8 completed, 6 unknown, 1 recruiting, 1 terminated. 17 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 17 | Completed 8, Unknown 6, Recruiting 1, Terminated 1, Withdrawn 1 |
Follow Rapamycin: new trials by email Literature Review of Rapamycin trials Research Report on Rapamycin
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Sirolimus Monotherapy in the Treatment of Antiphospholipid Antibody Related Thrombocytopenia Sirolimus, Placebo - Antiphospholipid (aPL)-Positive, Thrombocytopaenia | Phase 4 | Recruiting | Peking University First Hospital | 84 | 2025-01-07 | 2026-06-30 |
| Percutaneous Administration of Sirolimus in the Treatment of Superficial Complicated Vascular Anomalies Percutaneous sirolimus, Oral sirolimus - Kaposiform Hemangioendothelioma, Tufted Angioma | Phase 4 | Unknown | Children's Hospital of Fudan University | 75 | 2021-10-22 | 2024-03-15 |
| Sirolimus in the Treatment for Infantile Hepatic Hemangioendothelioma(IEEH) Sirolimus Oral Product, propranolol - Hemangioendothelioma of Liver | Phase 4 | Unknown | Shanghai Children's Medical Center | 36 | 2020-07-01 | 2020-05-29 |
| Guided Discontinuation Versus Maintenance Treatment of Sirolimus in Pediatric Patients With Kaposiform Hemangioendothelioma Sirolimus - Kaposiform Hemangioendothelioma, Kasabach-Merritt Syndrome | Phase 4 | Completed | Children's Hospital of Fudan University | 30 | 2020-07-01 | 2023-09-26 |
| Safety and Efficacy of Low-dose Sirolimus to Kaposiform Hemangioendothelioma Sirolimus(0.8mg/m2), Sirolimus(0.7mg/m2) - Hemangioma, Kaposiform Hemangioendothelioma | Phase 4 | Completed | Children's Hospital of Fudan University | 92 | 2019-05-01 | 2023-01-30 |
| Efficacy of Rapamycin (Sirolimus) in the Treatment of Peutz-Jeghers Syndrome Rapamycin - Peutz-Jeghers Syndrome | Phase 4 | Unknown | Peking Union Medical College Hospital | 10 | 2018-09-16 | 2019-01-23 |
| Efficacy of Rapamycin (Sirolimus) in the Treatment of BRBNS, Hereditary or Sporadic Venous Malformation Rapamycin - Blue Rubber Bleb Nevus Syndrome, Venous Malformation | Phase 4 | Unknown | Peking Union Medical College Hospital | 20 | 2018-07-31 | 2018-12-19 |
| Efficacy and Safety of Rapamycin (Sirolimus) in the Treatment of Symptomatic Uterine Fibroids and Leiomyomatosis rapamycin - Uterine Fibroids | Phase 4 | Unknown | Peking Union Medical College Hospital | 25 | 2018-01-01 | 2018-04-18 |
| Impact of Sirolimus and Maraviroc on CCR5 Expression and the HIV-1 Reservoir in HIV-infected Kidney Transplant Recipients Sirolimus + Maraviroc - Hiv, Kidney Transplant | Phase 4 | Withdrawn | University of Maryland, Baltimore | 2017-05-01 | 2019-12-16 | |
| Sirolimus Associated With Tacrolimus at Low Doses in Elderly Kidney Transplant Patients sirolimus, tacrolimus, mycophenolate - Disorder Related to Renal Transplantation, Cytomegalovirus Infections | Phase 4 | Completed | Associação Médico Espírita de Botucatu | 48 | 2014-01-01 | 2016-02-17 |
| Study of Sirolimus Versus Mycophenolate Liver Transplant Recipients With Recurrent Hepatitis C Virus (HCV) Mycophenolate to sirolimus switch - Hepatitis C | Phase 4 | Completed | London Health Sciences Centre | 11 | 2010-06-01 | 2015-02-26 |
| An Open, Single Centre, Randomised, Parallel Group Study to Investigate Three Different Immunosuppressive Regimens Rapamycin, Everolimus, Prednisone - Comparative Study, Immunosuppressive Agents | Phase 4 | Completed | University Hospital, Basel, Switzerland | 63 | 2008-07-01 | 2010-08-17 |
| Study Evaluating Conversion From Tacrolimus to Sirolimus in Stable Kidney Transplant Recipients Receiving Myfortic sirolimus - Renal Transplantation | Phase 4 | Completed | California Pacific Medical Center Research Institute | 29 | 2007-05-01 | 2020-10-27 |
| A Trial of Two Steroid-Free Approaches Toward Mycophenolate Mofetil-Based Monotherapy Immunosuppression Tacrolimus (TAC), Sirolimus, Alemtuzumab - Kidney Transplant Failure and Rejection | Phase 4 | Terminated | Northwestern University | 40 | 2005-04-01 | 2015-10-26 |
| Pilot Study to Investigate a Steroid Free Immunosuppressive Regimen for Renal Transplant Recipients Rapamycin - Kidney Transplantation | Phase 4 | Completed | University Hospital, Basel, Switzerland | 100 | 2005-01-01 | 2010-06-30 |
| Mycophenolate Mofetil and Rapamycin as Secondary Intervention vs. Continuation of Calcineurin Inhibitors in Patients at Risk for Chronic Renal Allograft Failure Rapamycin - Kidney Transplant | Phase 4 | Completed | Vanderbilt University Medical Center | 20 | 2000-06-01 | 2017-06-21 |
| Renal Function Optimization With Mycophenolate Mofetil (MMF) Immunosuppressor Regimes (ALHAMBRA) Tacrolimus, Rapamycin - Kidney Diseases, Graft Rejection | Phase 4 | Unknown | Sociedad Andaluza de Trasplantes de Organos y Tejidos | 94 | 2007-05-15 |
Kaposiform Hemangioendothelioma (3) · Hereditary Sensory and Autonomic Neuropathies (2) · Kasabach-Merritt Syndrome (2) · Rejection, Psychology (2) · Acquired Immunodeficiency Syndrome (1) · Blue rubber bleb nevus syndrome (1) · Cytomegalovirus Infections (1) · Hemangioma (1) · Hepatitis C (1) · Kidney Diseases (1) · Leiomyoma (1) · Peutz-Jeghers Syndrome (1) · Thrombocytopenia (1) · Tufted angioma (1)
Children's Hospital of Fudan University (3) · Peking Union Medical College Hospital (3) · University Hospital, Basel, Switzerland (2) · Associação Médico Espírita de Botucatu (1) · California Pacific Medical Center Research Institute (1) · London Health Sciences Centre (1) · Northwestern University (1) · Peking University First Hospital (1) · Shanghai Children's Medical Center (1) · Sociedad Andaluza de Trasplantes de Organos y Tejidos (1) · University of Maryland, Baltimore (1) · Vanderbilt University Medical Center (1)
China (8) · United States (4) · Switzerland (2) · Canada (1) · Spain (1)
Kai Li, MD, PhD (2) · Anthony Langone, M.D. (1) · Jennifer S Husson, MD,MPH (1) · Jiaolin Zhou, MD (1) · Joseph R Leventhal, MD, PhD (1) · Juerg U Steiger, MD (1) · Juerg U Steiger, Professor (1) · Lan Zhu, MD (1) · Miguel A Gonzalez Molina, MD (1) · Natasha Chandok, MD, FRCPC (1) · Song Gu, Doctor (1) · V. Ram Peddi, MD (1) · Vivian McAlister, MB, FRCSC (1)