11 completed, 2 terminated, 2 unknown, 1 active not recruiting. 5 Phase 4, 4 Phase 3, 3 Phase 2, 2 Phase 1, 1 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 5 | Completed 4, Unknown 1 |
| Phase 3 | 4 | Completed 3, Terminated 1 |
| Phase 2 | 3 | Completed 2, Active not recruiting 1 |
| Phase 1 | 2 | Active not recruiting 1, Completed 1 |
| Not applicable | 1 | Completed 1 |
Follow Rotavirus vaccine: new trials by email Literature Review of Rotavirus vaccine trials Research Report on Rotavirus vaccine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Safety and Immunogenicity of an Investigational Pentavalent Meningococcal ABCYW Vaccine Against Meningococcal Disease in Children, Toddlers, and Infants Pentavalent Meningococcal ABCYW vaccine, MenACYW conjugate vaccine, Meningococcal group B vaccine - Meningococcal Immunization, Healthy Volunteers | Phase 1 / Phase 2 | Active not recruiting | Sanofi Pasteur, a Sanofi Company | 750 | 2024-11-05 | 2026-01-20 |
| Co-administration Study of an Investigational Live-Attenuated Respiratory Syncytial Virus Vaccine in Infants and Toddlers RSVt vaccine, Diphtheria, tetanus, pertussis, poliomyelitis , Haemophilus influenzae type b, and hepatitis B vaccine, Diphtheria, tetanus, pertussis, Haemophilus influenzae type b and poliomyelitis vaccine - RSV Immunization | Phase 3 | Terminated | Sanofi Pasteur, a Sanofi Company | 2226 | 2024-05-13 | 2026-10-05 |
| Study of a Quadrivalent Meningococcal Conjugate Vaccine (MenACYW Conjugate Vaccine) Given With Routine Pediatric Vaccines in Healthy Infants and Toddlers in India and the Republic of South Africa Meningococcal Polysaccharide (Serogroups A, C, Y, and W) Tetanus Toxoid Conjugate Vaccine, Meningococcal (Groups A, C, Y and W 135) Polysaccharide Diphtheria Toxoid Conjugate Vaccine, Oral bivalent types 1 and 3; Poliomyelitis Vaccine (OPV) - Meningococcal Immunisation, Healthy Volunteers | Phase 3 | Completed | Sanofi Pasteur, a Sanofi Company | 1528 | 2023-03-27 | 2026-01-21 |
| A Surveillance Study on Timing and Coverage Of Rotavirus and MenB Vaccine Co-administration in Campania Region, Italy Rotavirus Vaccine - Vaccination, Rotavirus Infections | Unknown | Federico II University | 2000 | 2022-05-01 | 2022-03-17 | |
| Development of a Live Attenuated Rotavirus Vaccine as a Human Infection Challenge Model Rotavirus vaccine - Diarrhoeal Disease | Not applicable | Completed | Centre for Infectious Disease Research in Zambia | 22 | 2019-01-22 | 2019-10-14 |
| Safety of a Quadrivalent Meningococcal Conjugate Vaccine Administered Concomitantly With Routine Pediatric Vaccines in Healthy Infants and Toddlers Meningococcal polysaccharide (serogroups A,C,Y and W) tetanus toxoid Conjugate vaccine (MenACYW Conjugate vaccine), Meningococcal (Groups A, C, Y and W 135) Oligosaccharide Diphtheria CRM197 Conjugate Vaccine (MENVEO®), Diphtheria, Tetanus, Acellular Pertussis, Poliovirus and Haemophilus b Vaccine - Healthy Volunteers (Meningococcal Infection) | Phase 3 | Completed | Sanofi Pasteur, a Sanofi Company | 2797 | 2018-09-17 | 2023-12-14 |
| Potential Mechanisms for Intussusception After Rotavirus Vaccine-Pilot Study Rotarix®,, Rotarix®, with other routine vaccines, RotaTeq®, - Intussusception, Rotavirus Infections | Phase 4 | Completed | Children's Hospital Medical Center, Cincinnati | 144 | 2015-11-01 | 2018-07-12 |
| Baby Vaccine Study (Sched3) DTaP/IPV/Hib vaccine, 13 valent Pneumococcal Conjugate Vaccine, Rotavirus vaccine - Infectious Diseases | Phase 2 | Completed | University of Oxford | 189 | 2015-08-01 | 2021-09-20 |
