9 completed, 1 active not recruiting, 1 not yet recruiting, 1 terminated. 6 Not applicable, 3 Phase 3, 2 Phase 4, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 6 | Completed 4, Not yet recruiting 1, Terminated 1 |
| Phase 3 | 3 | Completed 3 |
| Phase 4 | 2 | Completed 2 |
| Phase 2 | 1 | Active not recruiting 1 |
Follow Placebo Lozenge: new trials by email Literature Review of Placebo Lozenge trials Research Report on Placebo Lozenge
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Probiotic Response in Periodontal Disease Probiotic Blend Lozenge, Placebo Lozenge - Periodontal Disease | Not applicable | Not yet recruiting | University of New Hampshire | 100 | 2026-10-01 | 2026-07-21 |
| Efficacy of SALI-10 Oral Probiotics in Experimental Gingivitis SALI-10 lozenge, Placebo lozenge - Gingivitis | Phase 2 | Active not recruiting | Ostia Sciences | 60 | 2025-09-01 | 2026-10-16 |
| Effect of Enzymes on Dental Biofilm Accumulation Enzyme-containing lozenge, Placebo lozenge - Dental Plaque | Not applicable | Completed | Novozymes A/S | 28 | 2022-09-19 | 2023-04-12 |
| The Oral Microbiome in OSCC ProDentis Lozenge, Placebo Lozenge - Oral Cancer | Not applicable | Completed | University of Iowa | 20 | 2022-04-20 | 2023-11-18 |
| Effect of Enzymes on Dental Biofilm Accumulation in Healthy Individuals Enzyme lozenge 1, Enzyme lozenge 2, Placebo lozenge - Dental Plaque | Not applicable | Terminated | Novozymes A/S | 80 | 2021-09-15 | 2022-06-09 |
| Effect of an Enzyme-containing Lozenge on Dental Biofilm in Healthy Individuals. Enzyme containing lozenge, Placebo lozenge - Dental Plaque, Gingivitis | Not applicable | Completed | Novozymes A/S | 24 | 2021-01-08 | 2021-10-07 |
| A Study to Determine the Efficacy and Safety of a Benzocaine Lozenge for Treatment of Sore Throat. Benzocaine 8 mg, Placebo - Sore Throat | Phase 3 | Completed | McNeil AB | 260 | 2018-02-02 | 2018-10-18 |
| Safety and Efficacy of a Sore Throat Lozenge DORITHRICIN in Patients With Acute Pharyngitis Benzalkonium Chloride-Benzocaine Topical, Placebo Oral Tablet - Pharyngitis | Phase 4 | Completed | Medice Arzneimittel Pütter GmbH & Co KG | 321 | 2017-02-01 | 2017-11-28 |
| Medicinal Nicotine for Preventing Cue Induced Craving Nicotine lozenge 4 mg, Placebo lozenge - Tobacco Use Disorder | Not applicable | Completed | University of Minnesota | 56 | 2013-09-01 | 2017-12-18 |
| Adjunct Immunotherapy With Immunoxel in Patients With TB and TB/HIV Immunoxel, Placebo - Tuberculosis, HIV | Phase 3 | Completed | Lisichansk Regional Tuberculosis Dispensary | 269 | 2010-01-01 | 2015-05-20 |
| Nicotine Lozenges for Treatment of Smokeless Tobacco Addiction Nicotine Lozenges, Placebo lozenge - Smokeless Tobacco Use | Phase 3 | Completed | Mayo Clinic | 270 | 2007-01-01 | 2013-04-24 |
| Pilot Study: Preoperative Nicotine Lozenges Nicotine Lozenge, Placebo Lozenge, Abstinence Advisement - Smoking | Phase 4 | Completed | Mayo Clinic | 46 | 2006-08-01 | 2014-12-22 |
Dental Plaque (3) · Gingivitis (3) · Pharyngitis (2) · Tobacco Use Disorder (2) · Communicable Diseases (1) · Deglutition Disorders (1) · Extensively Drug-Resistant Tuberculosis (1) · Mouth Neoplasms (1) · Periodontal Diseases (1) · Smoking (1) · Tobacco Use Cessation (1) · Tuberculosis (1) · Tuberculosis, Multidrug-Resistant (1)
Novozymes A/S (3) · Mayo Clinic (2) · Lisichansk Regional Tuberculosis Dispensary (1) · McNeil AB (1) · Medice Arzneimittel Pütter GmbH & Co KG (1) · Ostia Sciences (1) · University of Iowa (1) · University of Minnesota (1) · University of New Hampshire (1)
United States (5) · Denmark (2) · Canada (1) · Germany (1) · Mongolia (1) · Russia (1) · Ukraine (1)
Sebastian Schlafer, DDS, PhD (2) · David Drake, MS, PhD (1) · David O Warner, MD (1) · Dr. Michael Goldberg, MDM (1) · Jeffery L Milleman, DDS, MPA (1) · Jon O. Ebbert, M.D. (1) · Michael Kotlyar, PharmD (1) · R Ammer, MD, PhD (1) · Steven Sacavage (1)
PMID 22397570, PMID 22401633, PMID 27868466, PMID 30329199, PMID 40676928
2016 (1), R01CA121165 (1)