11 recruiting, 3 active not recruiting, 3 terminated, 3 withdrawn. 23 Phase 1, 2 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 23 | Recruiting 11, Active not recruiting 3, Terminated 3, Withdrawn 3, Completed 2, Not yet recruiting 1 |
| Phase 2 | 2 | Recruiting 1, Terminated 1 |
Follow Resection: new trials by email Literature Review of Resection trials Research Report on Resection
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| FPS-ZM1 With or Without Dexamethasone for Controlling Post Operative Cerebral Edema in Patients With Glioblastoma Biospecimen Collection, Computed Tomography, Dexamethasone - Glioblastoma, Malignant Glioma | Phase 1 | Not yet recruiting | City of Hope Medical Center | 24 | 2027-02-17 | 2026-08-27 |
| Locoregional Administration of Genetically Engineered Cells (EGFR/IL13Rα2 Pool-CAR T Cells) for the Treatment of Recurrent or Progressive High-Grade Gliomas Autologous Anti-EGFR/Anti-IL13Ralpha2 CAR T-cells, Biopsy Procedure, Biospecimen Collection - Recurrent Astrocytoma, IDH-Mutant, Grade 4, Recurrent Glioblastoma, IDH-Wildtype | Phase 1 | Recruiting | City of Hope Medical Center | 24 | 2026-05-26 | 2026-10-23 |
| An Optimized Ultrasound Twinkling Marker for the Imaging of Lymph Nodes in Patients With Clinically Node-Positive Breast Cancer, The UTMOST2 Trial Diagnostic Mammography, Resection, Ultrasound Imaging - Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage III Breast Cancer AJCC v8 | Phase 1 | Recruiting | Mayo Clinic | 20 | 2025-08-29 | 2026-09-23 |
| Intracranial Genetically Modified Immune Cells (TGFβR2KO/IL13Rα2 CAR T-Cells) for the Treatment of Recurrent or Progressive Glioblastoma or Grade 3 or 4 IDH-Mutant Astrocytoma Biospecimen Collection, Chimeric Antigen Receptor T-Cell Therapy, Echocardiography - Recurrent Astrocytoma, IDH-Mutant, Grade 3, Recurrent Astrocytoma, IDH-Mutant, Grade 4 | Phase 1 | Recruiting | City of Hope Medical Center | 27 | 2025-06-17 | 2026-10-22 |
| Peptide-Pulsed Dendritic Cell Vaccination in Combination With Nivolumab and Ipilimumab for the Treatment of Recurrent and/or Progressive Diffuse Hemispheric Glioma, H3 G34-mutant Dendritic Cell Tumor Peptide Vaccine, Ipilimumab, Leukapheresis - Diffuse Hemispheric Glioma, H3 G34-Mutant | Phase 1 | Withdrawn | Jonsson Comprehensive Cancer Center | 2024-12-01 | 2025-02-24 | |
| Triapine in Combination With Temozolomide for the Treatment of Patients With Recurrent Glioblastoma Biospecimen Collection, Magnetic Resonance Imaging, Questionnaire Administration - Recurrent Glioblastoma, IDH-Wildtype, Recurrent WHO Grade 2 Glioma | Phase 1 | Recruiting | Northwestern University | 22 | 2024-07-23 | 2026-09-09 |
| Anti-EGFRvIII synNotch Receptor Induced Anti-EphA2/IL-13Ralpha2 CAR (E-SYNC) T Cells E-SYNC T Cells, Cyclophosphamide (non-investigational), Fludarabine (non-investigational) - EGFR Gene Mutation, Glioblastoma | Phase 1 | Recruiting | Hideho Okada, MD, PhD | 20 | 2024-04-30 | 2026-08-13 |
| Proton-Spatially Fractionated Radiotherapy and Standard Radiation Therapy for the Treatment of Newly Diagnosed Retroperitoneal Soft Tissue Sarcoma Biopsy, Biospecimen Collection, Computed Tomography - Retroperitoneal Sarcoma | Phase 1 / Phase 2 | Recruiting | Northwestern University | 28 | 2024-04-02 | 2026-07-07 |
| Neoadjuvant Radio-chemotherapy Safety Pilot Study in Patients With Glioblastoma hypofractionated stereotactic radiotherapy, Stereotactic biopsy, resection - Glioblastoma, Glioblastoma Multiforme | Phase 1 | Recruiting | Hospital San Carlos, Madrid | 12 | 2024-03-21 | 2024-05-16 |
| Trotabresib in Combination With Vinorelbine and Radiation Therapy for the Treatment of HER2+ Breast Cancer With Central Nervous System or Leptomeningeal Metastasis Biospecimen Collection, Computed Tomography, Magnetic Resonance Imaging - Breast Carcinoma, Metastatic Malignant Neoplasm in the Brain | Phase 1 | Withdrawn | Northwestern University | 2023-12-31 | 2024-04-01 | |
| Evaluating the Use of Dual Imaging Techniques for Detection of Disease in Patients With Head and Neck Cancer Panitumumab-IRDye800, Indium In 111 Panitumumab, Single Photon Emission Computed Tomography - Head and Neck Squamous Cell Carcinoma, Recurrent Head and Neck Squamous Cell Carcinoma | Phase 1 | Recruiting | Vanderbilt-Ingram Cancer Center | 40 | 2023-10-03 | 2025-10-03 |
