19 completed, 1 terminated. 20 Phase 1, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 20 | Completed 19, Terminated 1 |
| Phase 2 | 1 | Completed 1 |
Follow Quinidine: new trials by email Literature Review of Quinidine trials Research Report on Quinidine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study to Investigate the Effect of Food on Balcinrenone/Dapagliflozin Pharmacokinetics in Fed and Fasted State and Pharmacokinetics of Balcinrenone When Dosed With a P-gp Inhibitor in Healthy Participants. balcinrenone/ dapagliflozin, quinidine - Healthy Participants | Phase 1 | Completed | AstraZeneca | 14 | 2025-05-20 | 2025-08-12 |
| A Study to Investigate the Pharmacokinetics of AZD2389 in Healthy Participants When Administered Alone and in Combination With Quinidine AZD2389, Quinidine - Advanced Chronic Liver Disease, Healthy Participants | Phase 1 | Completed | AstraZeneca | 16 | 2025-05-12 | 2025-07-25 |
| A Drug-Drug Interaction Study to Evaluate the Effects of Itraconazole, Carbamazepine, Quinidine and Fluconazole on the Pharmacokinetics and Safety of EDP-323. EDP-323, Itraconazole, carbamazepine - RSV Infection, Drug Drug Interaction (DDI) | Phase 1 | Completed | Enanta Pharmaceuticals, Inc | 48 | 2025-01-27 | 2025-07-01 |
| A Drug-Drug Interaction Study of Orforglipron (LY3502970) With Quinidine in Healthy Participants Orforglipron, Midazolam, Quinidine - Healthy | Phase 1 | Completed | Eli Lilly and Company | 27 | 2024-12-06 | 2026-05-26 |
| A Single and Multiple Ascending Doses, Relative Bioavailability, Food Effect, and Drug-Drug Interaction Study of NX-5948 in Healthy Volunteers NX-5948, Esomeprazole, Placebo - Healthy Volunteer | Phase 1 | Completed | Nurix Therapeutics, Inc. | 223 | 2024-11-30 | 2026-07-28 |
| A Study to Assess the Effect of Voriconazole and Quinidine on the Pharmacokinetics of a Single Dose of Repotrectinib in Healthy Participants Repotrectinib, Voriconazole, Quinidine - Healthy Volunteers | Phase 1 | Completed | Bristol-Myers Squibb | 32 | 2024-08-26 | 2025-08-22 |
| A Clinical Trial to Evaluate MK-4208/Embibatinib in Healthy Adult Participants (MK-4208-001/Embibatinib-1014) Embibatinib, Rabeprazole, Midazolam - Healthy | Phase 1 | Completed | Terns, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) | 196 | 2023-12-21 | 2026-10-22 |
| Drug-Drug Interaction Study Between EDP-235, Itraconazole, Carbamazepine and Quinidine in Healthy Subjects. EDP-235, Itraconazole, Carbamazepine - COVID-19 | Phase 1 | Completed | Enanta Pharmaceuticals, Inc | 36 | 2022-10-06 | 2023-04-27 |
| A Study of Imlunestrant (LY3484356) in Female Healthy Participants Imlunestrant, Repaglinide, Omeprazole - Healthy | Phase 1 | Completed | Eli Lilly and Company | 113 | 2022-07-07 | 2025-12-12 |
| Drug-Drug Interaction Study Between EDP-514, Itraconazole, Carbamazepine, and Quinidine in Healthy Subjects EDP-514, Itraconazole, Carbamazepin - Hepatitis B | Phase 1 | Completed | Enanta Pharmaceuticals, Inc | 72 | 2020-11-05 | 2021-08-16 |
| Impact of Nuedexta on Bulbar Physiology and Function in ALS dextromethorphan HBr and quinidine sulfate - Amyotrophic Lateral Sclerosis | Phase 1 / Phase 2 | Completed | University of Florida | 28 | 2019-07-25 | 2023-03-08 |