| The Safety and Immunogenicity Study of Rotavirus Vaccine Simultaneously Vaccinated With MR or MMR Vaccine rotavirus vaccine, measles-rubella vaccine, measles-mumps-rubella vaccine - Rotavirus | Phase 4 | Unknown | Sichuan Center for Disease Control and Prevention | 2800 | 2013-12-01 | 2014-06-03 |
| Coadministration of Measles-rubella and Rotavirus Vaccines Rotarix vaccine, measles-rubella vaccine - Measles Antibody Seroconversion, Rubella Antibody Seroconversion | Phase 4 | Completed | PATH | 482 | 2013-01-01 | 2019-03-13 |
| Zinc and/or Probiotic Supplementation of Rotavirus and Oral Polio Virus Vaccines Probiotic, Zinc, Probiotic placebo - Immunity to Oral Rotavirus Vaccine, Immunity to Oral Polio Vaccine | Phase 4 | Completed | PATH | 620 | 2012-07-01 | 2018-12-26 |
| Safety, Tolerability, and Immunogenicity of V419 in Healthy Infants When Given at 2, 4, and 11 to 12 Months (V419-008) PR5I, Rotavirus vaccine, Prevenar 13™ - Bacterial Infections, Virus Diseases | Phase 3 | Completed | MCM Vaccines B.V. | 1315 | 2011-11-23 | 2019-04-02 |
| Immunogenicity of Rotavirus Vaccine Rotavirus vaccine - Rotavirus Gastroenteritis | Phase 4 | Completed | PATH | 1140 | 2011-04-01 | 2013-08-30 |
| Gastroenteritis From Rotavirus Infection in Brazilian Children Less Than 5 Years of Age (Study V260-031). Rotavirus Vaccine - Pediatric Gastroenteritis | Terminated | Merck Sharp & Dohme LLC | 230 | 2010-08-01 | 2015-03-12 | |
| A Study of a Quadrivalent Meningococcal Tetanus Protein Conjugate Vaccine in Infants and Toddlers Quadrivalent Meningococcal Polysaccharide (A, C, Y, and W-135) Tetanus Protein Conjugate, Diphtheria and Tetanus Toxoids and Acellular Pertussis Adsorbed, Inactivated Poliovirus and Haemophilus B Conjugate (Tetanus Toxoid Conjugate) Vaccine Combined (DTaP-IPV/Hib combined), M-M-RII-Measles, Mumps, and Rubella Virus Vaccine Live - Meningitis, Meningococcal Infection | Phase 2 | Completed | Sanofi Pasteur, a Sanofi Company | 580 | 2009-12-16 | 2022-03-28 |
| Rotavirus Vaccine Produced by Butantan Institute rotavirus vaccine, placebo - Rotavirus Infections | Phase 1 | Completed | Butantan Institute | 80 | 2009-03-01 | 2013-04-25 |
Rotavirus Infections (4) · Meningococcal Infections (3) · Poliomyelitis (2) · Bacterial Infections (1) · Breast Feeding (1) · Communicable Diseases (1) · Diphtheria (1) · Haemophilus Infections (1) · Hepatitis B (1) · Intussusception (1) · Meningitis (1) · Tetanus (1) · Virus Diseases (1) · Whooping Cough (1)
Sanofi Pasteur, a Sanofi Company (5) · PATH (3) · Butantan Institute (1) · Centre for Infectious Disease Research in Zambia (1) · Children's Hospital Medical Center, Cincinnati (1) · Federico II University (1) · MCM Vaccines B.V. (1) · Merck Sharp & Dohme LLC (1) · Sichuan Center for Disease Control and Prevention (1) · University of Oxford (1)
United States (4) · Brazil (2) · India (2) · Puerto Rico (2) · United Kingdom (2) · Bangladesh (1) · Czechia (1) · Denmark (1) · Finland (1) · Germany (1) · Honduras (1) · Mexico (1) · Pakistan (1) · Poland (1) · South Africa (1)
Alexander R Precioso, MD,PhD (1) · Alfredo Gilio, MD (1) · Andrea Lo Vecchio, MD, PhD (1) · Edson Moreira, MD, PhD (1) · Gagandeep Kang, MD, PhD (1) · K Zaman, PhD, MPH (1) · Karen Broder, MD (1) · Mary A. Staat, MD, MPH (1) · Matthew D Snape (1) · Paulo Carvalho, MD (1) · Roma Chilengi, MBCHB (1) · S. Asad Ali, MBBS (1)
PMID 26035743, PMID 26823338, PMID 27288217, PMID 33109390, PMID 33428870, PMID 35144847, PMID 42642862
2019 (1), 2023 (1)