11 completed, 2 recruiting, 1 active not recruiting, 1 terminated. 16 Phase 3, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 16 | Completed 11, Recruiting 2, Active not recruiting 1, Terminated 1, Unknown 1 |
| Phase 2 | 1 | Active not recruiting 1 |
Follow remimazolam: new trials by email Literature Review of remimazolam trials Research Report on remimazolam
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Sedation During Endoscopy Using Remimazolam: Efficacy in a Novel Exploration Remimazolam, Propofol - Anesthesia, Sedation | Phase 3 | Completed | Massachusetts General Hospital | 100 | 2026-03-03 | 2026-09-14 |
| The Effects of Remimazolam on Cerebral Blood Flow Following General Anesthesia Induction Remimazolam, Propofol (Group P) - Cerebral Blood Flow | Phase 3 | Completed | Jun Zhang | 52 | 2025-12-29 | 2026-04-15 |
| Remimazolam vs. Midazolam for Sedation and Cognitive Outcomes in Orthopedic Surgery Midazolam, REMIMAZOLAM BESYLATE 2.5 Mg in 1 mL INTRAVENOUS INJECTION, POWDER, LYOPHILIZED, for SOLUTION [BYFAVO] - Postoperative Cognitive Dysfunction, Orthopedic Procedures | Phase 3 | Recruiting | Romanian Society for Enteral and Parenteral Nutrition | 120 | 2025-10-01 | 2025-10-01 |
| Effect of Remimazolam Sedation on Outcomes of Mechanically Ventilated Patients in the ICU Remimazolam, propofol - Remimazolam Besylate, Mechanically Ventilated ICU Patients | Phase 3 | Recruiting | Southeast University, China | 80 | 2025-04-01 | 2026-05-19 |
| Comparison of General Anesthesia Hemodynamics Between R and P in Patients Undergoing Laparoscopic Hepatectomy propofol, Remimazolam - Hypotension During Surgery | Phase 3 | Completed | Sun Yat-sen University | 88 | 2024-06-20 | 2024-12-03 |
| COnventional Vs. Optimised PERiprocedural Analgosedation Vs. Total IntraVEnous Anaesthesia for Pulsed-Field Ablation (COOPERATIVE-PFA) Remimazolam, Propofol - Atrial Fibrillation | Phase 3 | Completed | Charles University, Czech Republic | 127 | 2023-10-25 | 2025-02-03 |
| Remimazolam Versus Midaszolam for Sedation in Diagnostic Upper Gastrointestinal Endoscopy Remimazolam, Midazolam - Healthy | Phase 3 | Completed | Samsung Medical Center | 132 | 2023-04-05 | 2025-11-18 |
| Changes in Autonomic Nervous Activity and Blood Pressure After Anesthesia Induction: Remimazolam Versus Propofol Anesthesia induction with propofol, Anesthesia induction with remimazolam - General Anesthetics | Phase 3 | Completed | Daegu Catholic University Medical Center | 78 | 2022-12-19 | 2023-10-03 |
| Remimazolam vs Midazolam Cognitive and Motor Recovery After Intravenous Conscious Sedation for Dental Extractions. Remimazolam, Midazolam - Tooth Extraction | Phase 3 | Unknown | Guy's and St Thomas' NHS Foundation Trust | 128 | 2022-03-09 | 2023-12-05 |
| Investigation of Remimazolam in Children Undergoing Sedation for Medical Procedures Remimazolam - Pediatric ALL | Phase 2 / Phase 3 | Active not recruiting | Acacia Pharma Ltd | 100 | 2021-11-15 | 2025-07-01 |
| Efficacy and Safety of Remimazolam (CNS7056) Compared to Propofol for Intravenous Anesthesia During Elective Surgery Remimazolam, Propofol - Anesthesia, Intravenous | Phase 3 | Completed | Paion UK Ltd. | 469 | 2018-07-24 | 2020-05-28 |
| Comparative Clinical Study of Efficacy and Safety of Remimazolam and Propofol in Patients Undergoing Elective Surgery Under General Anaesthesia Remimazolam, Propofol, Fentanyl - General Anaesthesia | Phase 3 | Completed | R-Pharm | 150 | 2017-08-22 | 2018-09-13 |
| Safety and Efficacy of Remimazolam in ASA III and IV Patients Undergoing Colonoscopy Remimazolam, Midazolam, Placebo - Colonoscopy | Phase 3 | Completed | Paion UK Ltd. | 79 | 2015-11-01 | 2020-09-30 |
| Study of the Efficacy and Safety of Remimazolam in General Anesthesia in Adults Undergoing Cardiac Surgery Propofol, Remimazolam - Anesthesia | Phase 3 | Terminated | Paion UK Ltd. | 25 | 2015-07-01 | 2023-08-30 |
| A Phase III Study of Remimazolam in Patients Undergoing Bronchoscopy Remimazolam, Placebo, Midazolam - Bronchoscopy | Phase 3 | Completed | Paion UK Ltd. | 446 | 2015-04-01 | 2020-03-18 |
| A Phase III Study of the Efficacy and Safety of Remimazolam Compared to Placebo and Midazolam in Colonoscopy Patients Remimazolam, Midazolam, Placebo - Colonoscopy | Phase 3 | Completed | Paion UK Ltd. | 461 | 2015-03-30 | 2020-10-20 |
Atrial Fibrillation (1) · Cognitive Dysfunction (1) · Hip Fractures (1) · Hypotension (1) · Postoperative Cognitive Complications (1) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (1) · Wounds and Injuries (1)
Paion UK Ltd. (5) · Acacia Pharma Ltd (1) · Charles University, Czech Republic (1) · Daegu Catholic University Medical Center (1) · Guy's and St Thomas' NHS Foundation Trust (1) · Jun Zhang (1) · Massachusetts General Hospital (1) · R-Pharm (1) · Romanian Society for Enteral and Parenteral Nutrition (1) · Samsung Medical Center (1) · Southeast University, China (1) · Sun Yat-sen University (1)
United States (5) · China (3) · Germany (2) · South Korea (2) · Czechia (1) · Denmark (1) · Romania (1) · Russia (1) · United Kingdom (1)
Ana Maria Dumitriu, MD, PhD (1) · Bryan Kerr (1) · Douglas K Rex, MD (1) · Douglas Rex, MD (1) · Gerard Silvestri, MD (1) · Jonghae Kim, M.D. (1) · Jun Zhang (1) · Liliana Mirea, Associate Professor, MD (1) · Mikhail Samsonov (1) · Oluwaseun Johnson-Akeju, MD (1) · Stefan Probst, MD (1) · Taejun Kim (1)
PMID 29723512, PMID 30292760, PMID 40287932, PMID 41284133, PMID 41965699