| Multiple Intracerebral Doses of Neural Stem Cell-Based Virotherapy (NSC-CRAd-S-pk7) for the Treatment of Recurrent High-Grade Gliomas Neural Stem Cells-expressing CRAd-S-pk7, Resection - Currently Only Enrolling Glioblastoma Patients at First Recurrence | Phase 1 | Recruiting | City of Hope Medical Center | 36 | 2023-05-02 | 2026-09-09 |
| Phase I CB-NK-TGF-ßR2-/NR3C1- in rGBM Cord Blood-derived Expanded Allogeneic Natural Killer Cells, Resection - Recurrent Gliosarcoma, Recurrent Supratentorial Glioblastoma | Phase 1 | Recruiting | M.D. Anderson Cancer Center | 25 | 2023-04-28 | 2026-09-04 |
| Intralesional Influenza Vaccine for the Treatment of Stage I-IV Melanoma Ipilimumab, Nivolumab, Pembrolizumab - Clinical Stage I Cutaneous Melanoma AJCC v8, Clinical Stage IA Cutaneous Melanoma AJCC v8 | Phase 1 | Recruiting | Carlo Contreras | 36 | 2021-10-20 | 2026-07-13 |
| Testing the Combination of Two Immunotherapy Drugs (Magrolimab and Dinutuximab) in Patients With Relapsed or Refractory Neuroblastoma or Relapsed Osteosarcoma Biospecimen Collection, Bone Marrow Aspiration, Bone Marrow Biopsy - High Risk Neuroblastoma, Recurrent Neuroblastoma | Phase 1 | Terminated | National Cancer Institute (NCI) | 12 | 2021-08-31 | 2026-06-30 |
| ONC201 and Radiation Therapy Before Surgery for the Treatment of Recurrent Glioblastoma Akt/ERK Inhibitor ONC201, Radiation Therapy, Resection - Recurrent Glioblastoma, Recurrent Gliosarcoma | Phase 1 | Withdrawn | Jonsson Comprehensive Cancer Center | 2021-05-01 | 2021-05-12 | |
| Surgical Nivolumab And Ipilimumab For Recurrent GBM Nivolumab-Placebo, Nivolumab, Ipilimumab-Placebo - Glioblastoma, GBM | Phase 1 | Active not recruiting | Gilbert Youssef | 63 | 2021-02-01 | 2026-10-19 |
| Systemic and Local Levels of Lidocaine During Surgery for the Removal of Glioblastoma Biospecimen Collection, Lidocaine, Resection - Glioblastoma | Phase 1 | Completed | University of California, Davis | 12 | 2021-01-20 | 2026-03-10 |
| Phase I Trial of DNA-PK Inhibitor (PEPOSERTIB ) in Combination With Radiation and Adjuvant Temozolomide in Newly Diagnosed MGMT Unmethylated and Recurrent Glioblastoma Peposertib, Radiation Therapy, Resection - Glioblastoma, Gliosarcoma | Phase 1 | Active not recruiting | M.D. Anderson Cancer Center | 29 | 2020-09-20 | 2026-10-16 |
| The Impact of an Antibiotic (Cefazolin) Before Surgery on the Microbiome in Patients With Stage I-II Melanoma Cefazolin, Resection - Clinical Stage I Cutaneous Melanoma AJCC v8, Clinical Stage IA Cutaneous Melanoma AJCC v8 | Phase 1 | Active not recruiting | M.D. Anderson Cancer Center | 20 | 2020-09-08 | 2026-05-20 |
Showing 20 of 23. Sign in to see all of them.
Glioblastoma (12) · Astrocytoma (3) · Brain Neoplasms (3) · Gliosarcoma (3) · Glioma (2) · Breast Neoplasms (1) · Carcinoma, Non-Small-Cell Lung (1) · Colorectal Neoplasms (1) · Lymphoma, Follicular (1) · Melanoma (1) · Meningeal Carcinomatosis (1) · Neuroblastoma (1) · Oligodendroglioma (1) · Osteosarcoma (1) · Rectal Neoplasms (1)
City of Hope Medical Center (4) · M.D. Anderson Cancer Center (3) · Northwestern University (3) · Jonsson Comprehensive Cancer Center (2) · Andrew B Lassman, MD (1) · Carlo Contreras (1) · Gilbert Youssef (1) · Hideho Okada, MD, PhD (1) · Hospital San Carlos, Madrid (1) · Mayo Clinic (1) · National Cancer Institute (NCI) (1) · The Netherlands Cancer Institute (1) · UNC Lineberger Comprehensive Cancer Center (1) · University of California, Davis (1) · Vanderbilt-Ingram Cancer Center (1)
United States (21) · Canada (1) · Netherlands (1) · Spain (1)
Behnam Badie (2) · Andrew B. Lassman, MD (1) · Andrew Wang, MD (1) · Anthony C Wang (1) · Carlo M Contreras, MD (1) · Christine U. Lee, MD, PhD (1) · Eben Rosenthal, MD (1) · Emily Z Keung (1) · Gilbert Youssef, MD (1) · Jana L Portnow (1) · Jana L Portnow, MD (1) · Jennifer Clarke, MD, MPH (1) · Karan Dixit, MD (1) · Kiarash Shahlaie (1) · Nazanin Majd, MD (1)
PMID 27784746, PMID 30858085, PMID 41177142, PMID 41498537
P30CA033572 (4), P30CA060553 (3), P30CA015704 (1), P30CA093373 (1), P50CA211015 (1), R01CA266233 (1), R01EB033008 (1), U01CA154967 (1), U19CA264338 (1), U19CA264512 (1), UM1CA228823 (1)