3 completed, 1 recruiting, 1 terminated. 3 Phase 2, 2 Phase 4, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 3 | Completed 1, Recruiting 1, Terminated 1 |
| Phase 4 | 2 | Completed 2 |
| Phase 3 | 1 | Recruiting 1 |
Follow Kasabach-Merritt Syndrome: new trials by email Literature Review of Kasabach-Merritt Syndrome trials Research Report on Kasabach-Merritt Syndrome
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Low- vs High-Dose Sirolimus With Prednisolone for KHE and KMP Sirolimus (RAPAMUNE) - Kaposiform Hemangioendothelioma (KHE), Kasabach Merritt Phenomenon | Phase 2 / Phase 3 | Recruiting | Yi Ji | 76 | 2026-06-16 | 2026-06-18 |
| Guided Discontinuation Versus Maintenance Treatment of Sirolimus in Pediatric Patients With Kaposiform Hemangioendothelioma Sirolimus - Kaposiform Hemangioendothelioma, Kasabach-Merritt Syndrome | Phase 4 | Completed | Children's Hospital of Fudan University | 30 | 2020-07-01 | 2023-09-26 |
| Safety and Efficacy of Low-dose Sirolimus to Kaposiform Hemangioendothelioma Sirolimus(0.8mg/m2), Sirolimus(0.7mg/m2) - Hemangioma, Kaposiform Hemangioendothelioma | Phase 4 | Completed | Children's Hospital of Fudan University | 92 | 2019-05-01 | 2023-01-30 |
| A Study to Compare Vincristine to Sirolimus for Treatment of High Risk Vascular Tumors Vincristine, Sirolimus - Kaposiform Hemangioendothelioma (KHE), Kasabach-Merritt Syndrome | Phase 2 | Terminated | Boston Children's Hospital | 4 | 2017-06-14 | 2023-09-21 |
| Sirolimus Versus Sirolimus Plus Prednisolone for Kaposiform Hemangioendothelioma Sirolimus, Prednisolone - Kaposiform Hemangioendothelioma, Kasabach Merritt Phenomenon | Phase 2 | Completed | West China Hospital | 30 | 2017-06-01 | 2022-04-21 |
Kaposiform Hemangioendothelioma (5) · Hemangioendothelioma (1) · Hemangioma (1) · Tufted angioma (1) · Vascular Malformations (1)
Blood Platelet Disorders (5) · Cytopenia (5) · Hematologic Diseases (5) · Hemic and Lymphatic Diseases (5) · Neoplasms (5) · Neoplasms by Histologic Type (5) · Neoplasms, Vascular Tissue (5) · Thrombocytopenia (5) · Hemangioma (4) · Cardiovascular Abnormalities (1) · Cardiovascular Diseases (1) · Congenital Abnormalities (1) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (1)
Sirolimus (5) · Prednisolone (1) · Vincristine (1)
Children's Hospital of Fudan University (2) · Boston Children's Hospital (1) · West China Hospital (1) · Yi Ji (1)
China (4) · United States (1)
Kai Li, MD, PhD (2) · Denise Adams, MD (1) · Jiangyuan Zhou, MD (1) · Yi Ji (1) · Yi Ji, MD, PhD (1)
PMID 35030255, PMID 22871490, PMID 28486787, PMID 31489702, PMID 32014025, PMID 33580918, PMID 34082006, PMID 34273457, PMID 3691614, PMID 3936944, PMID 39831682, PMID 40107509, PMID 41831614