-03 | |
| Optimization of Diagnosis and Treatment of Depression Based on Multidimensional Clinical Assessment Classification SSRIs/SNRIs (Selective Serotonin Reuptake Inhibitors/ Serotonin and Norepinephrine Reuptake Inhibitors), Treatment as Usual, SSRIs/SNRIs (Selective Serotonin Reuptake Inhibitors/ Serotonin and Norepinephrine Reuptake Inhibitors) Combined with Magnetic Stimulations - Major Depressive Disorder | Not applicable | Unknown | Shanghai Mental Health Center | 960 | 2020-10-01 | 2020-08-27 |
| Efficacy of Online CBT for GAD Compared to Pharmaceutical Interventions SSRIs/SNRIs (Selective Serotonin Reuptake Inhibitors/ Serotonin and Norepinephrine Reuptake Inhibitors), Electronic Cognitive Behavioural Therapy - Generalized Anxiety Disorder | Not applicable | Completed | Dr. Nazanin Alavi | 115 | 2020-04-29 | 2024-04-10 |
| A Study of Individualized Diagnosis and Treatment for Major Depressive Disorder With Atypical Features SSRIs/SNRIs (Selective Serotonin Reuptake Inhibitors/ Serotonin and Norepinephrine Reuptake Inhibitors), SSRIs/SNRIs+Mood Stabilizer, SSRIs/SNRIs+Quetiapine - Major Depressive Disorder | Not applicable | Unknown | Shanghai Mental Health Center | 780 | 2019-08-12 | 2019-12-23 |
| A Mechanistic Evaluation of the Interactions Between Thermoceptive and Pruriceptive Sensory Processing Lidocaine, Histamine, Cowhage - Itch, Thermal Stimulation | Not applicable | Completed | Aalborg University | 59 | 2018-07-01 | 2020-07-08 |
| Serotonin, Leptin and Adiponectin Level in Patients With Postpartum Depression: Controlled Study leptin, serotonin and adiponectin level, leptin,serotonin, adiponectin level - Postpartum Depression | Completed | Zeynep Kamil Maternity and Pediatric Research and Training Hospital | 400 | 2016-02-01 | 2022-03-15 | |
| Glycemic Control and Endothelial Function in Patients With Type 2 Diabetes serotonin - Type 2 Diabetes Mellitus | Completed | Karolinska Institutet | 16 | 2016-01-01 | 2020-02-21 | |
| TRC102 and Temozolomide for Relapsed Solid Tumors and Lymphomas TRC102, CT scan, Lomotil - Lymphomas, Solid Tumors | Phase 1 / Phase 2 | Completed | National Cancer Institute (NCI) | 93 | 2013-07-12 | 2024-05-08 |
| An Open Label Positron Emission Tomography Study in Healthy Male Subjects to Investigate Brain DAT and SERT Occupancy,Pharmacokinetics and Safety of Single Oral Doses of GSK1360707, Using 11C- PE2I and 11C-DASB as PET Ligands GSK1360707 is a potent re-uptake inhibitor of the neurotransmitters dopamine, norepinephrine and serotonin - Depressive Disorder | Phase 1 | Completed | GlaxoSmithKline | 12 | 2009-04-03 | 2017-06-27 |
| Effect of Oral 5-HTP Intake on Urinary 5-HIAA Excretion 5-Hydroxy-Tryptamine - Carcinoid Tumors, Neuroendocrine Tumors | Phase 3 | Terminated | University of Western Ontario, Canada | 8 | 2005-05-01 | 2018-04-13 |
Depressive Disorder, Major (2) · Abdominal Neoplasms (1) · Carcinoid Tumor (1) · Colonic Neoplasms (1) · Depression, Postpartum (1) · Depressive Disorder (1) · Diabetes Mellitus, Type 2 (1) · Emergence Delirium (1) · Generalized Anxiety Disorder (1) · Lymphoma (1) · Malnutrition (1) · Neuroendocrine Tumors (1) · Pelvic Neoplasms (1) · Pruritus (1)
Shanghai Mental Health Center (2) · Aalborg University (1) · Arma Ltd. (1) · Dr. Nazanin Alavi (1) · GlaxoSmithKline (1) · Karolinska Institutet (1) · National Cancer Institute (NCI) (1) · University of Western Ontario, Canada (1) · Zeynep Kamil Maternity and Pediatric Research and Training Hospital (1)
Canada (2) · China (2) · Denmark (1) · Russia (1) · Sweden (1) · Turkey (Türkiye) (1) · United Kingdom (1) · United States (1)
Alice P Chen, M.D. (1) · Daihui Peng, MD. PhD. (1) · Daniele Riccio, MSc (1) · Nazanin Alavi (1) · Stan HM Van Uum, MD, PhD (1)
PMID 19427131, PMID 23685546, PMID 25469244, PMID 26748249, PMID 33857917, PMID 37143128