| Drug-Drug Interaction Study Between EDP-938, Itraconazole, Rifampin, and Quinidine in Healthy Subjects EDP-938, Itraconazole, Rifampin - RSV Infection | Phase 1 | Completed | Enanta Pharmaceuticals, Inc | 72 | 2018-11-29 | 2019-06-14 |
| Drug-drug Interaction Study Between EDP-305, Fluconazole and Quinidine in Healthy Volunteers Fluconazole, Quinidine, EDP-305 - NASH - Nonalcoholic Steatohepatitis | Phase 1 | Completed | Enanta Pharmaceuticals, Inc | 48 | 2018-07-19 | 2018-12-05 |
| Study to Assess the Bioavailability, Pharmacokinetics, Safety, and Tolerability of AVP-923 in Healthy Adult Participants AVP-923 - Healthy Adult Male and Female Volunteers | Phase 1 | Completed | Avanir Pharmaceuticals | 17 | 2017-11-28 | 2018-02-23 |
| Study of the Electrocardiographic Effects of Ranolazine, Dofetilide, Verapamil, and Quinidine in Healthy Subjects Ranolazine, Dofetilide, Verapamil - Drug-induced Surface ECG Changes | Phase 1 | Completed | Food and Drug Administration (FDA) | 22 | 2013-05-01 | 2018-03-08 |
| Effect of P-glycoprotein Inhibition on Lenalidomide Pharmacokinetics in Healthy Males Lenalidomide, Quinidine, Temsirolimus - Healthy | Phase 1 | Completed | Celgene | 31 | 2012-10-01 | 2019-11-08 |
| Study in Healthy Volunteers to Investigate the Effects of Quinidine on the Pharmacokinetics of NKTR-118 Nektar 118, Quinidine, Quinidine placebo - Drug Induced Constipation | Phase 1 | Completed | AstraZeneca | 214 | 2012-03-01 | 2014-10-15 |
| A Study to Evaluate the Effect of Genotype on LY2216684 LY2216684, Quinidine - Depressive Disorder, Major | Phase 1 | Completed | Eli Lilly and Company | 18 | 2011-10-01 | 2018-10-26 |
| Safety and Pharmacokinetics of Quinidine Alone and in Combination With Dabigatran Etexilate dabigatran etexilate, quinidine - Healthy | Phase 1 | Completed | Boehringer Ingelheim | 42 | 2009-03-01 | 2014-06-24 |
| Relative Bioavailability of Dabigatran Etexilate Capsules With and Without Quinidine Sulfate Tablets and to Measure the Effect of Quinidine on the Absorption of Fexofenadine in Healthy Male and Female Volunteers Dabigatran etexilate capsules, Quinidine sulfate tablets, Fexofenadine tablets - Healthy | Phase 1 | Terminated | Boehringer Ingelheim | 42 | 2007-11-01 | 2014-06-24 |
Respiratory Syncytial Virus Infections (2) · Amyotrophic Lateral Sclerosis (1) · COVID-19 (1) · Depressive Disorder, Major (1) · Fasting (1) · Hepatitis B (1) · Lecithin Cholesterol Acyltransferase Deficiency (1) · Liver Cirrhosis (1) · Non-alcoholic Fatty Liver Disease (1)
Enanta Pharmaceuticals, Inc (5) · AstraZeneca (3) · Eli Lilly and Company (3) · Boehringer Ingelheim (2) · Avanir Pharmaceuticals (1) · Bristol-Myers Squibb (1) · Celgene (1) · Food and Drug Administration (FDA) (1) · Nurix Therapeutics, Inc. (1) · Terns, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) (1) · University of Florida (1)
United States (16) · United Kingdom (1)
Bo Fransson, MD (1) · Carlos Sanabria, MD (1) · Edward O'Mara, MD (1) · Emily Plowman, PhD (1) · Lauren Tabor, PhD (1) · Mark Sostek, MD (1) · Phil Leese, MD (1)
PMID 25054430, PMID 25870186, PMID 26324176, PMID 28036330, PMID 28036334, PMID 28213480